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 | Robust Three-dimensional Tools to Design Inhibitors Against Drug Targets Which Lack Explicit Specificity Dr. Moses Mohandas Prabu, The Commonwealth Medical College, speaking at Discovery Chemistry Congress 2013. |
 | Discovery of Cancer Drug Targets using RNAi Screening with Pooled Lentiviral shRNA Libraries Alex Chenchik, Cellecta Inc, speaking at Genomics Research Europe 2012 |
Benchtop Automation Trends 2013
HTStec
This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014)
MarketsandMarkets
The market for bioinformatics platforms is growing at a significant pace with the increasing demand from U.S. and Europe. This trend is supported by the increasing demand for sequencing platforms with increasing life science research using techniques such as gene expression analysis, sequence analysis, and protein expression analysis.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights
This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
HTStec
This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014)
MarketsandMarkets
The market for bioinformatics platforms is growing at a significant pace with the increasing demand from U.S. and Europe. This trend is supported by the increasing demand for sequencing platforms with increasing life science research using techniques such as gene expression analysis, sequence analysis, and protein expression analysis.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights
This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
Agilent Technologies Announces Winner of Fifth Annual Early Career Professor Award
Assistant Professor at Northwestern Recognized for Cancer Diagnostics Research.
Launch of £90m Initiative in Big Data and Drug Discovery at Oxford University
'Big data' to revolutionise healthcare.
HealthLinkNow Integrates SBR Health
HLN and SBR announced HLN has selected SBR’s video call routing and management solution to manage virtual patient-provider visits on HLN’s telemedicine network.
Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines
NIAID-funded investigators develop interactive web applications to share data with peers.
Gifts to Boost University of Chicago as Hub for Biomedical 'Big Data'
Two major gifts will build momentum behind the University of Chicago’s leadership in biomedical computation.
Researchers Develop Animal Free Methods for Testing Chemical Compounds for Allergens
EU-funded research project developing in vitro (‘out of body’) test strategies to reduce or replace animal testing use gene expression analysis software.
A Molecular-Modeling Toolbox Aimed at Bridging the Gap Between Medicinal Chemistry and Computational Sciences
Researchers from the University of Basel have designed a versatile single-click tools to assist medicinal chemists in performing two routine modeling tasks.
Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics
This study explores a new approach to seeking biomarkers for prostate cancer and other diseases.
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Assistant Professor at Northwestern Recognized for Cancer Diagnostics Research.
Launch of £90m Initiative in Big Data and Drug Discovery at Oxford University
'Big data' to revolutionise healthcare.
HealthLinkNow Integrates SBR Health
HLN and SBR announced HLN has selected SBR’s video call routing and management solution to manage virtual patient-provider visits on HLN’s telemedicine network.
Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines
NIAID-funded investigators develop interactive web applications to share data with peers.
Gifts to Boost University of Chicago as Hub for Biomedical 'Big Data'
Two major gifts will build momentum behind the University of Chicago’s leadership in biomedical computation.
Researchers Develop Animal Free Methods for Testing Chemical Compounds for Allergens
EU-funded research project developing in vitro (‘out of body’) test strategies to reduce or replace animal testing use gene expression analysis software.
A Molecular-Modeling Toolbox Aimed at Bridging the Gap Between Medicinal Chemistry and Computational Sciences
Researchers from the University of Basel have designed a versatile single-click tools to assist medicinal chemists in performing two routine modeling tasks.
Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics
This study explores a new approach to seeking biomarkers for prostate cancer and other diseases.
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Simulations Plus Software Used in Regulatory Submittals
US FDA, UK MHRA, and European EMA accept simulation results in applications.
Scale-up Systems and ScienView Team Up on Process Development
The developers of DynoChem® aim to accelerate process development in Chinese pharmaceutical industry.
Instem Enters Early Phase Clinical Market
Instem has acquired Logos Technologies representing its strategic move into the early phase clinical trials market.
Liaison Healthcare Launches Global CRO Integration Hub
New cloud-based solution facilitates information exchange during clinical trial process.
Promium Awarded National LIMS Contract from Environment Canada
Environment Canada to implement Element LIMS for national network of environmental laboratories.
Core Informatics and OpenEye Scientific Software Forge Partnership
New partnership integrates OpenEye cheminformatics software into Core Informatics' web-based LIMS and ELN
RURO Releases White Paper on Creating the Modern Laboratory with LIMS 24/7
White paper outlines key challenges faced by laboratory managers
Mount Sinai Selects Exemplar LIMS for Genomics Core Facility
Exemplar LIMS utilized for Mount Sinai CLIA-certified Genomics Core Facility employing diverse NGS platforms
Autoscribe reports significant business growth
Autoscribe experiences 131% growth in the first quarter of 2013.
Life Technologies Announces First Quarter 2013 Results
Revenue increased 2.5% to $963 million.
US FDA, UK MHRA, and European EMA accept simulation results in applications.
Scale-up Systems and ScienView Team Up on Process Development
The developers of DynoChem® aim to accelerate process development in Chinese pharmaceutical industry.
Instem Enters Early Phase Clinical Market
Instem has acquired Logos Technologies representing its strategic move into the early phase clinical trials market.
Liaison Healthcare Launches Global CRO Integration Hub
New cloud-based solution facilitates information exchange during clinical trial process.
Promium Awarded National LIMS Contract from Environment Canada
Environment Canada to implement Element LIMS for national network of environmental laboratories.
Core Informatics and OpenEye Scientific Software Forge Partnership
New partnership integrates OpenEye cheminformatics software into Core Informatics' web-based LIMS and ELN
RURO Releases White Paper on Creating the Modern Laboratory with LIMS 24/7
White paper outlines key challenges faced by laboratory managers
Mount Sinai Selects Exemplar LIMS for Genomics Core Facility
Exemplar LIMS utilized for Mount Sinai CLIA-certified Genomics Core Facility employing diverse NGS platforms
Autoscribe reports significant business growth
Autoscribe experiences 131% growth in the first quarter of 2013.
Life Technologies Announces First Quarter 2013 Results
Revenue increased 2.5% to $963 million.
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Identification and Characterization of Strain Specific Drug Target by Subtractive Genome Analysis of Methicillin Resistance Staphylococcus aureus
University of Karachi
This study aimed to identify and characterize strain specific essential protein targets, which will eventually help in the identification of druggable proteins in two strains of MRSA by using different Bioinformatic tools and databases. We adopting a subtractive genome approach within the domain of Computational Biology.
Reaxys Xcelerate – Less Searching. More Discovery
Reed Elsevier
Reaxys Xcelerate is a new premium version of Reaxys. Reaxys is a web based workflow tool for synthetic chemists. It is designed to support the optimization of synthetic processes and offers a valuable resource for accurate & validated experimental reaction & substance data.
Processing and Managing Analytical Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Effective Use of In-Silico Tools in Lead Optimization
ACD Labs
Of all the challenges facing medicinal chemists in general, one of the most significant must be transforming an active molecule into a viable drug. Lead optimization efforts are guided by a combination of factors, such as potency, ease of synthesis, patentability concerns, specific synthetic constrains of the interaction with the target, as well as the lead’s toxicity and ADME properties.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants
ACD Labs
This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
University of Karachi
This study aimed to identify and characterize strain specific essential protein targets, which will eventually help in the identification of druggable proteins in two strains of MRSA by using different Bioinformatic tools and databases. We adopting a subtractive genome approach within the domain of Computational Biology.
Reaxys Xcelerate – Less Searching. More Discovery
Reed Elsevier
Reaxys Xcelerate is a new premium version of Reaxys. Reaxys is a web based workflow tool for synthetic chemists. It is designed to support the optimization of synthetic processes and offers a valuable resource for accurate & validated experimental reaction & substance data.
Processing and Managing Analytical Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Effective Use of In-Silico Tools in Lead Optimization
ACD Labs
Of all the challenges facing medicinal chemists in general, one of the most significant must be transforming an active molecule into a viable drug. Lead optimization efforts are guided by a combination of factors, such as potency, ease of synthesis, patentability concerns, specific synthetic constrains of the interaction with the target, as well as the lead’s toxicity and ADME properties.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants
ACD Labs
This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation
This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
Waters Corporation
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation
This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
