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Non-invasive Liquid Biopsy
Frauke Henjes1, Lise Aagaard1, Darren Ellis1, Hannah Lindstroem1, Morten Oksvold2,3, Axl Neurauter1, Ketil W. Pedersen1.

Paramagnetic Dynabeads® magnetic beads provide a versatile, automation friendly tool for fast sensitive and high throughput isolation that can be tailored to isolate specific circulating biomarkers such as cells, exosomes and nucleic acids.

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Novel culture medium using a small-molecule agonist of thrombopoetin receptor
Hondo M1; Nishino T2; Inamura M1

ReproHSC medium for the culture of hematopoietic stem cells. facilitates the culture and expansion of CD34+/CD38- cells that retain their HSC properties

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Flexible automated platform for blood group genotyping on DNA microarrays
S. Paris1, D. Rigal1, V. Barlet1, M. Verdier1, N. Coudurier2, P. Bailly3, J.-C. Brès1,4

The purpose of this project was to set up and validate a flexible robotic platform using 96-well DNA microarray for multiplex blood group genotyping.

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THE MASTOCYTOSIS SOCIETY SURVEY ON MAST CELL DISORDERS: Part 2-Clinical Experiences, Co-Morbidities, Diet, Families and Opinions
aNancyRussell, DrPH, aSusanJennings, PhD, aBlairJennings, BS, aValerie Slee , RN, BSN, aLisa Sterling, BS, bMariana Castells, MD, PhD, FAAAAI,cPeter Valent, MD, bCem Akin, MD, PhD, FAAAAI

Mast cell diseases such as mastocytosis and mast cell activation syndromes involve abnormal proliferation or activation of these cells leading to many potentially debilitating symptoms. In order to determine the characteristics and experiences of people known or suspected to have a mast cell disorder, The Mastocytosis Society (TMS), a U.S. based patient advocacy, research and education organization, conducted a survey of patients.

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Safety Of A Sublingual Tablet of House Dust Mite Allergen Extracts In An Environmental Exposure Chamber Study
Michel Roux, Agnès Viatte, Robert K. Zeldin

In an environmental exposure chamber (EEC) study, treatment with HDM sublingual tablets in patients with HDM-associated allergic rhinitis was generally well tolerated regardless of dose. While asthma and related symptoms were more common during the peri-EEC challenge periods, rates did not differ between active and placebo treatment.

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Safety Of The 300 IR and 500 IR Doses Of A House Dust Mite Allergen Extracts Sublingual Tablet In Adults with Allergic Rhinitis
Hélène Nguyen, Michel Roux, Josiane Cognet-Sicé, Robert K. Zeldin

In a randomized, DBPC study in patients with HDM-associated allergic rhinitis, treatment with HDM sublingual tablets at doses of 300IR and 500IR was associated with a favorable safety profile. There was no appreciable difference in tolerability between the tested doses.

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Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM
Suzanne Kelly, PHD;Jacob Karsh, MDCM, FRCPC; Jimmy Yang, MBA; William H. Yang, MD, FRCPC, FAAAAI

Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge Theatre

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Field Performance of a New Technology with the Potential to Identify Allergy and Asthma Triggers
Julian Gordon, PhD, Prasanthi Gandhi, MBA, MPH1, Jack A.Gilbert, Jarrad T. Hampton-Marcell

This work introduces a very simple plug-and-play device that can sample air at a high volume flow rate with no moving parts. Aerosol particles are captured on electrodes and eluted for testing. We show that performance of the device is substantially equivalent to capture by pumping through a filter for immunological and molecular analysis.

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Marked increase in basophil activation during non-anaphylactic allergic reactions to peanut in man
Paul J. Turner, Orla McMahon, Amy Switzer, Andrew Clark, Robert J. Boyle, Stephen R. Durham and Mohamed H. Shamji

Our data imply an important role for basophils in the evolution of acute IgE-mediated reactions to food allergens.

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Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis
W Donald Cooke MD

Efficacy of sublingual immunotherapy for Juniper induced allergic rhinitis is presented.

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Scientific News
Finding Points To A Cause Of Chronic Lung Disease
New research explains how macrophages in the lung sometimes stick around too long, even after clearing a viral infection, leading to long-term lung problems.
Imaging Immunity
Noninvasive imaging of immune system detects tumors, could monitor therapeutic response.
Genetic Variance Explains Poor Response to Common Asthma Medications
Study opens door to new therapies for hard-to-treat children.
Triple-Negative Breast Cancer Immune Therapy
Experimental immune therapy tested in preliminary study of women with triple-negative breast cancer.
New Tool To Explore Mysteries Of The Immune System
Yale scientists use CyTOF to study a range of conditions.
VTT Printed a Morphine Test on Paper
Company use antibodies as morphine sensing molecules when creating this morphine test.
Scientists Discover Protein That Boosts Immunity to Viruses and Cancer
Researchers now developing a gene therapy designed to boost the infection-fighting cells.
Protein That Boosts Immunity To Viruses And Cancer Discovered
Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies.
Delenex Announces New Clinical Data
New clinical data show biological activity of DLX105 in patients with Behçet’s disease.
NMR ‘Fingerprinting’ for Monoclonal Antibodies
Study by NIST researchers shows the use of NMR spectroscopy for measuring the structural congfiguration of monoclonal antibodies.
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