|Marked increase in basophil activation during non-anaphylactic allergic reactions to peanut in man|
Paul J. Turner, Orla McMahon, Amy Switzer, Andrew Clark, Robert J. Boyle, Stephen R. Durham and Mohamed H. Shamji
Our data imply an important role for basophils in the evolution of acute IgE-mediated reactions to food allergens.
|Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis|
W Donald Cooke MD
Efficacy of sublingual immunotherapy for Juniper induced allergic rhinitis is presented.
|Association between asthma-related emergency department visits, meteorological measurements, and air quality concentrations in the Bronx (2001-2008)|
Abraham R(1), Toh J(2), Desai T(2), Shum M(3), Patel P(2), Rosenstreich D(2), Jariwala SP(2)
Evaluate the association between asthma-related emergency department visits (AREDV), meteorological measurements, and air quality concentrations in a high asthma prevalence area, the New York City borough of the Bronx.
|Ocular papillary changes on the caruncle surface in allergic conjunctivitis|
Milton M. Hom, OD, FAAO1, Leslie E. O’Dell, OD, FAAO2, Carl J. May, Jr., MD2, Leonard Bielory, MD3
The caruncle is small, pink, globular nodule at the inner corner of the eye. We found the papillary changes of the caruncle corresponds to changes in palpebral conjunctiva seen in allergic conjunctivitis. There may indicate a greater inflammatory response in the caruncle resulting in greater itching in the nasal corners of the eye. Allergists can easily assess the caruncle.
|Increasing the Generalization Capability of Biomarkers Through Systems Biology Malaria Vaccines Case Study|
Simón Perera del Rosario 1, Raquel Valls 1, Gemma Moncunill 2, Teresa Sardón 1, Carlota Dobaño 2, José Manuel Mas 1
The results underline the utility of Systems Biology (and specially Anaxomics’s TPMS) for the interpretation of high-throughput data in BM identification, with a better generalization capability than conventional methods.
|Apoplastic Venom Allergen‐like Proteins of Cyst Nematodes Modulate the Activation of Basal Plant Innate Immunity by Cell Surface Receptors|
Jose L. Lozano-Torresa, Ruud H.P. Wilbersa, SonjaWarmerdama, Anna Finkers-Tomczaka, Amalia Diaz-Granadosa, Casper C. van Schaika, Johannes Heldera, Jaap Bakkera,b, Aska Goversea,b, Arjen Schotsa and Geert Smanta,b
We conclude that parasitic nematodes most likely utilize VAPs to suppress the activation of defenses by immunogenic breakdown products in damaged host tissue.
|Non-disruptively Count and Quantify Fluorescent iPS Colonies During Secondary Reprogramming: 7 min per 6-well Plate, Dual-fluorescence Whole Well Imaging Cytometry|
SC Cribbes, S Brightwell, K Kaji
Nexcelom’s Celigo imaging cytometer has been applied to provide automated, rapid assessment of iPS reprogramming.
|Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method|
Sarah Kessel, Eric Sincoff, Olivier Dery
This study demonstrates that the cell culture assay for tumorsphere size was successfully adapted to 384-well plate for a 3D spheroid assay using U-bottom low attachment 384-well and the Celigo Automated Imager for image acquisition and analysis. Moreover, the utilization of an imager provided insight on sphere and cell fate after long term drug treatment.
|HOMOGENEOUS ADCs BEARING TWO DIFFERENT PAYLOADS SHOW STRONG SYNERGY IN TUMOR KILLING|
Lisha Allen, Yi Mi, Muhammad Abbas, Wolfgang Richter, and Sean Hu
We presented a one-pot reaction to prepare site-specific ADCs using available mABs on hand without re-engineering. We have identified a novel non-cleavable linker, which increases not only ADC stability, but also potency. We also demonstrate synergy in cancer cell killing of hybrid ADC loaded with two different toxins
|Enabling Epigenetics Studies from HTS to SAR : A Novel HTRF® Platform to Identify and Characterize Reader Domain Inhibitors|
T. Roux1, M. Badol1, N. Douayry1, L. Sergeant1, E.Trinquet1, F. Degorce1, S. Milhas2, S. Betzi2, C. Derviaux2, C. Eydoux3, J. Letienne2, A. Lugari2, Y. Collette2, J-C. Guillemot3 et X. Morelli2
Discover a novel HTRF platform to identify and characterize the vast variety of epigenetic binding domain.
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