Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Commonly Used Drugs May Not Be Effective Against Autoimmune Illness

Published: Tuesday, March 18, 2014
Last Updated: Tuesday, March 18, 2014
Bookmark and Share
The study appears in the Cell Press journal Immunity.

Drugs for autoimmune diseases like lupus that block only one of the two principal signaling pathways can activate an overabundance of one potentially disease-causing type of immune cell population over another, a Yale study has found.

The findings about T lymphocytes, white blood cells that regulate the immune response, have implications for the development of new vaccination strategies and therapies for autoimmune diseases.

The researchers studied this process in a model of viral infection that is similar to human influenza and certain autoimmune diseases like systemic lupus erythematosus (SLE). They uncovered opposing roles for signaling pathways STAT3 and type I interferon (IFN) in differentiating the T helper cells that regulate immune cell response to viruses. Blockade of one resulted in an increase of T helper cells in the other that could lead to an immune system overreaction, and, ultimately, in lupus, exacerbation of the autoimmune disease.

Patients with autoimmune diseases like lupus contain both populations of T lymphocytes examined in this study. Previous strategies have been focused on treating patients by blocking one principal pathway or the other.

Based on findings in the Yale work, such a strategy could boomerang, promoting activation of the opposing pathway, and lack of therapeutic efficacy. By contrast, the work suggests that more effective therapies should block both pathways.

“This suggests that both pathways would have to be blocked in human SLE in order not to risk exacerbation of one or the other,” said senior author Dr. Joseph Craft, the Paul B. Beeson Professor of Rheumatology, professor of immunobiology, and director of the investigative medicine program at Yale School of Medicine.

Standard treatments for SLE and other autoimmune illnesses involve steroids and immunosuppressive drugs, as well as newer, cutting-edge biologics, but Craft says these are not as beneficial as the scientific community had hoped. “Our lab and others are working now on combining therapies to block pathways for both inflammation and antibody production,” he said.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Creating More Potent Vaccines
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity.
Wednesday, July 08, 2015
Researchers Solve Multiple Sclerosis Puzzle
Yale study shows the role that T cells play in MS.
Monday, May 18, 2015
New Tool To Explore Mysteries Of The Immune System
Yale scientists use CyTOF to study a range of conditions.
Monday, April 20, 2015
Cold Virus Replicates Better At Cooler Temperatures
Study shows that the immune response to rhinovirus is influenced by temperature.
Tuesday, January 06, 2015
New Class of Synthetic Molecules Mimics Antibodies
A Yale University lab has crafted the first synthetic molecules that have both the targeting and response functions of antibodies.
Wednesday, December 24, 2014
Protein Predicts Response To New Immunotherapy Drug
Trial shows that response to treatment may be predicted by the presence of an immune-suppressing protein in non-cancerous immune cells.
Friday, November 28, 2014
Immune System Surprise Hints at New Strategy for Fighting HIV
Surprising twist may open a new avenue in the fight.
Tuesday, November 18, 2014
Immune Cells get Cancer-Fighting Boost From Nanomaterials
Yale researchers used bundled carbon nanotubes to incubate cytotoxic T cells.
Monday, August 18, 2014
Yale Team Implants Human Innate Immune Cells in Mice
Groundbreaking study has reproduced human immune function at a level not seen previously.
Tuesday, March 18, 2014
Lung Disease and Melanoma: a Common Molecular Mechanism?
Researchers have solved a biological mystery about the common genesis of many serious diseases such as asthma and metastatic melanoma.
Monday, September 02, 2013
Drug Preserves Beta Cells in New Cases of Type 1 Diabetes
A drug in clinical trials has been shown to preserve insulin-producing pancreatic beta cells in nearly half of subjects newly diagnosed with type 1 diabetes.
Tuesday, August 06, 2013
Nature’s Own Nanoparticles Harnessed to Target Disease
Using a novel form of immune-genetic therapy, researchers have successfully inhibited a strong immune allergic inflammatory response in the skin of mice.
Friday, July 12, 2013
Promising Drug Prevents Cancer Cells from Shutting Down Immune System
An investigational drug that targets the immune system’s ability to fight cancer is showing promising results in Yale Cancer Center (YCC) patients.
Monday, June 10, 2013
Combined Immunotherapy Shows Promising Results Against Advanced Melanoma
Combining two cancer immunotherapy drugs in patients with advanced melanoma produced rates of tumor regression that appeared greater than in prior trials with either drug alone.
Monday, June 10, 2013
Combined Immunotherapy Shows Promising Results Against Advanced Melanoma
Tumor regression rates are produced by combining two cancer immunotherapy drugs.
Wednesday, June 05, 2013
Scientific News
Inciting an Immune Attack On Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Inflammation Linked to Colon Cancer Metastasis
A new Arizona State University research study led by Biodesign Institute executive director Raymond DuBois has identified for the first time the details of how inflammation triggers colon cancer cells to spread to other organs, or metastasize.
New Strategy for Combating Adenoviruses
Using an animal model they developed, Saint Louis University and Utah State university researchers have identified a strategy that could keep a common group of viruses called adenoviruses from replicating and causing sickness in humans.
Major Advance Toward More Effective, Long-Lasting Flu Vaccine
Collaboration shows vaccine candidate can produce powerful ‘broadly neutralizing antibodies’ in animal models.
Immune System: Help for Killer Cells
A study from the University of Bonn may show the way to more effective vaccines.
Protein Found to Control Inflammatory Response
A new Northwestern Medicine study shows that a protein called POP1 prevents severe inflammation and, potentially, diseases caused by excessive inflammatory responses.
A Leap Forward in Vaccinating Against HIV
A team of scientists has developed an experimental vaccine candidate that successfully stimulates the immune system activity in animal models necessary to stop HIV infection.
MRI Scanners Can Steer Therapeutics to Specific Target Sites
Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.
Agricultural Intervention Improves HIV Outcomes
A multifaceted farming intervention can reduce food insecurity while improving HIV outcomes in patients in Kenya, according to a randomized, controlled trial led by researchers at UC San Francisco.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!