The MaxDiscovery™ Human IL-10 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-10 in serum, plasma, and cell culture supernatant. Human interleukin 10 (IL-10) is a homodimeric protein with subunits having a length of 160 amino acids. It shows 73 percent amino acid homology with murine IL-10. It is produced by activated CD8 + peripheral blood T cells, by T-helper CD4 + T cell clones after both antigen-specific and polyclonal activation, by B-cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. IL-10 inhibits the synthesis of a number of cytokines such as IL-2 and TNF-ß in Th1 T-helper cells but not of Th2 T-helper cells. IL-10 also inhibits mitogen or anti-CD3 induced proliferation of T cells in the presence of accessory cells and reduces the production of IFN-? and IL-2.
Getting a Better Look at How HIV Infects and Takes Over its Host Cells A new approach, developed by a team of researchers led by The Rockefeller University and The Aaron Diamond AIDS Research Center (ADARC), offers an unprecedented view of how a virus infects and appropriates a host cell, step by step. Untangling Disease-Related Protein Misfolding Work advances understanding of genetic forms of thrombosis, emphysema, cirrhosis of the liver, neurodegenerative diseases and inflammation, among others.Developing a More Precise Seasonal Flu Vaccine During the 2014-15 flu season, the poor match between the virus used to make the world’s vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.Fighting Cancer with Borrowed Immunity A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might. Loss Of Y Chromosome Increases Risk Of Alzheimer’s Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease. This is in addition to an increased risk of death from other causes, including many cancers. These new findings by researchers at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.Immune Cells Remember Their First Meal Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases."Sunscreen" Gene May Guard Against Melanoma USC-led study reveals that melanoma patients with deficient or mutant copies of the gene are less protected from harmful ultraviolet rays.Myeloid-Derived Suppressor Cells Play Role in Tumor Growth Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.Drug Might Help Treat Sepsis A DNA enzyme called Top1 plays a key role in turning on genes that cause inflammation in mouse and human cells in response to pathogens. A drug blocking this enzyme rescued mice from lethal inflammatory responses, suggesting a potential treatment for sepsis.Large-scale HIV Vaccine Trial to Launch in South Africa NIH-funded study will test safety, efficacy of vaccine regimen.