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Webcasts
Managing Pharmaceutical Lab Data Management to Ensure Compliance
Join Stacey Brown and William Leonard, Senior Validation Analysts for Informatics at Thermo Fisher Scientific, to understand more about the complex requirements of pharmaceutical data management.
15 Years HCS: Next Gen Screening Devices Learn from Each Other. Literally. Fast Workflow Development & BigData Image Analytics Used to be a Challenge. What’s Next?
Urban Liebel, ACQUIFER, speaking at Screening Europe 2015

Market Reports
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights

This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
Scientific News
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
‘Lifespan Machine’ Probes Cause of Aging
Findings suggest that aging has no single mechanism.
Machine Learning Uncovers Unknown Bacterial Features
Technique robustly identified characteristic gene expression patterns in response to antibiotics, low oxygen conditions.
Nucleic Acid Computing Inside Cells
Using strands of nucleic acid, scientists have demonstrated basic computing operations inside a living mammalian cell.
Risk Map for Nematode Parasite in Uganda
Infection with the nematode parasite Mansonella perstans is one of the most neglected of the neglected tropical diseases.
DNA Analysis in the Fast Lane
Rice bioengineers' method should lead to better database of thermal behaviors.
Mapping out Cell Conversion
Researchers develop algorithm that takes the field of cell reprogramming forward.
Parallel Single-Cell Profiling
New single-cell genomics protocol allows researchers to study links between DNA modifications (methylation) and the activity of a gene.
ASCB: A CELLebration of Cell Biology
The last major congress of the year, ASCB is less a platform for launching new products, but one for confirming and consolidating the trends that have emerged over the past 12 months.
Three Glaucoma-Related Genes Discovered
NIH-funded genetics analysis of glaucoma is largest to date.
Business News
DNAnexus, Sapio Collaborate
DNAnexus Inc., the global leader in cloud-based genome informatics and data management, has announced the integration of its cloud-based genomics platform with Sapio Sciences’ Exemplar Next Generation Sequencing (NGS) Laboratory Information Management System (LIMS) solution for clinical and research labs.
Coimbra Genomics Seals Six Partnerships for Global Expansion
Precision Medicine start-up Coimbra Genomics has unveiled today a set of global alliances that will bring its breakthrough software, ELSIE®, to the hands of physicians at some of the most advanced hospitals around the World.
PerkinElmer Signals™ Perspectives Launches in Collaboration with Attivio
New data discovery solution leverages Attivio's platform to provide insight into complex scientific challenges.
Significant Savings by Utilizing Freezerworks as LIMS
Dataworks Development, Inc. has released a case study detailing how Genocea Biosciences is enjoying significant cost and time savings in LIMS application by utilizing Freezerworks, its sample management software program, to also manage clinical test result data.
Pints and PhDs
On Tuesday 26 January, three scientists from The Genome Analysis Centre (TGAC) helped kick-off the first installment of ‘PubhD’ at the Cellar House in Eaton, Norwich.
Venaxis Announces Transaction with Strand Life Sciences
Venaxis®, Inc. has announced that it has entered into a series of agreements for a transaction with Strand Life Sciences Private Limited (Strand LS) and its shareholders.
ACD/Labs Celebrates 500th Customer in Asia & Pacific Region
ACD/Labs customers provide their unique perspectives on solutions deployed and used over the last decade.
Domainex, Cresset Announce Drug Discovery Services Alliance
Domainex Ltd., a small-molecule drug discovery company, and Cresset Discovery Services, a services company for small molecule discovery and design, have announced an alliance to provide their customers with world-class laboratory-based and computational drug discovery services through a seamless combination of their respective capabilities in chemistry and biology.
FactBio Joins Pistoia Alliance
FactBio, a developer of novel bioinformatics software with a focus on improving knowledge management and data sharing, has joined the Pistoia Alliance, a global organisation supporting life sciences R&D.
LindaCare Signs Collaboration Agreement with UZ Leuven
Collaboration aims to improve tele-monitoring follow-up of patients with chronic heart disease with Cardiac Implanted Electronic Devices (CIED).

Events
SmartLab Exchange Europe 2016
09 Feb 2016
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23 Feb 2016
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Pittcon 2016
06 Mar 2016
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ePosters
Predicting Regioselectivityand Labilityof Cytochrome P450 Metabolism using Quantum Mechanical Simulations
Optibrium

Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism using Quantum Mechanical Simulations
The Power Decoder simulator for the evaluation of pooled shRNA screen performance
GE Healthcare Dharmacon, Inc.

Power Decoder (written in R and Python) simulates shRNA pooled screening experiments in silico to allow for the estimation of a screen’s statistical power. Populations of shRNAs were engineered in such a way that the magnitude of depletion and enrichment was known, then using the negative binomial distribution, an in silico model was developed to successfully resemble data from an actual laboratory experiment.
Knockdown of long noncoding RNAs in breast cancer
GE Healthcare Dharmacon, Inc.

RNAi global collaboration study using Lincode siRNA in a primary screen of tumor and nontumor breast cell lines. Hundreds of lncRNAs are found to affect viability and cell morphology of breast cancer. Presented at Keystone Symposia on Long Noncoding RNAs: From Evolution to Function, Mar 15 - Mar 20, 2015.
Specificity of highly potent miRNA inhibitors
GE Healthcare Dharmacon, Inc.

miRNA inhibitors are invaluable tools for elucidating the roles of miRNAs. However, potent inhibitors may also affect other miRNAs. To understand the potential cross-reactivity of miRNA inhibitors, various miRNA inhibitor designs were systematically tested. We demonstrate that mismatches both within and outside the seed region of the miRNA interfere with inhibition. Our findings indicate that features important for natural miRNA target recognition are also important for inhibitor specificity.
Alternative miRNA design for therapeutic RNAi applications
GE Healthcare Dharmacon, Inc.

For in vivo applications, the design of miRNA inhibitors and miRNA mimics must be optimized for stability and potency. However, stabilized miRNA mimic molecules can lose functionality compared to standard miRNA mimic molecules due, in part, to the activity of the stabilized passenger strand acting as a miRNA inhibitor. We discuss how mismatches affect the activity of the stabilized miRNA mimics, perhaps by generating a passenger strand that is less functional as an inhibitor molecule.
Cas9 driven by an optimal promoter improves gene editing in eukaryotic cell lines when paired with synthetic crRNA and tracrRNA
GE Healthcare Dharmacon, Inc.

Presented here are results on the efficiency of using synthetic crRNA and tracrRNA to introduce gene editing events when co-transfected with a plasmid expressing Cas9. We explored the use of antibiotic and fluorescence activated cell sorting (FACS) methods for enrichment of cells that have undergone gene editing, and the use of multiple promoters to increase efficiency of gene editing with Cas9 and synthetic tracrRNA and crRNAs.
Specificity and functionality of microRNA inhibitors
GE Healthcare Dharmacon, Inc.

Our findings indicate that features important for natural miRNA target recognition also appear to be important for inhibitor specificity. Understanding the specificity of inhibitors allows for better interpretation of inhibitor activity in endogenous systems.
Identification of microRNA targets using microRNA modulation techniques and gene expression arrays
GE Healthcare Dharmacon, Inc.

By examining the overlap of messages down-regulated by miRNA mimics and up-regulated by miRNA inhibitors, we robustly identify miRNA-regulated messages, many of which have canonical seed matches and some which are not identied by standard target prediction programs.
siRNA Screening: Development of Hit Stratification Strategies
GE Healthcare Dharmacon, Inc.

This poster compares different approaches to hit stratification and validation after an initial screen. Standard siRNA reagents deconvoluted from a pooled set of four were compared to a pooled set of four specificity enhanced reagents. High confidence hits were similar. To explore the validity of low confidence hits, a chimeric approach was used whereby a gene-specific seed sequence was introduced into a non-targeting siRNA scaffold. This work resulted in new hit stratification strategies.
The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry
GE Healthcare Dharmacon, Inc.

Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
Application Notes
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation

Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation

This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific

Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies

The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation

As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
SELECTBIO

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