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Webcasts
How to Optimize Sample Preparation Step Prior to Extraction
Discover the benefits of bead-binding for sample preparation in this on demand webinar from Bertin Technologies.
Managing Pharmaceutical Lab Data Management to Ensure Compliance
Join Stacey Brown and William Leonard, Senior Validation Analysts for Informatics at Thermo Fisher Scientific, to understand more about the complex requirements of pharmaceutical data management.

Market Reports
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
The Global Bioinformatics Market: Market size, forecasts and company profiles
Business Insights

This report provides analysis of bioinformatics market over three major segments, namely tools, content/database and service. It further analyzes each macro market with respect to sub segments from the market prospective. It also gives a qualitative and quantitative view of the bioinformatics market over major geographical regions.
Scientific News
Researchers Develop Software That Could Facilitate Drug Development
AptaTRACE can identify aptamers, potentially speed drug advancement.
Protein Nanocages Could Improve Drug Design and Delivery
HHMI scientists have designed and built 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
Connectome Map More Than Doubles Human Cortex’s Known Regions
Researchers at NIH have developed software that automatically detects the “fingerprint” of each of these areas in an individual’s brain scans.
Virus Inspired Cell Cargo Ships
Virus-inspired container design may lead to cell cargo ships following construction of ten large, two-component, icosahedral protein complexes.
Three-Drug Combinations Counter Antibiotic Resistance
Research shows that combinations of three different antibiotics can treat resistant bacteria, even if they are ineffective independently.
Supercomputing and Drug Discovery
New biotech company uses supercomputer simulations to speed up drug discovery and biotech molecule development.
Identifying Cancer Drug Targets Using 3D-Modelling
Researchers are now able to model genetic mutations manipulation of proteins that can potentially drive cancer.
Human Evolution Driven by Viruses
Study finds surprising percentage of protein adaptions in humans have been driven by viruses.
Earliest Sign of Alzheimer's Development Discovered
Researchers have identified the first physiological signs of late-onset Alzheimer's disease, underlining the importance of computational power in neurology.
Computational Method Offers Significant Boost in Finding New Cancer Targets
MIT and ARIAD Pharmaceuticals team have identified evidence of significant cancer mutations.
Business News
NIH Funds Precision Medicine
NIH have committed roughly $31M to launch a new program for Transdisciplinary Collaborative Centers for health disparities research.
PierianDX, ArcherDX Partner Up
ArcherDX and PierianDx collaboration allows for enhanced next-generation sequencing testing capabilities through pipeline integration.
NIH-Funded Center to Study Inefficiencies in Clinical Trials
Researchers at the Duke Clinical Research Institute (DCRI) and Vanderbilt University Medical Center (VUMC) have received a major federal grant to study how multisite clinical trials of new drugs and therapies in children and adults can be conducted more rapidly and efficiently.
Auspherix Appoints New Clinician to Scientific Advisory Board
Auspherix has announces that it has expanded its Scientific Advisory Board with the appointment of highly experienced clinician, Professor William Hope.
Accuray Receives FDA Clearance
Company has received FDA clearance for the Radixact™ image-guided radiation therapy platform and integrated software.
Agilent to Acquire iLab Solutions
Companies have announced they have signed a definitive agreement under which Agilent will acquire substantially all of the assets of iLab, the market leader in cloud-based solutions for core laboratory management.
Autoscribe Informatics Appoints Distributor for France, Italy & Switzerland
Autoscribe Informatics has appointed Ritme as its distributor for the Matrix Gemini Laboratory Information Management System (LIMS) in France, Italy and Switzerland. Ritme has been selling scientific software and offering software support since 1989, with the prime objective of helping its customers make the best use of their software solutions.
Helsinki Chemicals Forum Examines the Relationship of Chemicals to the Circular Economy
Forum addresses economic development and sustainability with a particular emphasis on the opportunities and challenges the circular economy poses for chemicals regulation.
LindaCare Releases OnePulse™ v1.0 and Rolls Out at UZ Leuven
OnePulse™ v1.0 has been released to improve tele-monitoring follow-up of patients suffering from chronic heart disease with CIED.
Qiagen Amends Terms to Exiqon Acquisition Offer Again
Acceptance rate lowered to 89.20% of share capital and voting rights to reflect possible effect of warrants.

Events
3rd Life Science Knowledge Man
08 Aug 2016
3rd Life Science Knowledge Man ...
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Featured Event
21 Aug 2016
Computer System Validation ...
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6th International Conference o
22 Aug 2016
6th International Conference o ...
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Featured Event
01 Sep 2016
THE DATA INTEGRITY 2016 – ASIA ...
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ePosters
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
1Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Toronto, ON. M5C 1B5. Canada; 2ACD/Labs, Moscow, Russia

A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis
Institute of high performance Computing, Astar

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
The Case for CASE: Computer-Assisted Structure Elucidation
ACD/Labs

Modern CASE systems such as Structure Elucidator Suite provide the necessary capability accurately elucidate a novel chemical structure for complex molecules based on readily available NMR data sets. This allows organizations to avoid expensive, labor-intensive, and time-consuming synthetic efforts.
A Unified Software Platform for Laboratory Informatics
Advanced Chemistry Development, Inc. (ACD/Labs), Toronto, Canada.

Reported here are capabilities in automated workflows involving analytical data with chemical structures. Specifically described is automated homogenization of data from a set of instruments, including NMR structure verification, as one solution.
Addressing False Positive Variants Arising from Pseudogenes
1National Heart and Lung Institute, Imperial College, London, UK, 2NIHR Cardiovascular BRU, Royal Brompton and Harefield NHS Trust, London, UK, 3Royal Brompton and Har

Clinical genetic testing has been transformed in recent years by the introduction of Next-Generation Sequencing (NGS).
PredRet: Prediction of Retention Time by Direct Mapping between Multiple Chromatographic Systems
Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all’Adige (TN), Italy.; Department of Stress and Developmental Biology, Leibniz Institute

Retention time (RT) information is under-utilized in LC-MS based metabolomics and sharing of RTs between systems is not currently possible. PredRet is a new system that allows highly accurate mapping and prediction of RTs between LC systems.
Building a digital pathology ecosystem for education and research
Department of Pathology, Faculty of Medicine, Vrije Universiteit Brussel; Department of Pathology, University Hospital Brussels

We wanted to build a core digital pathology infrastructure to support different use cases. Various images platforms needed to be accessible through a single access point, and support different user profiles. We wanted a scalable solution that would allow interaction between equipment from different research groups.
We built a centralized infrastructure that integrates a variety of imaging platforms, and now have an interconnected network of heterogeneous and scalable information silos.
Predicting Regioselectivityand Labilityof Cytochrome P450 Metabolism using Quantum Mechanical Simulations
Optibrium

Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism using Quantum Mechanical Simulations
The Power Decoder simulator for the evaluation of pooled shRNA screen performance
GE Healthcare Dharmacon, Inc.

Power Decoder (written in R and Python) simulates shRNA pooled screening experiments in silico to allow for the estimation of a screen’s statistical power. Populations of shRNAs were engineered in such a way that the magnitude of depletion and enrichment was known, then using the negative binomial distribution, an in silico model was developed to successfully resemble data from an actual laboratory experiment.
Knockdown of long noncoding RNAs in breast cancer
GE Healthcare Dharmacon, Inc.

RNAi global collaboration study using Lincode siRNA in a primary screen of tumor and nontumor breast cell lines. Hundreds of lncRNAs are found to affect viability and cell morphology of breast cancer. Presented at Keystone Symposia on Long Noncoding RNAs: From Evolution to Function, Mar 15 - Mar 20, 2015.
Application Notes
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation

Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation

This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific

Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies

The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation

As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
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