Thursday, February 23, 2012
Technology Networks
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 | State-of-the-Art in Ligand-Based Virtual Screening Jürgen Bajorath, Professor, Department of Life Science Informatics, University of Bonn, speaking at Medchem Europe 2011. |
 | Enhancing Success Rates in Virtual Screening Giulio Rastelli, Associate Professor in Medicinal Chemistry at the University of Modena, speaking at Medchem Europe 2011. |
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014)
MarketsandMarkets
The market for bioinformatics platforms is growing at a significant pace with the increasing demand from U.S. and Europe. This trend is supported by the increasing demand for sequencing platforms with increasing life science research using techniques such as gene expression analysis, sequence analysis, and protein expression analysis.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights
This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014)
MarketsandMarkets
The market for bioinformatics platforms is growing at a significant pace with the increasing demand from U.S. and Europe. This trend is supported by the increasing demand for sequencing platforms with increasing life science research using techniques such as gene expression analysis, sequence analysis, and protein expression analysis.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights
This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
Recent Advances of Metabolomics in Plant Biotechnology
This article describes the basic analytical advancements in plant metabolomics and bioinformatics and the application of metabolomics to the biological study of plants.
SRI Speeds Development of Genome-Scale Models of Metabolic Networks
The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
Complete Genomics Publishes Paper Describing Its Informatics Approach for High-Accuracy Whole Human Genome Sequencing
The Journal of Computational Biology has published online the company's paper describing some of the computational methods that enable it to produce such accurate data.
Medicinal Genomics Introduces an iPad App to Explore the Science of Medical Marijuana
Medicinal Genomics announced the availability of Jane-Ome, an application designed for Apple's iPad tablet, which offers a science-based dissection of medical marijuana.
New Silicon Probe Assists in Disease Diagnostics and Drug Discovery
Scientists have developed a flexible, non-contact microfluidic probe made from silicon that can aid researchers and pathologists to investigate critical tissue samples accurately, reducing the need for large biopsy samples.
Every Cloud has a Silver Lining: Weather Forecasting Models could Predict Brain Tumor Growth
An innovative new study published in Biology Direct has determined that the mathematical methodology used to assimilate data for weather forecasting could be used to predict the spread of brain tumors.
SCYNEXIS and Medicines for Malaria Venture (MMV) Sign HEOS® Agreement
The software is a comprehensive, web-based drug research information management system that supports geographically distributed scientists and facilitates collaboration.
Statistical Evaluation of Improvement in RNA Secondary Structure Prediction
With discovery of diverse roles for RNA, its centrality in cellular functions has become increasingly apparent. A number of algorithms have been developed to predict RNA secondary structure.
ATL and EnvironmentalReports Partner
Partnership aims to provide laboratories with the ability to manage all operational data and easily achieve regulatory compliance goals
Exemplar LIMS Accelerates Mitomics CLIA Certification and Serves as Foundation of Operations
Phase One of the project encompassed a large scope
This article describes the basic analytical advancements in plant metabolomics and bioinformatics and the application of metabolomics to the biological study of plants.
SRI Speeds Development of Genome-Scale Models of Metabolic Networks
The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
Complete Genomics Publishes Paper Describing Its Informatics Approach for High-Accuracy Whole Human Genome Sequencing
The Journal of Computational Biology has published online the company's paper describing some of the computational methods that enable it to produce such accurate data.
Medicinal Genomics Introduces an iPad App to Explore the Science of Medical Marijuana
Medicinal Genomics announced the availability of Jane-Ome, an application designed for Apple's iPad tablet, which offers a science-based dissection of medical marijuana.
New Silicon Probe Assists in Disease Diagnostics and Drug Discovery
Scientists have developed a flexible, non-contact microfluidic probe made from silicon that can aid researchers and pathologists to investigate critical tissue samples accurately, reducing the need for large biopsy samples.
Every Cloud has a Silver Lining: Weather Forecasting Models could Predict Brain Tumor Growth
An innovative new study published in Biology Direct has determined that the mathematical methodology used to assimilate data for weather forecasting could be used to predict the spread of brain tumors.
SCYNEXIS and Medicines for Malaria Venture (MMV) Sign HEOS® Agreement
The software is a comprehensive, web-based drug research information management system that supports geographically distributed scientists and facilitates collaboration.
Statistical Evaluation of Improvement in RNA Secondary Structure Prediction
With discovery of diverse roles for RNA, its centrality in cellular functions has become increasingly apparent. A number of algorithms have been developed to predict RNA secondary structure.
ATL and EnvironmentalReports Partner
Partnership aims to provide laboratories with the ability to manage all operational data and easily achieve regulatory compliance goals
Exemplar LIMS Accelerates Mitomics CLIA Certification and Serves as Foundation of Operations
Phase One of the project encompassed a large scope
BD Diagnostics Expands Portfolio with Automated Instrumentation Technologies
Company announced the expansion of its microbiology portfolio to include new automated instrumentation technologies that will enable the Company to offer innovative total lab automation solutions to hospitals and laboratories worldwide.
DNAnexus Announces Strategic Alliances to Drive the Advancement of DNA-Based Medicine
Teams with top healthcare organizations Geisinger Health System and UCSF.
Bring a Buddy to ELA 2012
Select Biosciences, organisers of the Second European Lab Automation (ELA) at the Congress Center Hamburg, Germany from 30th-31st May 2012, is pleased to offer a ‘bring a buddy’ discount on conference registration fees.
Professor Andrew Morris Appointed Scotland's Chief Scientist
Professor Morris is co-Director of the Medical Research Institute at the University of Dundee and an internationally renowned expert in diabetes and health informatics.
INTERPHEX Unveils Conference Programming For May 2012 Event
This year’s conference and technical sessions will mark a new level of content, including new session criteria and formats, growth in the number of senior-level speakers, and a third day of programming.
Recombinant Data Named Finalist in "Most Promising Company" Competition
Only software company to be nominated in the category at the Personalized Medicine World Conference 2012 (PMWC).
CLC bio and VIB Agree on an Academic Regional Site License
Companies announced the signing of the site license agreement for CLC bio's sequence analysis software CLC DNA Workbench.
Applied Proteomics Appoints CEO Following Series B Financing
Applied Proteomics Inc. announce the appointment of Peter Klemm, Ph.D., as chief executive officer after securing $22.5 million Series B financing.
Integromics Partners with FPGMX to Develop Low-Cost Methods for Clinical Genomics
Venture attracts EUR one million grant for ‘new frontier’ of data interpretation for medical usage.
Genomic Health Announces Formation of New Genetics Subsidiary
New venture to focus on integrating clinically relevant genetic information from the human genome into routine medical practice.
Company announced the expansion of its microbiology portfolio to include new automated instrumentation technologies that will enable the Company to offer innovative total lab automation solutions to hospitals and laboratories worldwide.
DNAnexus Announces Strategic Alliances to Drive the Advancement of DNA-Based Medicine
Teams with top healthcare organizations Geisinger Health System and UCSF.
Bring a Buddy to ELA 2012
Select Biosciences, organisers of the Second European Lab Automation (ELA) at the Congress Center Hamburg, Germany from 30th-31st May 2012, is pleased to offer a ‘bring a buddy’ discount on conference registration fees.
Professor Andrew Morris Appointed Scotland's Chief Scientist
Professor Morris is co-Director of the Medical Research Institute at the University of Dundee and an internationally renowned expert in diabetes and health informatics.
INTERPHEX Unveils Conference Programming For May 2012 Event
This year’s conference and technical sessions will mark a new level of content, including new session criteria and formats, growth in the number of senior-level speakers, and a third day of programming.
Recombinant Data Named Finalist in "Most Promising Company" Competition
Only software company to be nominated in the category at the Personalized Medicine World Conference 2012 (PMWC).
CLC bio and VIB Agree on an Academic Regional Site License
Companies announced the signing of the site license agreement for CLC bio's sequence analysis software CLC DNA Workbench.
Applied Proteomics Appoints CEO Following Series B Financing
Applied Proteomics Inc. announce the appointment of Peter Klemm, Ph.D., as chief executive officer after securing $22.5 million Series B financing.
Integromics Partners with FPGMX to Develop Low-Cost Methods for Clinical Genomics
Venture attracts EUR one million grant for ‘new frontier’ of data interpretation for medical usage.
Genomic Health Announces Formation of New Genetics Subsidiary
New venture to focus on integrating clinically relevant genetic information from the human genome into routine medical practice.
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GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Effective Use of In-Silico Tools in Lead Optimization
ACD Labs
Of all the challenges facing medicinal chemists in general, one of the most significant must be transforming an active molecule into a viable drug. Lead optimization efforts are guided by a combination of factors, such as potency, ease of synthesis, patentability concerns, specific synthetic constrains of the interaction with the target, as well as the lead’s toxicity and ADME properties.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants
ACD Labs
This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Understanding the Role of Quality by Design in Chromatographic Method Development
ACD Labs
Quality by Design (QbD) has become popular within the pharmaceutical industry and the FDA has cited a risk-based approach to drug development as a desirable state for the near future.1 In this state, more complete information and transparency relating to risk assessment will be made available for new drug aplications speeding the approval process, and preventing late-stage failures.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data
ACD Labs
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Effective Use of In-Silico Tools in Lead Optimization
ACD Labs
Of all the challenges facing medicinal chemists in general, one of the most significant must be transforming an active molecule into a viable drug. Lead optimization efforts are guided by a combination of factors, such as potency, ease of synthesis, patentability concerns, specific synthetic constrains of the interaction with the target, as well as the lead’s toxicity and ADME properties.
New Approach for In Silico Genotoxicity Testing of Impurities and Degradants
ACD Labs
This study presents a novel approach to aid this assessment based on probabilistic predictors of mutagenicity in Ames test and binding to Estrogen Receptor, supplemented by a knowledge-based system of structural alerts.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Understanding the Role of Quality by Design in Chromatographic Method Development
ACD Labs
Quality by Design (QbD) has become popular within the pharmaceutical industry and the FDA has cited a risk-based approach to drug development as a desirable state for the near future.1 In this state, more complete information and transparency relating to risk assessment will be made available for new drug aplications speeding the approval process, and preventing late-stage failures.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data
ACD Labs
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
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