" "
Satellite Banner
Informatics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Genetic Mutation Helps Explain Development of Eczema

Published: Monday, November 04, 2013
Last Updated: Monday, November 04, 2013
Bookmark and Share
Researchers found that a mutation in the gene Matt/Tmem79 led to the development of spontaneous dermatitis in mice.

Scientists collaborating on an international research project led by Trinity College Dublin and the University of Dundee have identified a new genetic mutation linked to the development of a type of eczema known as atopic dermatitis (AD).

The gene, Matt/Tmem79, is involved in producing a protein, now called ‘mattrin’. However, protein expression was defective in individuals with the mutant gene, and this led to skin problems. In humans, mattrin is expressed within the cells that produce and maintain the skin’s function as a barrier. 

After identifying the relationship between the mutation and AD, the scientists looked for a similar pattern in people. They screened large cohorts of patients that suffered from AD, comparing them with unaffected control patients, and found that the equivalent human gene MATT/TMEM79 was similarly associated. The results of this study are published in the November issue of the leading peer-reviewed journal in allergy research, The Journal of Allergy and Clinical Immunology.

Professor Padraic Fallon, Chair of Translational Immunology in the School of Medicine at Trinity, who led the project, said:  “We have identified a new gene mutation that leads to atopic dermatitis (AD) in mice, and have taken that work further to demonstrate that a variant of the human gene is associated with AD in patients.”

Professor Fallon added: “This study highlights the value of research in which genetic patterns in animals provide a starting point to investigating human disease. This strategy enables us to identify new genes that are relevant in human disease and then examine the function of these genes during inflammation. This approach will ultimately help us to understand the factors leading to inflammatory diseases and assist in the development of new therapeutic strategies.”

Professor Irwin McLean, Scientific Director of the Centre for Dermatology and Genetic Medicine at the University of Dundee, jointly led the research that involved collaboration between scientists in Ireland, the United Kingdom, USA, Germany and Singapore. The work was funded by grants from the Wellcome Trust, Science Foundation Ireland and the National Children’s Research Centre.

Professor McLean added: “This study shows that disruption of the barrier function of the skin is a key driving force in the development of eczema.  Without an intact skin barrier, foreign substances can enter the body and trigger inflammation and allergy.”

AD is the most commonly diagnosed skin condition, affecting up to 20% of children. As well as having a genetic basis, the condition can also be triggered by environmental factors, such as pet fur, pollen and house dustmites. Dairy products, eggs, nuts and wheat have also been linked to the condition.

The article can be accessed online using the link below. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Cloud Computing System that can Reduce Carbon Emissions
The ‘Stratus’ system shares server load to meet green and cost-related goals of companies.
Wednesday, January 15, 2014
Scientific News
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
‘Lifespan Machine’ Probes Cause of Aging
Findings suggest that aging has no single mechanism.
Machine Learning Uncovers Unknown Bacterial Features
Technique robustly identified characteristic gene expression patterns in response to antibiotics, low oxygen conditions.
Nucleic Acid Computing Inside Cells
Using strands of nucleic acid, scientists have demonstrated basic computing operations inside a living mammalian cell.
Risk Map for Nematode Parasite in Uganda
Infection with the nematode parasite Mansonella perstans is one of the most neglected of the neglected tropical diseases.
DNA Analysis in the Fast Lane
Rice bioengineers' method should lead to better database of thermal behaviors.
Mapping out Cell Conversion
Researchers develop algorithm that takes the field of cell reprogramming forward.
Parallel Single-Cell Profiling
New single-cell genomics protocol allows researchers to study links between DNA modifications (methylation) and the activity of a gene.
ASCB: A CELLebration of Cell Biology
The last major congress of the year, ASCB is less a platform for launching new products, but one for confirming and consolidating the trends that have emerged over the past 12 months.
Three Glaucoma-Related Genes Discovered
NIH-funded genetics analysis of glaucoma is largest to date.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!