Corporate Banner
Satellite Banner
Informatics
Scientific Community
 
Become a Member | Sign in
Home>Videos>This Video
  Videos

Return

In Silico Predictive Toxicology: Where are we at and Where are we Going?
Liverpool John Moores University

John Dearden, Emeritus Professor of Medicinal Chemistry Liverpool John Moores University

Abstract
In silico predictions of the toxicity of chemicals have the advantages of speed and cost, but accuracy needs to be improved. This is due, at least in part, to a shortage of good toxicity data on which to base in silico models. Much commercial software, and some free software, is now available for the prediction of numerous toxicity endpoints, and the performance of some of this software will be discussed. Attention is now focussing on mechanistic and toxicokinetic approaches, and on newer statistical methods, that will aid in silico prediction of toxicity. A recent book from our laboratory, edited by Mark Cronin and Judith Madden (In Silico Toxicology: Principles and Applications, RSC Publishing, 2010), brings all of this together, and more. The presentation will look in depth at two important endpoints, namely the human health endpoint skin sensitisation, and environmental toxicity as indicated by toxicity to the aquatic ciliate Tetrahymena pyriformis.

Request more information
Company product page

Scientific News
New Database for Sharing MS Clinical Trial Data
A new database containing nearly 2500 patient records from the placebo arms of nine multiple sclerosis (MS) clinical trials is now available for research by qualified investigators.
‘Precision Prevention’ for Colorectal Cancer
New risk prediction model — not yet ready for clinical use — incorporates genetic, lifestyle and environmental risk factors.
Characterizing Cancerous Genomic Variations
Tested on large tumor genomics database, REVEALER method allows researchers to connect genomics to cell function.
Uncovering Hidden Genomic Alterations that Drive Cancers
Tested on large tumor genomics database, REVEALER method allows researchers to connect genomics to cell function.
Spotting DNA Repair Genes Gone Awry
Ludwig researchers develop a two-pronged approach for identifying genes responsible for fixing DNA damage that can trigger cancer when compromised.
Interpreting “Dark Matter” DNA
Scientists at the Gladstone Institutes have invented a new way to read and interpret the human genome.
A Programming Language for Living Cells
New language lets researchers design novel biological circuits.
The Epigenetics of Childhood Cancer
Qlucore software enables researchers to more easily study the genetic influences behind childhood cancer.
Mining Whole Exome Data to Improve Cancer Therapies
New tool interprets the raw data of whole exome tumor sequencing and then matches the cancer’s unique genetics to FDA-approved targeted treatments.
Pittcon 2016: Accelerating Innovation And Enhancing Productivity With Technology
Collaboration and externalization of data highlight evolving lab operations.
Scroll Up
Scroll Down
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!