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Marked increase in basophil activation during non-anaphylactic allergic reactions to peanut in man
Paul J. Turner, Orla McMahon, Amy Switzer, Andrew Clark, Robert J. Boyle, Stephen R. Durham and Mohamed H. Shamji

Our data imply an important role for basophils in the evolution of acute IgE-mediated reactions to food allergens.

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Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis
W Donald Cooke MD

Efficacy of sublingual immunotherapy for Juniper induced allergic rhinitis is presented.

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Association between asthma-related emergency department visits, meteorological measurements, and air quality concentrations in the Bronx (2001-2008)
Abraham R(1), Toh J(2), Desai T(2), Shum M(3), Patel P(2), Rosenstreich D(2), Jariwala SP(2)

Evaluate the association between asthma-related emergency department visits (AREDV), meteorological measurements, and air quality concentrations in a high asthma prevalence area, the New York City borough of the Bronx.

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Ocular papillary changes on the caruncle surface in allergic conjunctivitis
Milton M. Hom, OD, FAAO1, Leslie E. O’Dell, OD, FAAO2, Carl J. May, Jr., MD2, Leonard Bielory, MD3

The caruncle is small, pink, globular nodule at the inner corner of the eye. We found the papillary changes of the caruncle corresponds to changes in palpebral conjunctiva seen in allergic conjunctivitis. There may indicate a greater inflammatory response in the caruncle resulting in greater itching in the nasal corners of the eye. Allergists can easily assess the caruncle.

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Microbial Regulation of IgE Production in Early Life
Ana B Blazquez, Jeremiah J Faith, Hugh A Sampson, M Cecilia Berin

Changes in gastrointestinal microbiota have been suggested to drive the increasing prevalence of food allergy. Our aim was to determine the impact of mouse and human intestinal microbiota on modulation of allergic parameters including IgE.

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Tolerance to Allergenic Foods Following Food Oral Immunotherapy (FOIT)
AR Hague1, RL Wasserman1,2, SK Silvers1,2, RW Sugerman1,2, M Herbert3

We report on 21 patients who completed FOIT (food oral immunotherapy) escalation followed by a period of maintenance dosing and later underwent a tolerance FC (food challenge). 90% of tested FOIT patients and 94% of patients who met our pre-defined criteria for tolerance FC achieved tolerance to their allergenic food.

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Single Practice Six-Year Experience Treating Food Allergy With Oral Immunotherapy
DM Pence1, AR Hague1, RL Wasserman1,2, SK Silvers1,2, RW Sugerman1,2, M Herbert3

We report a more-than-six-year experience with food oral immunotherapy (FOIT) in a private allergy practice setting. Most patients can be desensitized to one or more allergenic foods. Ongoing evaluation and modification of the FOIT procedures improves outcomes and acceptability. FOIT can be successfully performed in an allergy office.

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Peanut Allergy: An epidemiologic analysis of a large database
Leickly, FE, Vitapur, G, and Kloepfer, K

Over three years, 700 children with a peanut story - either peanut sensitization or peanut allergy- were asked to participate in a database.

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Increasing the Generalization Capability of Biomarkers Through Systems Biology Malaria Vaccines Case Study
Simón Perera del Rosario 1, Raquel Valls 1, Gemma Moncunill 2, Teresa Sardón 1, Carlota Dobaño 2, José Manuel Mas 1

The results underline the utility of Systems Biology (and specially Anaxomics’s TPMS) for the interpretation of high-throughput data in BM identification, with a better generalization capability than conventional methods.

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Showing Results 11 - 20 of 54
Scientific News
A New Path Towards a Universal Flu Vaccine
New research suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.
$1.35 Million Grant to Better Predict Flu Outbreaks
An international research team will receive $1.35 million from the Human Frontier Science Program Organization to better understand how the influenza virus passes from birds to humans.
Too Exhausted to Fight – and to do Harm
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Engineered particles are capable of producing toxins that are deadly to targeted bacteria.
Iron: A Biological Element?
Study shows findings which have meaning for fields as diverse as mining and the search for life in space.
Team Led by TSRI Scientists Shows AIDS Vaccine Candidate Successfully ‘Primes’ Immune System
New research shows that an experimental vaccine candidate can stimulate immune activity necessary to prevent HIV infection.
New Tool Identifies Novel Compound Targeting Causes of Type 2 Diabetes
Study identifies small-molecule compound that protects cells against ER stress.
New Immunoregulation and Biomarker
Clinicians at LMU have elucidated a mechanism involved in determining the lifespan of antibody-producing cells, and identified a promising new biomarker for monitoring autoimmune diseases.
Seashells to Deliver New Drugs and Vaccines
Australian scientists have developed a protective seashell-inspired capsule to preserve the active biological ingredients needed to create new drugs.
HIV Paradox
Investigators from Harvard Medical School, Massachusetts General Hospital, and the Ragon Institute of MGH, MIT and Harvard have added another piece to the puzzle of how a small group of individuals known as elite controllers are able to control HIV infection without drug treatment.
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