Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Thermo Fisher Scientific Updates Proteomics Analysis Software

Published: Wednesday, September 12, 2012
Last Updated: Wednesday, September 12, 2012
Bookmark and Share
Protein Metrics’ Byonic Search Software adds “ultimate search strategy” to Proteome Discoverer software version 2.0 to streamline post translational modification analysis.

Thermo Fisher Scientific Inc. introduced Thermo Scientific Proteome Discoverer software version 2.0 for analyzing qualitative and quantitative proteomics data. As part of the release, the company announced a non-exclusive agreement with Protein Metrics, Inc. to license the company’s Byonic™ database search software, adding next-generation capability to streamline analysis of glycopeptides and other post translational modification data.

The company is featuring Proteome Discoverer software and a range of other proteomics solutions within booth 707 during the HUPO 11th Annual World Congress in Boston from Sept. 9 - 13.
Thermo Fisher will also feature the Proteome Discoverer software at HUPO during a lunchtime workshop on the latest findings in glycomics and glycoproteomics. The workshop runs from 12:00 - 1:30 p.m. on Tuesday, Sept. 11.  Chris Becker, Protein Metrics CEO, will also discuss the software during a presentation at IMSC in Kyoto on September 19. The presentation,Automated Identification of Intact Glycopeptides from Complex Samples,is co-authored by scientists from Protein Metrics, Thermo Fisher and Institute of Biological Chemistry, Academia Sinica in Taipei, Taiwan.

“We call this the ‘product-dependent acquisition’ because users are able to acquire data from only the molecules of interest such as glycopeptides,” said Andreas Huhmer, marketing director, Thermo Fisher. “This greatly simplifies glycoprotein analysis and makes it accessible to a much wider range of scientists. Glycoproteomics workflows are no longer as complex as many people believe.”

“We are delighted to be working with Thermo Fisher to integrate our Byonic software into Proteome Discoverer software,” added Becker. ”As the capabilities of Thermo Fisher’s mass spectrometer systems reach new heights, it is important that the software keep pace to bring the most extensive and accurate information to users.”

Proteome Discoverer software version 2.0 combines spectral library searching with classical database searching for fast, highly reliable identification of true positive peptide spectrum matches. Huhmer calls this “the ultimate search strategy.” The software also includes a multi-threaded SEQUEST® search engine that takes advantage of the latest computer architecture to accelerate database searches. The software’s peptide and protein false discovery rate and probability (PFDRP) feature provides high-confidence identification of proteins and peptides. High-confidence measurement of phosphorylation sites is provided by PhosphoRS 2.0, included in Proteome Discoverer 2.0.

The new version of Proteome Discoverer software also generates reports automatically, saving users large amounts of time and effort. This is especially useful for large studies where hundreds of files are interpreted.

Proteome Discoverer software version 2.0 is compatible with all current Thermo Scientific Orbitrap-based LC/MS instruments. Planned shipping date is December 1, 2012.

Protein Metrics’ PreviewTM software is also now available through Thermo Fisher. Preview software samples MS/MS data to measure mass errors, digestion specificity and modifications for subsequent full protein database search.

In addition to Proteome Discoverer, Thermo Fisher is featuring a wide range of other qualitative and quantitative proteomics solutions within booth 707. These include:

•    The Thermo Scientific Q Exactive hybrid quadrupole Orbitrap® mass spectrometer, designed for confident identification, quantification and confirmation in a single run
•    Thermo Scientific SimGlycan software, designed to speed the characterization of complex glycans through automated interpretation of MS data
•    Thermo Scientific Mass Spectrometry Immunoaffinity pipette tips, which enhance protein detection and reduce sample preparation
•    Thermo Scientific NanoDrop UV-Vis Spectrophotometers, which facilitate concentration measurements of 2 mL protein samples without cuvettes, capillaries or dilution

SEQUEST® is a registered trademark of the University of Washington.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Fisher Scientific Signs Distribution Agreement with MKI
The agreement sees Thermo become the exclusive worldwide marketer and distributor of MKI’s Lipid Search software for interpretation of lipidomic research data.
Tuesday, July 09, 2013
Hong Kong Science and Technology Parks Corporation Provides SaaS LIMS to Startup Companies
HKSTPC uses SaaS LIMS to break the bounds of traditional laboratory information management systems (LIMS) and offer services on a time-share basis to support a variety of scientific data-centric operations from biotechnology to forensic to contract labs.
Friday, August 17, 2012
Evolution of SaaS LIMS Continues
Mobile technology is affecting SaaS LIMS functionality
Monday, July 09, 2012
Scientific News
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Biomedical Imaging at One-Thousandth the Cost
Mathematical modeling enables $100 depth sensor to approximate the measurements of a $100,000 piece of lab equipment.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
On Top of the Flu
Chance for advance warning in search-based tracking method.
TGAC Announces Milestone in Wheat Research
A more complete and accurate wheat genome assembly is being made available to researchers, by The Genome Analysis Centre (TGAC) on 12 November 2015.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Is Allergy the Price We Pay for Our Immunity to Parasites?
New findings help demonstrate the evolutionary basis for allergy.
Scroll Up
Scroll Down

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos