Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Key Genetic Link Between Chronic Pain Conditions Discovered

Published: Wednesday, May 21, 2014
Last Updated: Wednesday, May 21, 2014
Bookmark and Share
Research from at King’s College London suggests that some people may be genetically predisposed to suffer from conditions of this type.

The study, published in the journal Pain, examined identical and non-identical twins and established that IBS, musculoskeletal pain, pelvic pain and dry eye disease may have hereditary links. Migraine was shown, as previously, to have a degree of genetic susceptibility but was not genetically linked to the other conditions.

Chronic pain syndromes such as irritable bowel syndrome (IBS) and chronic pelvic pain can severely affect someone’s quality of life and their diagnosis relies on the presentation of symptoms, not on evidence of inflammation or other biomarkers on testing. These types of conditions are poorly defined and a challenge to healthcare providers because of their complex physiology, poor response to therapy and associated psychological elements. Chronic pain syndromes are more often reported in women than men.

The research team, funded by the Pain Research Foundation, studied more than 8,000 pairs of twins from the TwinsUK cohort using questionnaires asking about subjects’ chronic pain symptoms. The sample compared groups of identical twins (sharing 100 per cent of their DNA) and non-identical twins (sharing 50 per cent of their DNA), with the differences between these two groups providing important information about the heritability of the conditions.

All of the CPS studied were more likely to be found in both twins in a identical pair than in the non-identical group, leading to the conclusion that each of the five syndromes are heritable. There was also a higher prevalence of CPS in females than males as expected.

Further analysis of different combinations of these CPS in female twin pairs showed that there were also stronger links between the syndromes in the identical group than in the non-identical group, indicative of a genetic link between four of the conditions (migraine was excluded from this second analysis). This suggests a common genetic pathway for CPS in general which was estimated to be 66 per cent heritable. 

Dr Frances Williams, lead researcher from the Department of Twin Research at King’s College London said: ‘This study is one of the first to examine the role of genetic and environmental factors in explaining the links between different chronic pain syndromes. The findings have clearly suggested that CPS may be heritable within families. With further research, these findings could then lead to therapies which may change the lives of those suffering with chronic pain.’

The presence of a possible genetic predisposition to CPS is also supported by similarities in symptoms and could explain why many sufferers have more than one of these kinds of diseases. Shared symptoms such as fatigue, memory loss, sleep disturbance are often seen. Migraine was found less commonly with the other CPS so appears to be a different disease entity and was excluded from simultaneous analysis with the other syndromes.

Conditions such as these are often overlooked and not considered a research priority and so, as one of the first studies to examine the role of genetic and environmental factors in explaining possible links, these findings can now justify further study to find common genetic variants.

The overlap found between CPS found in this study is suggestive of an underlying genetic pathway, common for all CPS and could lead to more effective, targeted therapies in the future. This has the potential to significantly increase the quality of life for sufferers of conditions with chronic pain. 


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Inflammation Linked to Colon Cancer Metastasis
A new Arizona State University research study led by Biodesign Institute executive director Raymond DuBois has identified for the first time the details of how inflammation triggers colon cancer cells to spread to other organs, or metastasize.
New Strategy for Combating Adenoviruses
Using an animal model they developed, Saint Louis University and Utah State university researchers have identified a strategy that could keep a common group of viruses called adenoviruses from replicating and causing sickness in humans.
Major Advance Toward More Effective, Long-Lasting Flu Vaccine
Collaboration shows vaccine candidate can produce powerful ‘broadly neutralizing antibodies’ in animal models.
Immune System: Help for Killer Cells
A study from the University of Bonn may show the way to more effective vaccines.
Protein Found to Control Inflammatory Response
A new Northwestern Medicine study shows that a protein called POP1 prevents severe inflammation and, potentially, diseases caused by excessive inflammatory responses.
A Leap Forward in Vaccinating Against HIV
A team of scientists has developed an experimental vaccine candidate that successfully stimulates the immune system activity in animal models necessary to stop HIV infection.
MRI Scanners Can Steer Therapeutics to Specific Target Sites
Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.
Agricultural Intervention Improves HIV Outcomes
A multifaceted farming intervention can reduce food insecurity while improving HIV outcomes in patients in Kenya, according to a randomized, controlled trial led by researchers at UC San Francisco.
Team Finds Early Inflammatory Response Paralyzes T Cells
Findings could have enormous implications for immunotherapy, autoimmune disorders, transplants and other aspects of immunity.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!