Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Researchers Pair Experiments with Computer Models to Peer into Cells

Published: Wednesday, March 20, 2013
Last Updated: Wednesday, March 20, 2013
Bookmark and Share
BBSRC-funded researchers have developed a new strategy that can give scientists a better insight into how complex molecular machineries function in living cells.

In research published in the journal Molecular Systems Biology, the team from the University of Warwick, Manchester Interdisciplinary Biocentre and Liverpool University showed how to extract in vivo information about how complex molecular systems in yeast cells are controlled.

By making small changes in a process called mRNA translation, a crucial step in the manufacture of proteins within a cell, the team was able to obtain important information without disrupting the system.

These data were used to set parameters for a detailed computational model of protein synthesis in cells, revealing a number of insights about the process which were previously unknown.

For example, the research showed how individual components in the mRNA translation process had co-evolved to share responsibility for controlling how fast proteins are made.

Professor John McCarthy, professor of molecular systems biology at Warwick University, said: "A major objective of systems biology is to move forward from analysis of individual cellular components to create accurate digital models that provide insight into how these components work together within living cells.

"Through this approach, we ultimately hope to understand the 'emergent properties' of molecular systems in cells that, for decades, have fascinated biologists but evaded proper explanation.

"Up to now, it has proved very difficult to obtain an accurate picture of how cells control the various processes that go on inside them, leaving us largely guessing how the properties of individual components relate to the behaviour of systems that are assembled from them within living cells.

"Using minimal perturbations of precisely targeted steps of specific cellular processes together with a large number of quantitative analytical measurements, we have now made a major first step towards obtaining detailed insight into how the living cell's protein synthesis machinery is managed at the system level."

The approach has potential as a platform for a wide range of future studies into the molecular systems biology of gene expression.

The researchers also believe the combined experimental and computational approach taken should be applicable to multiple processes in a range of organisms.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Researchers Use ‘Big Data’ Approach to Map the Relationships Between Human and Animal Diseases
EID2 database used to prevent and tackle disease outbreaks around the globe.
Thursday, July 17, 2014
BBSRC Shows UK Commitment to European Bioinformatics Agreement
BBSRC has signed an agreement that will enable maximum impact of Europe's bioscience research data.
Monday, September 09, 2013
Minister Announces UK Funding to Build World-First Synthetic Yeast
UK scientists to build a chromosome for the world's first synthetic yeast.
Friday, July 12, 2013
BBSRC Invests in Future of Livestock Genomics
Over £1.1M of new investment has been awarded for ARK-Genomics, with a focus on the genetics and genomics of livestock species.
Monday, January 07, 2013
UK Bioscience Sparkles with New Diamond Fellowship
UK bioscience has received a major boost following the announcement of 16 new fellowships by the Biotechnology and Biological Sciences Research Council (BBSRC) including the first ever Diamond Fellowship, so named because the post will be based at the new Research Complex at Harwell, adjacent to the Diamond Light Source in Oxfordshire - the UK national synchrotron facility.
Tuesday, July 21, 2009
Scientific News
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Biomedical Imaging at One-Thousandth the Cost
Mathematical modeling enables $100 depth sensor to approximate the measurements of a $100,000 piece of lab equipment.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
On Top of the Flu
Chance for advance warning in search-based tracking method.
TGAC Announces Milestone in Wheat Research
A more complete and accurate wheat genome assembly is being made available to researchers, by The Genome Analysis Centre (TGAC) on 12 November 2015.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Is Allergy the Price We Pay for Our Immunity to Parasites?
New findings help demonstrate the evolutionary basis for allergy.
Scroll Up
Scroll Down

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos