Thursday, May 17, 2012
Technology Networks
Technology Networks
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 | Functional Interrogation of 'omics' Data Dr Kartiki V Desai, National Insitute of Biomedical Genomics, speaking at Screening Asia 2011. |
 | Utilising Informatics to Add Value to Banked Samples Jane Rogan, Manchester Cancer Research Centre Biobank, speaking at World Biobanking Summit 2011. |
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014)
MarketsandMarkets
The market for bioinformatics platforms is growing at a significant pace with the increasing demand from U.S. and Europe. This trend is supported by the increasing demand for sequencing platforms with increasing life science research using techniques such as gene expression analysis, sequence analysis, and protein expression analysis.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights
This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014)
MarketsandMarkets
The market for bioinformatics platforms is growing at a significant pace with the increasing demand from U.S. and Europe. This trend is supported by the increasing demand for sequencing platforms with increasing life science research using techniques such as gene expression analysis, sequence analysis, and protein expression analysis.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights
This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
Interfacing Medicinal Chemistry with Structural Bioinformatics
The observed aaRS-specific stability differences between key riboswitch structural elements could potentially be targeted to effect ligand-specificity in future drug discovery efforts.
National Data Center for Cancer Genome Research
In the wake of personalized medicine, scientists at the University of California, Santa Cruz, make progress in the management and analysis of large data sets.
Researchers Turn Big Data Problems into Advanced Biology and Drug Discoveries
University of Illinois at Chicago and The Genome Analysis Centre in Norwich, UK leverage SGI(R) UV(TM) to accelerate drug discovery and complex problem analysis.
New Pathogen Resource Launched
PhytoPath to help researchers find ways to combat agricultural pathogens.
Disease Model Curation Improvements at Mouse Genome Informatics
This paper evaluates the Comparative Toxicogenomics Database (CTD) and discusses its strengths and weaknesses.
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
This paper provides an overview of the data processing tools available, offering a review of the collection of recent reports on the topic.
Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug Design
The group of scientists performed structural analyses on biologically important molecules and their complexes with partners, hoping to contribute to molecular design for controlling biologically abnormal functions.
Biogem: an Effective Tool Based Approach for Scaling up Open Source Software Development in Bioinformatics
To help encourage developers to contribute more code, Biogem was created; a Ruby application framework for rapid creation of decentralised, internet published software modules written to lower the barrier to entry.
Recent Advances of Metabolomics in Plant Biotechnology
This article describes the basic analytical advancements in plant metabolomics and bioinformatics and the application of metabolomics to the biological study of plants.
SRI Speeds Development of Genome-Scale Models of Metabolic Networks
The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
The observed aaRS-specific stability differences between key riboswitch structural elements could potentially be targeted to effect ligand-specificity in future drug discovery efforts.
National Data Center for Cancer Genome Research
In the wake of personalized medicine, scientists at the University of California, Santa Cruz, make progress in the management and analysis of large data sets.
Researchers Turn Big Data Problems into Advanced Biology and Drug Discoveries
University of Illinois at Chicago and The Genome Analysis Centre in Norwich, UK leverage SGI(R) UV(TM) to accelerate drug discovery and complex problem analysis.
New Pathogen Resource Launched
PhytoPath to help researchers find ways to combat agricultural pathogens.
Disease Model Curation Improvements at Mouse Genome Informatics
This paper evaluates the Comparative Toxicogenomics Database (CTD) and discusses its strengths and weaknesses.
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
This paper provides an overview of the data processing tools available, offering a review of the collection of recent reports on the topic.
Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug Design
The group of scientists performed structural analyses on biologically important molecules and their complexes with partners, hoping to contribute to molecular design for controlling biologically abnormal functions.
Biogem: an Effective Tool Based Approach for Scaling up Open Source Software Development in Bioinformatics
To help encourage developers to contribute more code, Biogem was created; a Ruby application framework for rapid creation of decentralised, internet published software modules written to lower the barrier to entry.
Recent Advances of Metabolomics in Plant Biotechnology
This article describes the basic analytical advancements in plant metabolomics and bioinformatics and the application of metabolomics to the biological study of plants.
SRI Speeds Development of Genome-Scale Models of Metabolic Networks
The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
European Life Science Awards Nominees Announced
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
Abbott’s STARLIMS Business Acquires Distribution Partners to Build International Presence
Acquisitions part of a series of strategic moves to build Abbott's LIMS business in Europe and emerging markets in Latin America and Africa
Frost & Sullivan gives an overview of the Global Automated Biobanking market
Robotics to aid and drive long term vision of truly personalised medicine
Novozymes and Syngenta to partner in delivering JumpStart® — For enhanced phosphate fertility within bioagriculture
The agreement provides an exclusive expansion into new markets for JumpStart, which is a biological that enhances phosphate fertility in agriculture, offering growers an integrated and sustainable seed care solution
Shengquan and Novozymes in partnership to commercialize cellulosic ethanol
The Chinese Shengquan Group will start commercial production of cellulosic ethanol for solvents and biochemicals in June 2012 utilizing enabling technology from Novozymes
Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement
Agreement designed to provide users next-gen sequencing software tools.
Neogen acquires Igenity from Merial
Igenity will operate as a part of Neogen's GeneSeek subsidiary, which already has a significant place in the worldwide animal genomics business.
Genome Designs Partners with SciDM Group
Securing high performance bioinformatics tools for internal pipelines and custom projects.
European Manufacturing Giant Selects Labvantage
European manufacturing giant has selected Labvantage Solutions' LIMS solution to replace its existing LIMS.
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
Abbott’s STARLIMS Business Acquires Distribution Partners to Build International Presence
Acquisitions part of a series of strategic moves to build Abbott's LIMS business in Europe and emerging markets in Latin America and Africa
Frost & Sullivan gives an overview of the Global Automated Biobanking market
Robotics to aid and drive long term vision of truly personalised medicine
Novozymes and Syngenta to partner in delivering JumpStart® — For enhanced phosphate fertility within bioagriculture
The agreement provides an exclusive expansion into new markets for JumpStart, which is a biological that enhances phosphate fertility in agriculture, offering growers an integrated and sustainable seed care solution
Shengquan and Novozymes in partnership to commercialize cellulosic ethanol
The Chinese Shengquan Group will start commercial production of cellulosic ethanol for solvents and biochemicals in June 2012 utilizing enabling technology from Novozymes
Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement
Agreement designed to provide users next-gen sequencing software tools.
Neogen acquires Igenity from Merial
Igenity will operate as a part of Neogen's GeneSeek subsidiary, which already has a significant place in the worldwide animal genomics business.
Genome Designs Partners with SciDM Group
Securing high performance bioinformatics tools for internal pipelines and custom projects.
European Manufacturing Giant Selects Labvantage
European manufacturing giant has selected Labvantage Solutions' LIMS solution to replace its existing LIMS.
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Processing and Managing Analytical Data to Extract Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Effective Use of In-Silico Tools in Lead Optimization
ACD Labs
Of all the challenges facing medicinal chemists in general, one of the most significant must be transforming an active molecule into a viable drug. Lead optimization efforts are guided by a combination of factors, such as potency, ease of synthesis, patentability concerns, specific synthetic constrains of the interaction with the target, as well as the lead’s toxicity and ADME properties.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants
ACD Labs
This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Understanding the Role of Quality by Design in Chromatographic Method Development
ACD Labs
Quality by Design (QbD) has become popular within the pharmaceutical industry and the FDA has cited a risk-based approach to drug development as a desirable state for the near future.1 In this state, more complete information and transparency relating to risk assessment will be made available for new drug aplications speeding the approval process, and preventing late-stage failures.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Effective Use of In-Silico Tools in Lead Optimization
ACD Labs
Of all the challenges facing medicinal chemists in general, one of the most significant must be transforming an active molecule into a viable drug. Lead optimization efforts are guided by a combination of factors, such as potency, ease of synthesis, patentability concerns, specific synthetic constrains of the interaction with the target, as well as the lead’s toxicity and ADME properties.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants
ACD Labs
This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Understanding the Role of Quality by Design in Chromatographic Method Development
ACD Labs
Quality by Design (QbD) has become popular within the pharmaceutical industry and the FDA has cited a risk-based approach to drug development as a desirable state for the near future.1 In this state, more complete information and transparency relating to risk assessment will be made available for new drug aplications speeding the approval process, and preventing late-stage failures.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
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