The MaxDiscovery™ Human GM-CSF ELISA Test Kit is designed for quantitative determination of the concentration of human GM-CSF in serum, plasma, and cell culture supernatant. Human granulocyte/monocyte-colony stimulating factor (GM-CSF) is a 14 kDa protein composed of 127 amino acids. It was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-a, IL-1, IL-2 and IFN-?. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too. GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.
Food Triggers Creation of Regulatory T Cells IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.Therapeutic Approach Gives Hope for Multiple Myeloma A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.Switch Lets Salmonella Fight, Evade Immune System Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.Tricked-Out Immune Cells Could Attack Cancer New cell-engineering technique may lead to precision immunotherapies.Neural Networks Adapt to the Presence of a Toxic HIV Protein HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIV infected patients.HIV Protein Manipulates Hundreds of Human Genes Findings search for new or improved treatments for patients with AIDS.Breaking the Brain’s Garbage Disposal The children’s ataxia gene problem turned out to be not such a big deal genetically — it was such a slight mutation that it barely changed the way the cells made the protein. Flesh-Eating Bacteria Work Together Scientists recently discovered different strains of deadly flesh-eating bacteria working together to spread infection and they now have a better understanding of the role of the toxins they produce. The discovery could change how the illness and other diseases are treated.Utilizing Antibodies from Ebola Survivors A collaborative team from The University of Texas Medical Branch at Galveston, Vanderbilt University, The Scripps Research Institute and Integral Molecular Inc. have learned that antibodies in the blood of people who have survived a strain of the Ebola virus can kill various types of Ebola.