Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Waters Introduces the SYNAPT G2-Si to its Mass Spectrometer Product Line

Published: Tuesday, June 11, 2013
Last Updated: Tuesday, June 11, 2013
Bookmark and Share
Instrument is the most advanced ion mobility-enhanced research mass spectrometer.

Waters Corporation has unveiled the new Waters® SYNAPT® G2-Si Mass Spectrometer at the 61st conference of the American Society of Mass Spectrometry (ASMS).

The company is also previewing its UNIFI® CCS Research Edition and the new TransOmics Version 2.0 informatics products for the new SYNAPT G2-Si mass spectrometer and demonstrating their benefits for a variety of small molecule applications and cutting-edge Omics-focused research.

The SYNAPT G2-Si System integrates a third dimension of resolution and separation power into a new suite of untargeted and targeted LC/MS/MS workflows.

This powerful new tool gives researchers a means with which to gain a deeper understanding of molecular biology and disease mechanisms, to develop the next generation of healthcare treatments or chemical materials, or to screen food products or environmental samples for contaminants.

The SYNAPT G2-Si mass spectrometer now combines the unique power of Travelling Wave (T-Wave) Ion Mobility Separations with new data acquisition and informatics technologies, and collision cross section (CCS) measurements to bring to the toughest analytical applications, unparalleled information and confidence at a level not possible by mass and chromatographic separation alone.

The SYNAPT G2-Si mass spectrometer is the first MS system to elevate CCS alongside retention time and mass to charge ratio (m/z) as a robust, reliable identification parameter in library-based screening.

“CCS measurements have the potential to transform the way people screen for known compounds, because unlike parameters like retention time, CCS values are unaffected by different matrices and chromatographic methods, and give you a much higher level of confidence that you found what you’re looking for,” said Dr. Severine Goscinny, Belgium Scientific Institute for Public Health, Brussels, Belgium.

Dr. Goscinny continued, “The SYNAPT G2-Si system exemplifies Waters continuing commitment to innovation in mass spectrometry and collaborating with researchers on their journey of exploration.”

The collision cross section of a molecule is an important distinguishing feature that is directly related to its chemical structure and three-dimensional conformation in the gas-phase.

Like molecular mass, this additional orthogonal property of a molecule (through the use of high-efficiency T-wave ion mobility technology) gives scientists increased coverage and clarity for profiling mixtures or gaining additional measurements with which they can investigate chemical structures or better confirm a molecule’s identity.

Integrating separation by CCS into targeted and untargeted experiments through new high-definition data-directed-analysis (HD-DDA) and high definition multiple reaction monitoring (HD-MRM) modes brings compelling benefits to the most challenging qualitative and quantitative applications.

• Maximized time-of-flight (Tof) duty cycle and effective sensitivity - of up to 10x in MS/MS mode - for targeted discovery and quantitation
• Improved LC/MS/MS efficiency with a 40% improvement in the numbers of proteins identified from an E. coli sample and the identification of more than 2,000 proteins from a HeLa sample
• Routine ultra-sensitive MS/MS assays with the benefit of high resolution and accurate mass for targeted quantification experiments
• Physical separation of interferences away from the molecule or transition of interest on the basis of their collision cross section for improved selectivity when working with very complex matrices.
• A new and faster 2.5KHz solid state laser combined with new software for improved spatial resolution (down to 15µm) for cleaner mass spectral data and greater image throughput when performing experiments with MALDI imaging and T-wave ion mobility

As evidence of the successful use of T-Wave ion mobility mass spectrometry for the research laboratory, the International Journal of Ion Mobility Spectrometry in February of this year published an exclusive, two-volume special edition series on T-Wave ion mobility featuring 13 scientific articles by some of the world’s top scientists.

As the newest member of the SYNAPT family of mass spectrometers, the SYNAPT G2-Si system can separate individual isomers, conformers, and isobaric compounds; help determine sites of biotransformation; study structure at physiological concentrations; comprehensively profile complex mixtures and minimize false positives and negatives in screening experiments.

For more information:

Waters Enhances its Omics Research Platform Solution with TransOmics 2.0 Informatics

At ASMS Waters is previewing an enhanced range of Omics Research Platform Solutions, powered by TransOmics™ 2.0 Informatics.

The new TransOmics 2.0 informatics packages for proteomics and metabolomics/lipidomics, created exclusively for Waters by its strategic business partner Nonlinear Dynamics (Newcastle upon Tyne, UK), are based on extended versions of the Nonlinear Dynamics Progenesis™ LC-MS and CoMet products.

The TransOmics 2.0 informatics packages are specifically designed to process and visualize SYNAPT High Definition Mass Spectrometry (HDMS) Omics data, denominated with Collision Cross Section (CCS), from the new Waters SYNAPT G2-Si HDMS mass spectrometer.

Proteomics, metabolomics and lipidomics researchers routinely acquire large, content-rich, data sets that need to be efficiently reduced and intuitively visualized to facilitate the extraction of biologically significant results.

TransOmics 2.0 has been developed specifically to address these issues and reveal the potential of CCS denominated Omics data.

University of Washington Researcher, Matthew F. Bush, to Receive ASMS Research Award Sponsored by Waters Corporation

On Tuesday, June 11, Dr. Matthew Bush of the University of Washington will receive the 2013 ASMS Research Award sponsored by Waters Corporation in recognition of his research on intact protein complexes using mass spectrometry.

The award, which comes with a cash prize of $35,000, is being awarded to Dr. Bush for his laboratory’s research into developing and applying fast and sensitive mass spectrometry techniques for characterizing biological assemblies. This is the 27th year of award sponsorship by Waters Corporation.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Solutions to Old Challenges
Waters Corporation introduces a new NuGenesis Lab Management System (LMS) that integrates sample management functions and business operations across the enterprise. Technology Networks' Editor Helen Gillespie interviewed Waters' Garrett Mullen for details.
Tuesday, July 01, 2014
Waters, Omics LLC Partner to Advance Petroleum Sample Analysis
Collaboration Combines the Value of Ion Mobility Mass Spectrometry (IM-MS) and Accurate Mass Information with Petroleomics Data Processing.
Monday, June 16, 2014
Waters Acquires Nonlinear Dynamics
Nonlinear Dynamics is best known for their Progenesis software which offers researchers unique ways to analyze and visualize the raw proteomic data.
Thursday, August 08, 2013
Waters and DANI Instruments Announce Integrated and Compatible Network
Waters Empower Software Now Works Seamlessly with DANI Headspace and GC Instruments
Saturday, April 06, 2013
Waters Empower 3 Goes Mobile with New Laboratory Analytics Capabilities
New Empower release features tablet and smartphone accessibility and built-in analytics for critical system usage information.
Tuesday, March 19, 2013
Waters and DANI Instruments Announce Integrated and Compatible Network
Waters Empower Software now works seamlessly with DANI Headspace and GC Instruments.
Tuesday, March 19, 2013
Waters and Nonlinear Dynamics to Co-Develop Next Generation Research Solutions
Firms to combine complimentary expertise in analytical science and informatics to advance proteomics and metabolomics research.
Friday, August 03, 2012
Scientific News
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Biomedical Imaging at One-Thousandth the Cost
Mathematical modeling enables $100 depth sensor to approximate the measurements of a $100,000 piece of lab equipment.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
On Top of the Flu
Chance for advance warning in search-based tracking method.
TGAC Announces Milestone in Wheat Research
A more complete and accurate wheat genome assembly is being made available to researchers, by The Genome Analysis Centre (TGAC) on 12 November 2015.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Is Allergy the Price We Pay for Our Immunity to Parasites?
New findings help demonstrate the evolutionary basis for allergy.
Scroll Up
Scroll Down

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos