 |  |  |
|
|
 | BPM Technology as a Mechanism for Improvement of Automation Level in Life Sciences Silke Holzmüller-Laue, University of Rostock, speaking at European Lab Automation 2012 |
 | Current Challenges in Fragment-Based Drug Discovery Roderick E Hubbard, University of York, speaking at Discovery Chemistry Congress 2012. |
Biostorage Trends 2010
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on biological sample storage carried out in July 2010. The objectives of the study were to comprehensively document current practices and preferences in biological sample storage and to understand future user requirements.
Back to the Lab! Improving R&D Productivity and Efficiency with LIMS and ELNs
Datamonitor plc
The rigorous R&D processes of pharma and biotech have provided them with a wealth of data, documents and knowledge, but this information is often held in organizational silos, paper laboratory notebooks and disparate IT systems, rendering them virtually useless. Therefore, life sciences companies are implementing LIMS and ELNs to remove the silos and connect R&D groups across the enterprise.
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on biological sample storage carried out in July 2010. The objectives of the study were to comprehensively document current practices and preferences in biological sample storage and to understand future user requirements.
Back to the Lab! Improving R&D Productivity and Efficiency with LIMS and ELNs
Datamonitor plc
The rigorous R&D processes of pharma and biotech have provided them with a wealth of data, documents and knowledge, but this information is often held in organizational silos, paper laboratory notebooks and disparate IT systems, rendering them virtually useless. Therefore, life sciences companies are implementing LIMS and ELNs to remove the silos and connect R&D groups across the enterprise.
New Software Spots, Isolates Cyber-attacks to Protect Networked Control Systems
Software algorithm detects and isolates cyber-attacks on networked control systems that are becoming increasingly important to national infrastructure
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Tissue of Origin Determines Cancer-associated CpG Island Promoter Hypermethylation Patterns
Meehan, Sproul and co-workers conclude that general aberrant promoter hypermethylation in cancer does not promote tumorigenesis, but instead reinforces transcription repression inherited from pre-cancerous tissue.
Non-Genotoxic Carcinogen Exposure Induces Defined Changes in the 5-Hydroxymethylome
In a genome wide study Meehan, Moggs and MARCAR co-authors examined 5mC and 5hmC profiles of liver in control and phenobarbital treated mice. They observe dynamic and reciprocal changes in the 5mC/5hmC patterns over genes promoters that are transcriptionally up-regulated.
Are Laboratories Ready for Truly Mobile Working?
Ok so we all follow the newspapers, blog sites and various other "social feeds" (as they are known), but have you ever thought if our research laboratories are ready to embrace a new way of working?
SIGLa: An Adaptable LIMS for Multiple Laboratories
SIGLa has been developed with the aim of contributing to complex data management in the laboratory by managing large amounts of data and guaranteeing its consistency.
Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug Design
The group of scientists performed structural analyses on biologically important molecules and their complexes with partners, hoping to contribute to molecular design for controlling biologically abnormal functions.
Thermo Scientific Launches European Seminar Series: “New Frontiers in Water Analysis”
Seminars will feature new Thermo Scientific water analysis products and solutions.
SRI Speeds Development of Genome-Scale Models of Metabolic Networks
The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
Software algorithm detects and isolates cyber-attacks on networked control systems that are becoming increasingly important to national infrastructure
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Tissue of Origin Determines Cancer-associated CpG Island Promoter Hypermethylation Patterns
Meehan, Sproul and co-workers conclude that general aberrant promoter hypermethylation in cancer does not promote tumorigenesis, but instead reinforces transcription repression inherited from pre-cancerous tissue.
Non-Genotoxic Carcinogen Exposure Induces Defined Changes in the 5-Hydroxymethylome
In a genome wide study Meehan, Moggs and MARCAR co-authors examined 5mC and 5hmC profiles of liver in control and phenobarbital treated mice. They observe dynamic and reciprocal changes in the 5mC/5hmC patterns over genes promoters that are transcriptionally up-regulated.
Are Laboratories Ready for Truly Mobile Working?
Ok so we all follow the newspapers, blog sites and various other "social feeds" (as they are known), but have you ever thought if our research laboratories are ready to embrace a new way of working?
SIGLa: An Adaptable LIMS for Multiple Laboratories
SIGLa has been developed with the aim of contributing to complex data management in the laboratory by managing large amounts of data and guaranteeing its consistency.
Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug Design
The group of scientists performed structural analyses on biologically important molecules and their complexes with partners, hoping to contribute to molecular design for controlling biologically abnormal functions.
Thermo Scientific Launches European Seminar Series: “New Frontiers in Water Analysis”
Seminars will feature new Thermo Scientific water analysis products and solutions.
SRI Speeds Development of Genome-Scale Models of Metabolic Networks
The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
The Evolving Relationship of LIMS and Mobile Devices
An Interview with Abbott's Clive Baron about the new STARLIMS Version 11 and how it will leverage mobile devices.
India Laboratory Information Management System Market Trends 2013
Researchmoz releases report on LIMS market segment status in India
Personalis Selects Clarity LIMS, Citing Quick Deployment as Driver
Clarity LIMS User Base Growing
American Engineering Testing Inc. Implements QESTLab, QESTField and Construction Hive
LIMS implementation expected to improve the efficiency and quality of AET operations by electronically registering samples and entering data in the field.
Bruker and SCiLS GmbH Announce an Exclusive Partnership for SCiLS Lab Software for MALDI Imaging
SCiLS Lab is the software developed by SCiLS GmbH which allows the user-friendly statistical analysis of large MALDI imaging datasets
Promium Awarded National LIMS Contract from Environment Canada
Environment Canada to implement Element LIMS for national network of environmental laboratories.
Core Informatics and OpenEye Scientific Software Forge Partnership
New partnership integrates OpenEye cheminformatics software into Core Informatics' web-based LIMS and ELN
RURO Releases White Paper on Creating the Modern Laboratory with LIMS 24/7
White paper outlines key challenges faced by laboratory managers
Mount Sinai Selects Exemplar LIMS for Genomics Core Facility
Exemplar LIMS utilized for Mount Sinai CLIA-certified Genomics Core Facility employing diverse NGS platforms
Analytik Jena Establishes Subsidiary in Thailand
New company to bolster Analytik Jena’s activities in the Southeast Asian market.
An Interview with Abbott's Clive Baron about the new STARLIMS Version 11 and how it will leverage mobile devices.
India Laboratory Information Management System Market Trends 2013
Researchmoz releases report on LIMS market segment status in India
Personalis Selects Clarity LIMS, Citing Quick Deployment as Driver
Clarity LIMS User Base Growing
American Engineering Testing Inc. Implements QESTLab, QESTField and Construction Hive
LIMS implementation expected to improve the efficiency and quality of AET operations by electronically registering samples and entering data in the field.
Bruker and SCiLS GmbH Announce an Exclusive Partnership for SCiLS Lab Software for MALDI Imaging
SCiLS Lab is the software developed by SCiLS GmbH which allows the user-friendly statistical analysis of large MALDI imaging datasets
Promium Awarded National LIMS Contract from Environment Canada
Environment Canada to implement Element LIMS for national network of environmental laboratories.
Core Informatics and OpenEye Scientific Software Forge Partnership
New partnership integrates OpenEye cheminformatics software into Core Informatics' web-based LIMS and ELN
RURO Releases White Paper on Creating the Modern Laboratory with LIMS 24/7
White paper outlines key challenges faced by laboratory managers
Mount Sinai Selects Exemplar LIMS for Genomics Core Facility
Exemplar LIMS utilized for Mount Sinai CLIA-certified Genomics Core Facility employing diverse NGS platforms
Analytik Jena Establishes Subsidiary in Thailand
New company to bolster Analytik Jena’s activities in the Southeast Asian market.
 | ||||||||||||||||
|
Processing and Managing Analytical Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
An Integrated Solution for Automated Nanoliter Hit-Picking at BioFocus
1TTP Labtech Ltd 2BioFocus
This poster describes a section of BioFocus’s screening workfolow where mosquito X1 is integrated with a RapidStak plate stacker (Thermo Scientific) using TTP LabTech’s CherryPicker software. This allows the mosquito X1 to work unattended for extended periods. The CherryPicker software drives the system automatically by converting pick lists provided by BioFocus’ LIMS system into mosquito protocols, and feeding appropriate plates via the RapidStak.
Rapid Scale-up of Exome Sequencing Research using a Commercial Lab and Data Management Solution
Genologics
In mid-2009 The Nickerson Lab in the Department of Genome Sciences at the University of Washington faced the daunting task of rapidly scaling up their next generation sequencing laboratory. Given the enormous amount of data to be generated, a critical part of this scale-up was picking the right LIMS solution. This system needed to handle data flow from sample submission to results reporting.
Protein array-based screening of autoantibody signatures
Fondazione Istituto Nazionale Genetica Molecolare
The evidence for an association between autoimmune diseases and chronic HCV infection has been clearly established. To this aim, a protein array was employed to analyze serum samples of HCV patients w/wo autoimmune complications, of patients with autoimmune hepatitis but not infected with HCV and of healthy donors as controls. A panel of autoantigens able to discriminate among the three groups of patients was identified for potential use as biomarkers.
Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
Indian Institute of Toxicology Research
The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.
Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
Indian Institute of Toxicology Research
The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.
Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Rajalakshmi Engineering college
Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.
Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Rajalakshmi Engineering college
Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.
qPCRas a primary screen in drug discovery
MRC -CPE
We report the use of qPCR technique to follow the thermal unfolding of proteins by the binding of the dye SYPRO Orange, and exploit its potential as a robust and high-throughput primary screen for small molecule drug discovery.
DOCKING STUDIES OF A NEW HETEROCYCLIC METHYLTHIOMORPHOLIN PHENOLS DERIVATIVES AS ANTIHYPERTENSIVE DRUGS WITH ACE TARGET.CASE FESCDIPINE II
1.Departamento de C. Químicas FESC, UNAM, 2.Facultad de C. Química UNACH, 3. Facultad de Química, UAEM, 4.Facultad de Medicina UNAM
As part of the Drug Design in Medicinal Chemistry Program of the UNAM, new methylthiomorpholinphenol compounds with cardiovascular effect, were studied. One of them, FESCDIPINE II, was an excellent antihypertensive drug, that has low toxicity and preliminary studies indicate that the Angiotensin-converting enzyme (ACE) system is the biological target of this compound.
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
An Integrated Solution for Automated Nanoliter Hit-Picking at BioFocus
1TTP Labtech Ltd 2BioFocus
This poster describes a section of BioFocus’s screening workfolow where mosquito X1 is integrated with a RapidStak plate stacker (Thermo Scientific) using TTP LabTech’s CherryPicker software. This allows the mosquito X1 to work unattended for extended periods. The CherryPicker software drives the system automatically by converting pick lists provided by BioFocus’ LIMS system into mosquito protocols, and feeding appropriate plates via the RapidStak.
Rapid Scale-up of Exome Sequencing Research using a Commercial Lab and Data Management Solution
Genologics
In mid-2009 The Nickerson Lab in the Department of Genome Sciences at the University of Washington faced the daunting task of rapidly scaling up their next generation sequencing laboratory. Given the enormous amount of data to be generated, a critical part of this scale-up was picking the right LIMS solution. This system needed to handle data flow from sample submission to results reporting.
Protein array-based screening of autoantibody signatures
Fondazione Istituto Nazionale Genetica Molecolare
The evidence for an association between autoimmune diseases and chronic HCV infection has been clearly established. To this aim, a protein array was employed to analyze serum samples of HCV patients w/wo autoimmune complications, of patients with autoimmune hepatitis but not infected with HCV and of healthy donors as controls. A panel of autoantigens able to discriminate among the three groups of patients was identified for potential use as biomarkers.
Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
Indian Institute of Toxicology Research
The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.
Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
Indian Institute of Toxicology Research
The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.
Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Rajalakshmi Engineering college
Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.
Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Rajalakshmi Engineering college
Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.
qPCRas a primary screen in drug discovery
MRC -CPE
We report the use of qPCR technique to follow the thermal unfolding of proteins by the binding of the dye SYPRO Orange, and exploit its potential as a robust and high-throughput primary screen for small molecule drug discovery.
DOCKING STUDIES OF A NEW HETEROCYCLIC METHYLTHIOMORPHOLIN PHENOLS DERIVATIVES AS ANTIHYPERTENSIVE DRUGS WITH ACE TARGET.CASE FESCDIPINE II
1.Departamento de C. Químicas FESC, UNAM, 2.Facultad de C. Química UNACH, 3. Facultad de Química, UAEM, 4.Facultad de Medicina UNAM
As part of the Drug Design in Medicinal Chemistry Program of the UNAM, new methylthiomorpholinphenol compounds with cardiovascular effect, were studied. One of them, FESCDIPINE II, was an excellent antihypertensive drug, that has low toxicity and preliminary studies indicate that the Angiotensin-converting enzyme (ACE) system is the biological target of this compound.
Chromatography Workflow with Nexxis iLAB
Labtronics Inc..
In a non-integrated lab, chromatography work flow - from sample login through to reporting of results - consists of a series of separate events that are either manual, paper based processes or take place in applications that are not connected to each other.
Using LimsLink to Create an Instrument Utilization Report
Labtronics Inc..
Instrument Utilization can be defined as gaining a better understanding of how efficiently an instrument is used. An instrument utilization report will show you the amount of time an instrument is actively used for any given time period.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
Flexible Lab and Data Management for the Applied Biosystems SOLiD(TM) Next Generation Sequencing System
Genologics
The Applied Biosystems SOLiDTM system is revolutionizing genetic analysis. Its massively parallel sequencing of clonallyamplified DNA fragments provides accurate, high-throughput results for growing applications in transcriptomics, epigenomics, and whole genome and targeted resequencing, all in one platform.
Flexible Lab and Data Management for the Illumina Genome Analyzer
Genologics
The Illumina Genome Analyzer represents a breakthrough in the volume and quality of genome sequencing. The massive output of Illumina sequencing technology enables even small labs to match the sequencing capabilities of the largest genome centers just years ago. This application note details how Geneus manages the lab and data from a Genome Analyzer resequencing workflow.
Labtronics Inc..
In a non-integrated lab, chromatography work flow - from sample login through to reporting of results - consists of a series of separate events that are either manual, paper based processes or take place in applications that are not connected to each other.
Using LimsLink to Create an Instrument Utilization Report
Labtronics Inc..
Instrument Utilization can be defined as gaining a better understanding of how efficiently an instrument is used. An instrument utilization report will show you the amount of time an instrument is actively used for any given time period.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation
As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
Flexible Lab and Data Management for the Applied Biosystems SOLiD(TM) Next Generation Sequencing System
Genologics
The Applied Biosystems SOLiDTM system is revolutionizing genetic analysis. Its massively parallel sequencing of clonallyamplified DNA fragments provides accurate, high-throughput results for growing applications in transcriptomics, epigenomics, and whole genome and targeted resequencing, all in one platform.
Flexible Lab and Data Management for the Illumina Genome Analyzer
Genologics
The Illumina Genome Analyzer represents a breakthrough in the volume and quality of genome sequencing. The massive output of Illumina sequencing technology enables even small labs to match the sequencing capabilities of the largest genome centers just years ago. This application note details how Geneus manages the lab and data from a Genome Analyzer resequencing workflow.
