Optibrium™, today announced the release of a new version of its StarDrop™ software
platform. The latest release introduces MPO Explorer™, which provides
innovative new methods to guide ‘strategic’ decisions in research programmes,
by helping to identify the key properties and selection criteria with which to
select compounds with a high chance of success. The new module, alongside data
visualisation enhancements, further extends StarDrop’s capabilities to reduce
the time and cost to deliver high quality drug candidates.
MPO Explorer introduces unique (patent pending) methods that
guide the development and validation of multi-parameter scoring profiles,
tailored to a discovery project’s specific objectives. The resulting scoring
profiles can be applied with StarDrop’s Probabilistic Scoring approach for multi-parameter
optimisation (MPO), to effectively target novel compounds with a high chance of
success. The most important property criteria are also highlighted, focussing
experimental resources to generate the key data with which to identify
successful compounds. To promote objective decision making, the new module also
tests if a specific property criteria in a scoring profile may be artificially
distorting the selection of compounds to pursue. If a small change in a
criterion would lead to a different decision, this can highlight new avenues
for exploration and avoid missed opportunities.
These new capabilities are supported by further enhancements
to the core StarDrop application, including new data visualisation features
such as 3D scatter and chemical space plots.
In addition, StarDrop’s R-group analysis tool has been extended to
perform matched pair analysis, providing insight into the key substitutions in
a chemical series that have a significant impact on a compound’s properties.
Dr Matthew Segall, Optibrium’s CEO, commented: “StarDrop now
offers our users a comprehensive desktop environment to guide strategic
decisions in their drug discovery projects, optimise the use of resources and
intuitively target compounds with an improved chance of success. The latest
release delivers new technologies that represent the culmination of years of
leading edge research and further our goals to improve the efficiency and
productivity of our customers’ discovery projects.”