Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Life of a Scientific Poster...
Quick and Easy NGS Analysis with SureCal...Horizon Discovery: The Power of Personal...What is LabTube?...

Featured Products
Featured Product -  BioloMICS

Managing Pharmaceutical Lab Data Management to Ensure Compliance
In this webinar Stacey Brown and William Leonard, Senior Validation Analysts for Informatics at Thermo Fisher Scientific, will help you understand more about the complex requirements of pharmaceutical data management.
15 Years HCS: Next Gen Screening Devices Learn from Each Other. Literally. Fast Workflow Development & BigData Image Analytics Used to be a Challenge. What’s Next?
Urban Liebel, ACQUIFER, speaking at Screening Europe 2015

Market Reports
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Modification Screening Trends 2014

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Back to the Lab! Improving R&D Productivity and Efficiency with LIMS and ELNs
Datamonitor plc

The rigorous R&D processes of pharma and biotech have provided them with a wealth of data, documents and knowledge, but this information is often held in organizational silos, paper laboratory notebooks and disparate IT systems, rendering them virtually useless. Therefore, life sciences companies are implementing LIMS and ELNs to remove the silos and connect R&D groups across the enterprise.
Scientific News
Breaking Through the Barriers to Lab Innovation
Here we examine the drivers behind the move for greater innovation, the challenges and current trends in laboratory informatics, and the tools that can be used to break these barriers.
Researchers Construct Atomic Model of an Immature Retrovirus
Using molecular modeling and large-scale molecular dynamic simulation, Beckman researchers have constructed an atomic model of an immature retrovirus.
New Mathematics Advances the Frontier of Macromolecular Imaging
Berkeley Lab’s M-TIP solves the reconstruction problem for fluctuation X-ray scattering.
Exploring Living cells
JPK reports the exploration of living cells using nanoscale and single molecule techniques through the application of scanning probe microscopy.
The Perfect Partnership: Research & Industry; Software & Instrumentation. It really starts to come together at ASMS 2015
Collaboration and knowledge-sharing were evident everywhere: on the bus, in the hallways and in the bars. This article aims to capture this theme and share with you some of the fruits of this coming together of science and industry.
Designing New Pain Relief Drugs
Researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain.
Antibody Pries Loose Bacteria’s Grip
Study finds novel method of improving antibody efficacy.
CLAIRE Brings Electron Microscopy to Soft Materials
CLAIRE works by essentially combining the best attributes of optical and scanning electron microscopy into a single imaging platform.
Sample & Analysis Tracking in Oncogenomic Experiments
The study outlines Onco-STS, a web-based laboratory information management system for sample and analysis tracking in oncogenomic experiments.
Pittcon Announces Wide Variety of Short Courses
Courses range from beginner and intermediate to advanced levels.
Business News
Agilent Signs Agreement with Thermo Fisher Scientific
Agreement to exchange instrument controls to improve the productivity and user experience.
LIMS in Action at a Radiological, Environmental and Analytical Laboratory
Laboratory Information Management Systems (LIMS) specialist, Autoscribe Informatics, has published a new case study describing the use of the Matrix Gemini LIMS in a major Radiological, Environmental and Analytical Laboratory.
Sunquest Announces Roper Technologies’ Acquisition of CliniSys and Atlas Medical
Acquisitions broaden healthcare IT capabilities to connect laboratories to the community on a global basis.
Quality Systems to Acquire HealthFusion Holdings
Acquisition to accelerate cloud-based development and delivery of QSI/NextGen Healthcare core applications and elevate commitment to ambulatory services sector with addition of clients.
Autoscribe Opens Office to Support Expanding BioHub
Autoscribe Informatics celebrated the opening of a new office facility in the UK in October.
Flexibility of Matrix LIMS Enables Mortuary Management
Mortuary case study highlights tracking software capabilities Matrix Gemini LIMS from Autoscribe Informatics.
RURO Announces FreezerPro Cloud
RURO, Inc. has announced that its best-selling system, FreezerPro®, is now available as a subscription-based, cloud-hosted software service.
Allotrope Foundation Releases Allotrope Framework 1.0
Allotrope Foundation has announced a major milestone: release of the first production version of its flagship Allotrope Framework to Allotrope Foundation and Allotrope Partner Network Members.
Xavo, BSSN Software Partner
Xavo and BSSN Software are proud to announce a collaboration that integrates Seahorse Scientific Workbench and Xavo Lab Logistics.
LIMS For Petrochemical And Environmental Applications
Visitors to the PEFTEC exhibition can find out how the Matrix Gemini LIMS (Laboratory Information System) from Autoscribe Informatics can manage the large quantities of data generated as a result of laboratory testing and monitoring carried out in the Petrochemical and Environmental industries.

Managing Pharmaceutical Lab Da
01 Dec 2015
Managing Pharmaceutical Lab Da ...
More information
Digital Health World Forum
08 Dec 2015
Digital Health World Forum ...
More information
SmartLab Exchange Europe 2016
09 Feb 2016
SmartLab Exchange Europe 2016 ...
More information
IoT Tech Expo Europe
10 Feb 2016
IoT Tech Expo Europe ...
More information

The Power Decoder simulator for the evaluation of pooled shRNA screen performance
GE Healthcare Dharmacon, Inc.

Power Decoder (written in R and Python) simulates shRNA pooled screening experiments in silico to allow for the estimation of a screen’s statistical power. Populations of shRNAs were engineered in such a way that the magnitude of depletion and enrichment was known, then using the negative binomial distribution, an in silico model was developed to successfully resemble data from an actual laboratory experiment.
Knockdown of long noncoding RNAs in breast cancer
GE Healthcare Dharmacon, Inc.

RNAi global collaboration study using Lincode siRNA in a primary screen of tumor and nontumor breast cell lines. Hundreds of lncRNAs are found to affect viability and cell morphology of breast cancer. Presented at Keystone Symposia on Long Noncoding RNAs: From Evolution to Function, Mar 15 - Mar 20, 2015.
Specificity of highly potent miRNA inhibitors
GE Healthcare Dharmacon, Inc.

miRNA inhibitors are invaluable tools for elucidating the roles of miRNAs. However, potent inhibitors may also affect other miRNAs. To understand the potential cross-reactivity of miRNA inhibitors, various miRNA inhibitor designs were systematically tested. We demonstrate that mismatches both within and outside the seed region of the miRNA interfere with inhibition. Our findings indicate that features important for natural miRNA target recognition are also important for inhibitor specificity.
Alternative miRNA design for therapeutic RNAi applications
GE Healthcare Dharmacon, Inc.

For in vivo applications, the design of miRNA inhibitors and miRNA mimics must be optimized for stability and potency. However, stabilized miRNA mimic molecules can lose functionality compared to standard miRNA mimic molecules due, in part, to the activity of the stabilized passenger strand acting as a miRNA inhibitor. We discuss how mismatches affect the activity of the stabilized miRNA mimics, perhaps by generating a passenger strand that is less functional as an inhibitor molecule.
Cas9 driven by an optimal promoter improves gene editing in eukaryotic cell lines when paired with synthetic crRNA and tracrRNA
GE Healthcare Dharmacon, Inc.

Presented here are results on the efficiency of using synthetic crRNA and tracrRNA to introduce gene editing events when co-transfected with a plasmid expressing Cas9. We explored the use of antibiotic and fluorescence activated cell sorting (FACS) methods for enrichment of cells that have undergone gene editing, and the use of multiple promoters to increase efficiency of gene editing with Cas9 and synthetic tracrRNA and crRNAs.
Specificity and functionality of microRNA inhibitors
GE Healthcare Dharmacon, Inc.

Our findings indicate that features important for natural miRNA target recognition also appear to be important for inhibitor specificity. Understanding the specificity of inhibitors allows for better interpretation of inhibitor activity in endogenous systems.
Identification of microRNA targets using microRNA modulation techniques and gene expression arrays
GE Healthcare Dharmacon, Inc.

By examining the overlap of messages down-regulated by miRNA mimics and up-regulated by miRNA inhibitors, we robustly identify miRNA-regulated messages, many of which have canonical seed matches and some which are not identied by standard target prediction programs.
siRNA Screening: Development of Hit Stratification Strategies
GE Healthcare Dharmacon, Inc.

This poster compares different approaches to hit stratification and validation after an initial screen. Standard siRNA reagents deconvoluted from a pooled set of four were compared to a pooled set of four specificity enhanced reagents. High confidence hits were similar. To explore the validity of low confidence hits, a chimeric approach was used whereby a gene-specific seed sequence was introduced into a non-targeting siRNA scaffold. This work resulted in new hit stratification strategies.
The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry
GE Healthcare Dharmacon, Inc.

Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
Peanut Allergy: An epidemiologic analysis of a large database
Riley Hospital or Children at IU Health

Over three years, 700 children with a peanut story - either peanut sensitization or peanut allergy- were asked to participate in a database.
Application Notes
Global Mining Leader Implements LIMS to Support ISO 17025

Aspiring to satisfy the criteria for laboratory accreditation, Anglo American Research Labs searched for an ISO 17025 “ready” LIMS. STARLIMS aided in automating the lab to conform to ISO 17025 standards.
The ROI of LIMS Standardization

Seeking a replacement for their internally developed LIMS, ChevronTexaco selected STARLIMS to standardize five domestic US refinery plants. The system is presently in production concurrently at all five sites, with 2,500 users.
Replacing a Legacy LIMS at the Pacific Environmental Science Centre

The Pacific Environmental Science Centre (PESC) had been using a LIMS developed in the 1970s but, with multi-functionality required, covering 105 applications, and with 12 functional areas of the laboratory and around 500,000 tests conducted per year, the system was becoming increasingly more difficult and time-consuming to maintain.
Minimizing Compliance Risk at Regulated Nutrient Manufacturer

Today’s laboratories are struggling to find ways to effectively solve their two most important issues: addressing regulatory compliance, including 21 CFR Part 11, and improving inefficient processes. Fortitech Inc.’s burgeoning task of managing and documenting ingredient blend quality procedures, invoked an initiative to fully automate lab operations.
SDMS Vision Publisher Facilitating Masslynx and Empower Software Data Capture
Waters Corporation

As the volume and complexity of research data continues to grow, the use of an electronic format for laboratory record keeping is the key to simple recording and global communication of critical scientific information.
Flexible Lab and Data Management for the Applied Biosystems SOLiD(TM) Next Generation Sequencing System

The Applied Biosystems SOLiDTM system is revolutionizing genetic analysis. Its massively parallel sequencing of clonallyamplified DNA fragments provides accurate, high-throughput results for growing applications in transcriptomics, epigenomics, and whole genome and targeted resequencing, all in one platform.
Flexible Lab and Data Management for the Illumina Genome Analyzer

The Illumina Genome Analyzer represents a breakthrough in the volume and quality of genome sequencing. The massive output of Illumina sequencing technology enables even small labs to match the sequencing capabilities of the largest genome centers just years ago. This application note details how Geneus manages the lab and data from a Genome Analyzer resequencing workflow.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos