Corporate Banner
Satellite Banner
Immunology
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Bowel Disease Gene Discovery

Published: Wednesday, August 27, 2014
Last Updated: Wednesday, August 27, 2014
Bookmark and Share
Genetic changes that occur in patients with the bowel condition Crohn’s disease could hold clues to fighting the illness.

Scientists have identified chemical changes in the DNA of patients with Crohn’s disease that could help to screen people for the disease.

Blood test

These changes can be detected in blood samples, opening the door to a simple test for Crohn’s disease.

The findings also offer clues to how the condition develops and reveal possible targets for new treatments.

Environmental triggers

Several genes have been linked to Crohn’s disease but not everybody who inherits these genes will develop the condition. The discovery sheds light on how environmental factors that vary between individuals - such as diet and gut bacteria - can trigger Crohn’s disease in some people who have inherited these genes.

'Our study gives the strongest evidence yet that epigenetic changes are involved in Crohn’s disease. The findings provide a potential mechanism whereby diet or other environmental factors may modify genetic material to cause Crohn’s disease. We hope the findings will help to identify much-needed treatment opportunities for this debilitating condition.'

Professor Jack Satsangi
Head of Gastroenterology Unit, Centre for Genomic and Experimental Medicine

Chemical changes

A study involving children with Crohn’s disease in Edinburgh, Aberdeen, and Glasgow - led by the University of Edinburgh - identified chemical changes in their DNA that affect how their genes work.
The genes that are affected by these changes could represent useful targets for new treatments, the scientists say.

Disease monitoring

A DNA test alone would not be enough to diagnose the disease but it could pinpoint those at most risk and help to reduce the number of people who are put forward for further tests, researchers say.
It could also help to monitor progression of the disease and how patients respond to treatment.

Crohn’s disease

Crohn’s disease is a type of inflammatory bowel disease and a common cause of chronic ill-health in the UK. It is a particular problem in children in Scotland, where the incidence of the disease has increased by 500 per cent in the past 50 years.

At present there is no way to prevent Crohn’s disease and therapy is focused on treating the symptoms, which may include abdominal pain, diarrhoea and severe weight loss.
The study is published in the journal Inflammatory Bowel Diseases.



Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Scientists Create CRISPR/Cas9 Knock-In Mutations in Human T Cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
Researchers Develop Vaccine that Protects Primates Against Ebola
A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola.
Universal Flu Vaccine in the Works
A new study has demonstrated a potential strategy for developing a flu vaccine with potent, broad protection.
Immunotherapy Shows Promise for Myeloma
A strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Immune System 'On Switch' Breakthrough Could Lead to Targeted Drugs
A crucial 'on switch' that boosts the body's defenses against infections has been successfully identified in new scientific research.
HIV Control Through Treatment Durably Prevents Heterosexual Transmission of Virus
NIH-funded trial proves suppressive antiretroviral therapy for HIV-infected people effective in protecting uninfected partners.
Adaptimmune's Novel Cancer Therapeutics Show Positive Clinical Trial Results
The company has announced that positive data from its Phase I/II study of its affinity enhanced T-cell receptor (TCR) therapeutic targeting the NY-ESO-1 cancer antigen in patients with multiple myeloma has been published.
Adaptimmune’s NY-ESO-1 TCR-engineered T-Cells Demonstrate Durable Persistence
Study has been published in Nature Medicine.
Iron Regulators Join War on Pathogens
Iron regulatory proteins (IRPs) play an important role in the body’s immune system.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!