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THE MASTOCYTOSIS SOCIETY SURVEY ON MAST CELL DISORDERS: Part 2-Clinical Experiences, Co-Morbidities, Diet, Families and Opinions
aNancyRussell, DrPH, aSusanJennings, PhD, aBlairJennings, BS, aValerie Slee , RN, BSN, aLisa Sterling, BS, bMariana Castells, MD, PhD, FAAAAI,cPeter Valent, MD, bCem Akin, MD, PhD, FAAAAI

Mast cell diseases such as mastocytosis and mast cell activation syndromes involve abnormal proliferation or activation of these cells leading to many potentially debilitating symptoms. In order to determine the characteristics and experiences of people known or suspected to have a mast cell disorder, The Mastocytosis Society (TMS), a U.S. based patient advocacy, research and education organization, conducted a survey of patients.

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Safety Of A Sublingual Tablet of House Dust Mite Allergen Extracts In An Environmental Exposure Chamber Study
Michel Roux, Agnès Viatte, Robert K. Zeldin

In an environmental exposure chamber (EEC) study, treatment with HDM sublingual tablets in patients with HDM-associated allergic rhinitis was generally well tolerated regardless of dose. While asthma and related symptoms were more common during the peri-EEC challenge periods, rates did not differ between active and placebo treatment.

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Safety Of The 300 IR and 500 IR Doses Of A House Dust Mite Allergen Extracts Sublingual Tablet In Adults with Allergic Rhinitis
Hélène Nguyen, Michel Roux, Josiane Cognet-Sicé, Robert K. Zeldin

In a randomized, DBPC study in patients with HDM-associated allergic rhinitis, treatment with HDM sublingual tablets at doses of 300IR and 500IR was associated with a favorable safety profile. There was no appreciable difference in tolerability between the tested doses.

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Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM
Suzanne Kelly, PHD;Jacob Karsh, MDCM, FRCPC; Jimmy Yang, MBA; William H. Yang, MD, FRCPC, FAAAAI

Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge Theatre

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Field Performance of a New Technology with the Potential to Identify Allergy and Asthma Triggers
Julian Gordon, PhD, Prasanthi Gandhi, MBA, MPH1, Jack A.Gilbert, Jarrad T. Hampton-Marcell

This work introduces a very simple plug-and-play device that can sample air at a high volume flow rate with no moving parts. Aerosol particles are captured on electrodes and eluted for testing. We show that performance of the device is substantially equivalent to capture by pumping through a filter for immunological and molecular analysis.

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Marked increase in basophil activation during non-anaphylactic allergic reactions to peanut in man
Paul J. Turner, Orla McMahon, Amy Switzer, Andrew Clark, Robert J. Boyle, Stephen R. Durham and Mohamed H. Shamji

Our data imply an important role for basophils in the evolution of acute IgE-mediated reactions to food allergens.

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Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis
W Donald Cooke MD

Efficacy of sublingual immunotherapy for Juniper induced allergic rhinitis is presented.

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Association between asthma-related emergency department visits, meteorological measurements, and air quality concentrations in the Bronx (2001-2008)
Abraham R(1), Toh J(2), Desai T(2), Shum M(3), Patel P(2), Rosenstreich D(2), Jariwala SP(2)

Evaluate the association between asthma-related emergency department visits (AREDV), meteorological measurements, and air quality concentrations in a high asthma prevalence area, the New York City borough of the Bronx.

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Ocular papillary changes on the caruncle surface in allergic conjunctivitis
Milton M. Hom, OD, FAAO1, Leslie E. O’Dell, OD, FAAO2, Carl J. May, Jr., MD2, Leonard Bielory, MD3

The caruncle is small, pink, globular nodule at the inner corner of the eye. We found the papillary changes of the caruncle corresponds to changes in palpebral conjunctiva seen in allergic conjunctivitis. There may indicate a greater inflammatory response in the caruncle resulting in greater itching in the nasal corners of the eye. Allergists can easily assess the caruncle.

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Scientific News
Developing a More Precise Seasonal Flu Vaccine
During the 2014-15 flu season, the poor match between the virus used to make the world’s vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.
Fighting Cancer with Borrowed Immunity
A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might.
Loss Of Y Chromosome Increases Risk Of Alzheimer’s
Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease. This is in addition to an increased risk of death from other causes, including many cancers. These new findings by researchers at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.
Immune Cells Remember Their First Meal
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases.
"Sunscreen" Gene May Guard Against Melanoma
USC-led study reveals that melanoma patients with deficient or mutant copies of the gene are less protected from harmful ultraviolet rays.
Myeloid-Derived Suppressor Cells Play Role in Tumor Growth
Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.
Drug Might Help Treat Sepsis
A DNA enzyme called Top1 plays a key role in turning on genes that cause inflammation in mouse and human cells in response to pathogens. A drug blocking this enzyme rescued mice from lethal inflammatory responses, suggesting a potential treatment for sepsis.
Large-scale HIV Vaccine Trial to Launch in South Africa
NIH-funded study will test safety, efficacy of vaccine regimen.
Immune System Implicated in Gastroschisis
UCSF researchers show that the immune system is implicated in gastroschisis. The findings could lead to improved treatments for the belly birth defect.
Hay Fever's Hidden Supporting Substances
TUM study finds that non-allergenic substances in pollen heighten the immune response.
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