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Essential Bioinformatics
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Author: Jin Xiong ISBN: 0521600820 Paperback: 352 pages Publisher: Cambridge University Press; 1 edition (March 13, 2006) Language: English Essential Bioinformatics is a concise yet comprehensive textbook of bioinformatics, which provides a broad introduction to the entire field. Written specifically for a life science audience, the basics of bioinformatics are explained, followed by discussions of the state-of-the-art computational tools available to solve biological research problems. All key areas of bioinformatics are covered including biological databases, sequence alignment, genes and promoter prediction, molecular phylogenetics, structural bioinformatics, genomics and proteomics. The book emphasizes how computational methods work and compares the strengths and weaknesses of different methods. This balanced yet easily accessible text will be invaluable to students who do not have sophisticated computational backgrounds. Table of Content Preface; Part I. Introduction and Biological Databases: 1. Introduction; 2. Introduction to biological databases; Part II. Sequence Alignment: 3. Pairwise sequence alignment; 4. Database similarity search; 5. Multiple sequence alignment; 6. Profiles and hidden Markov models; 7. Protein motifs and patterns; Part III. Gene and Promoter Prediction: 8. Gene prediction; 9. Promoter and regulatory element prediction; Part IV. Molecular Phylogenetics: 10. Phylogenetics basics; 11. Phylogenetic tree construction methods and programs; Part V. Protein Structure Basics: 12. Protein structure basics; 13. Protein structure visualization, comparison and classification; 14. Protein secondary structure prediction; 15. Protein tertiary structure prediction; 16. RNA structure prediction; Part VI. Genomics and Proteomics: 17. Genome mapping, assembly and comparison; 18. Functional genomics; 19. Proteomics; Practical exercises; Glossary



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