Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Immunovaccine's DepoVax™ Technology Underpins New Experimental Therapy for Cancers

Published: Wednesday, April 09, 2014
Last Updated: Wednesday, April 09, 2014
Bookmark and Share
IMV vaccine adjuvant technology of choice for Dana-Farber's HPV-related cancer clinical trial.

Immunovaccine Inc. has announced that its DepoVax™ adjuvanting technology will underlie the design of a new cancer vaccine trial that will be conducted by the Dana-Farber Cancer Institute to treat cervical and head and neck cancer.

In a competitive process, Dana-Farber has been awarded a research grant of $1.2 million for clinical evaluation of its cancer vaccine.

The grant from Stand Up To Cancer (SU2C) and the Farrah Fawcett Foundation was awarded to a team of Dana-Farber researchers in a ceremony last evening at the 2014 American Association for Cancer Research (AACR) annual meeting.

The three-year grant will be used to fund a Phase I clinical trial of the group's peptide cancer antigen formulated in DepoVax in patients with HPV-related cervical and head and neck cancers.

The grant was awarded based on a proposal highlighting the potential of Dana-Farber's proposed cancer antigen identified by a new mass spectrometry method termed Poisson detection MS and Immunovaccine's DepoVax platform.

The DepoVax data focused on clinical trial results with DPX-Survivac, which demonstrated strong immune response activity in cancer patients and the immune enhancement observed with the immune modulating agent cyclophosphamide.

Dana-Farber's proposed Phase I study in HPV-related cancers will use the same approach, formulating the Institute's peptide-based vaccine in DepoVax and administering it to patients in combination with cyclophosphamide.

"We believe that the grant committee was encouraged by novel interdisciplinary science in conjunction with the powerful immunogenicity data that Immunovaccine has collected to date with our DPX-Survivac cancer vaccine candidate," stated Marc Mansour, Ph.D., chief operating officer of Immunovaccine. "We are excited to work with the talented team at Dana-Farber and add value to their clinical program with our DepoVax technology. Our previous work with DPX-Survivac gives us confidence that DepoVax has the potential to induce strong immunological responses to their novel antigen to enable the vaccine in the clinic."

The SU2C-Farrah Fawcett Foundation HPV Translational Research Team Grant provides three years of funding for a multidisciplinary, translational cancer research project that addresses critical problems in HPV-related cancers and that can deliver near-term patient benefit through investigation by a team of two expert investigators.

To be considered for the grant, research project designs were required to include clear plans indicating how the work will be translated into the clinic and deliver near-term benefits to patients with HPV-related cancers. HPV infection causes virtually all cervical cancers, and many anal, vaginal, vulvar, penile, and oropharyngeal cancers.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Immunovaccine Signs Research Agreement with OncoTherapy Science
Immunovaccine Inc. announced that it has signed a collaborative research agreement with OncoTherapy Science Inc. to explore the efficacy of their novel peptide cancer antigen in Immunovaccine's DepoVax™ vaccine delivery and enhancement platform.
Tuesday, November 30, 2010
Scientific News
Gut Bacteria Older than Human Species
Some bacteria have lived in the human gut since before we were human, suggesting evolution could have a larger role inhuman bacterial makeup.
Evidence of Mosquito Transmitting Zika
A direct link between the Yellow fever mosquito and Zika transmission has been found following investigation into selective mosquito control.
Antibody-Based Drug for Multiple Sclerosis
New antibody-based drug paves the way for new strategies for controlling and treating multiple sclerosis.
Three-Drug Combinations Counter Antibiotic Resistance
Research shows that combinations of three different antibiotics can treat resistant bacteria, even if they are ineffective independently.
Mapping Zika’s Routes to Developing Fetus
UC researchers show how Zika virus travels from a pregnant woman to her fetus, and also identified a drug that could stop it.
Treating HIV with Cancer-Fighting Gene Shows Promise
A type of gene immunotherapy that has shown promising results against cancer could also be used against HIV.
Protein Teams Activate T-Cells
Caltech researchers have discovered T-cell genetic switching is controlled by four proteins acting in a multi-tiered fashion.
'Antigen-Presenting Cell' Defends Against Cancer
Through advanced imaging, researchers have identified cells that encourages increases in immune system cancer defences.
Zika Epidemic Likely to End Within Three Years
A team of scientists has predicted that the current Zika epidemic is likely to end within three years because there will be too few people left to infect.
Go-Between Immune Cell is Key to Priming the Body’s Fight Against Cancer
‘Antigen-presenting cell’ activates T cells by alerting them to the presence of tumors.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!