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Genedata Biologics 3.0 Boosts Efficiency Through Standardization

Published: Sunday, February 10, 2013
Last Updated: Saturday, February 09, 2013
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Enhanced, integrated biologics platform extends biopharma R&D support - from early library generation to candidate development

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, has announced the release of Genedata Biologics™ 3.0, the latest version of its enterprise solution for biologics R&D. A first-in-class software solution for integrated data management, Genedata Biologics enables R&D organizations to more efficiently discover and develop novel biotherapeutics. Version 3.0 dramatically improves process efficiency with new functionality for standardization of antibody screening, protein engineering, and protein production processes.

Standardization – The Strategic Advantage for Innovative R&D in Biotherapeutics

Workflow and nomenclature standardization are key success factors for large-scale biopharma discovery operations, which consist of specialized groups working in division-of-labor environments across departments and sites, as well as with numerous external partners and CROs. A scalable data management platform shared among all stakeholders and directly interfacing with laboratory automation equipment is required to facilitate the frequent handover and processing of candidate molecules, samples, and testing results.

“Standardization is a strategic advantage in today’s biopharma R&D. The new version of Genedata Biologics provides a complete view on all biologics candidates and their history,” said Dr. Othmar Pfannes, CEO of Genedata. “The standardization of these views and the underlying automated data processing minimizes duplication of work, eliminates error-prone manual activities, and provides extremely valuable transparency across an organization for efficient decision making. Our insight into standard processes and best practices has driven the development of Genedata Biologics, which is becoming the data management platform of choice for innovative biologics R&D organizations.”

Genedata Biologics V 3.0 – Highlights

Data Management & Access Control Framework: New user group infrastructure provides a fine-granular mechanism to control access to sensitive data in a collaborative environment. The system now supports cross-departmental and external data exchange with CROs and CMOs, as well as technology transfers among research partners, which is of vital importance in IP-critical environments.

Flexible Reporting Engine: New framework for generating customized reports for scientists, project managers, technicians, and management. Easily generated reports can now be tagged for keywords and relationship (e.g. reporting all cell lines stably expressing Fab-Fvs), research stage and success of results (e.g. portfolio of leads across different screening efforts), or grouped with data, e.g. Protein Expression Batches along with expression levels, vector information (i.e. signal peptides, promoters), or antibody germline sequence information (i.e. IGHV1-24). Typical examples also include KPIs (e.g. real-time overview of the number of candidates successfully expressed and purified, with a monthly break-down), and dashboards for facilitating decision support.

Extended Molecule Processing Support: Enhanced functionalities to register, process, and visualize specific molecule types such as scFv and other antibody- and non-antibody molecules.
High-throughput Antibody Reformatting: Extended support of bulk reformatting from Fab-to-IgG and similar workflows; new reporting and statistics of recovered versus unrecovered clones using a parental Hit List, which enables straightforward antibody clone recovery; systematic handling of incomplete sequences; fully integrated re-streaking support.

Bulk Processing of Protein Production Samples: Support of fully automated protein expression and purification equipment and processes (e.g. automated transient transfection robots in 24-tube racks). Bulk create and edit from native Excel files, in addition to file-based uploads; protein purification batches, as well as assays and analytics data for expression constructs, cell lines, protein expression batches.

Extended Antigen Management: In-house produced antigens and externally-sourced antigen materials; different types of antigens (including cell lines, recombinant versions); integrated material management and availability tracking.

Dedicated Handling of Externally-sourced Materials: Processing and registration logic for externally sourced antibody molecules (e.g. reference compounds) or protein tools. Specific logic for registration and processing of incomplete information (e.g. lack of sequence information).

Expansion of Admin UIs: Facilitates data and configuration maintenance tasks enabling application administrators to easily introduce new controlled vocabularies, sequence motifs for automatic sequence annotations, among others.

Name Generator API: Construct a molecule or sample name by customer-defined rules such as applicable molecules, samples, or for other entities (e.g. for plate name generation). Additional APIs for external registration of actual product protein and protein purification batches for registration in corporate compound registration systems, and others.

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