Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Bowel Disease Gene Discovery

Published: Wednesday, August 27, 2014
Last Updated: Wednesday, August 27, 2014
Bookmark and Share
Genetic changes that occur in patients with the bowel condition Crohn’s disease could hold clues to fighting the illness.

Scientists have identified chemical changes in the DNA of patients with Crohn’s disease that could help to screen people for the disease.

Blood test

These changes can be detected in blood samples, opening the door to a simple test for Crohn’s disease.

The findings also offer clues to how the condition develops and reveal possible targets for new treatments.

Environmental triggers

Several genes have been linked to Crohn’s disease but not everybody who inherits these genes will develop the condition. The discovery sheds light on how environmental factors that vary between individuals - such as diet and gut bacteria - can trigger Crohn’s disease in some people who have inherited these genes.

'Our study gives the strongest evidence yet that epigenetic changes are involved in Crohn’s disease. The findings provide a potential mechanism whereby diet or other environmental factors may modify genetic material to cause Crohn’s disease. We hope the findings will help to identify much-needed treatment opportunities for this debilitating condition.'

Professor Jack Satsangi
Head of Gastroenterology Unit, Centre for Genomic and Experimental Medicine

Chemical changes

A study involving children with Crohn’s disease in Edinburgh, Aberdeen, and Glasgow - led by the University of Edinburgh - identified chemical changes in their DNA that affect how their genes work.
The genes that are affected by these changes could represent useful targets for new treatments, the scientists say.

Disease monitoring

A DNA test alone would not be enough to diagnose the disease but it could pinpoint those at most risk and help to reduce the number of people who are put forward for further tests, researchers say.
It could also help to monitor progression of the disease and how patients respond to treatment.

Crohn’s disease

Crohn’s disease is a type of inflammatory bowel disease and a common cause of chronic ill-health in the UK. It is a particular problem in children in Scotland, where the incidence of the disease has increased by 500 per cent in the past 50 years.

At present there is no way to prevent Crohn’s disease and therapy is focused on treating the symptoms, which may include abdominal pain, diarrhoea and severe weight loss.
The study is published in the journal Inflammatory Bowel Diseases.



Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Neural Networks Adapt to the Presence of a Toxic HIV Protein
HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIV infected patients.
HIV Protein Manipulates Hundreds of Human Genes
Findings search for new or improved treatments for patients with AIDS.
Breaking the Brain’s Garbage Disposal
The children’s ataxia gene problem turned out to be not such a big deal genetically — it was such a slight mutation that it barely changed the way the cells made the protein.
Flesh-Eating Bacteria Work Together
Scientists recently discovered different strains of deadly flesh-eating bacteria working together to spread infection and they now have a better understanding of the role of the toxins they produce. The discovery could change how the illness and other diseases are treated.
Utilizing Antibodies from Ebola Survivors
A collaborative team from The University of Texas Medical Branch at Galveston, Vanderbilt University, The Scripps Research Institute and Integral Molecular Inc. have learned that antibodies in the blood of people who have survived a strain of the Ebola virus can kill various types of Ebola.
Antibiotic Use in Early Life Disrupts Gut Microbiota
The use of antibiotics in early childhood interferes with normal development of the intestinal microbiota, shows research conducted at the University of Helsinki.
Easier Diagnosis for Fungal Infection of the Lungs
A new clinical imaging method developed in collaboration with a University of Exeter academic may enable doctors to tackle one of the main killers of patients with weakened immune systems sooner and more effectively.
Mitochondrial Troublemakers Unmasked in Lupus
Drivers of autoimmune disease inflammation discovered in the traps of pathogen-capturing white blood cells.
Important Regulator of Immune System Decoded
Plasma cells play a key role in our immune system. Now scientists at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria, and at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, succeeded in characterizing a central regulator of plasma cell function.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!