Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Anti-GABAB1 Receptor Antibody from AbboMax

Published: Thursday, December 19, 2013
Last Updated: Thursday, December 19, 2013
Bookmark and Share
Recent progress in neuroscience research from the Company.

Neurotransmitters are chemical messengers that transmit and modulate signals from neurons to other cells of the brain and body across a synapse. When a neurotransmitter binds to its corresponding receptor, it activates or inhibits the receptor's associated pathway.

GABA, the most prevalent inhibitory neurotransmitter in the mammalian central nervous system, plays an essential role in regulating vital neurological functions. GABA’s natural function is to reduce the activity of the neurons to which it binds through GABA receptors (GABARs).

Regulation of both excitatory and inhibitory synaptic transmission is critical for proper nervous system function. GABARs are promising drug targets for a wide spectrum of psychiatric and neurological disorders. They are involved in sedative and anxiolytic activities.

Enhancement of GABA signaling has been demonstrated in patients with central nervous system hypersomnias. GABA-ergic disturbances are hallmark features of schizophrenia and other neuropsychiatric disorders.

GABA-ergic system has been associated consistently with atypicalities in autism and aggressive behavior. Modulators of the GABARs may be useful in the treatment of visual, sleep, and cognitive disorders.

GABARs have been associated with seizures and memory dysfunction when disrupted. The up-regulations of GABA in the brain may lead to an antiepileptic effect. The cerebellar cortex, the brain region responsible for motor coordination and learning expresses a high density of GABARs.

Repeated alcohol exposure during the third trimester of pregnancy increases expression of GABARs in cerebellar granule neurons and delays motor development in rats. Ethanol significantly reduces the brain metabolism, probably via action at specific GABARs. These receptors an important role in the neuroprotective effects of anthocyanins against ethanol.

Interestingly, increased expression of GABARs has been detected in several human cancer cells and tissues.

It was demonstrated that the absence of functional GABARs disturbs glucose homeostasis in mice.

AbboMax offers new anti-GABAB1 receptor polyclonal antibody as well as an extensive collection of neuroscience related antibodies.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,400+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Worms Point Way Toward Viral Strategies
Rice University wins NIH grant to study how nematodes handle gastrointestinal viruses.
How The 'Police' Of The Cell World Deal With 'Intruders' And The 'Injured'
Findings may help discover new targets to manipulate inflammation.
Vitamin C May Boost Leukemia Treatment
Studies show that supplementing an epigenetic cancer drug with vitamin C enhanced the drug's effectiveness.
‘Lead Actors’ in Immune Cell Development
A new study, led by scientists at The Scripps Research Institute (TSRI), reveals a surprising twist in immune biology.
Microbiome Impacts Tissue Repair, Regeneration
Researchers at the Stowers Institute have established a definitive link between the makeup of the microbiome, the host immune response, and an organism’s ability to heal itself.
Pancreatic Cancer’s Aggression Explained
Internal conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer.
Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
Oxygen Can Impair Cancer Immunotherapy
Researchers have identified a mechanism within the lungs where anticancer immune resposnse is inhibited.
LncRNAs Maintain Immune Health
Long non-coding RNAs are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!