Molecular Modelling to Help Create Better, Safer DrugsHow our bodies break down the common drugs ibuprofen, diclofenac and warfarin is the subject of a new study from the University of Bristol.
ATARiS Informatics Platform Hits the JackpotATARiS is one of several tools developed at the Broad Institute to precisely tune in to the signals within noisy datasets.
New Software Spots, Isolates Cyber-attacks to Protect Networked Control SystemsSoftware algorithm detects and isolates cyber-attacks on networked control systems that are becoming increasingly important to national infrastructure
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian CancerGenedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic CellsBy genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Tissue of Origin Determines Cancer-associated CpG Island Promoter Hypermethylation PatternsMeehan, Sproul and co-workers conclude that general aberrant promoter hypermethylation in cancer does not promote tumorigenesis, but instead reinforces transcription repression inherited from pre-cancerous tissue.
Non-Genotoxic Carcinogen Exposure Induces Defined Changes in the 5-HydroxymethylomeIn a genome wide study Meehan, Moggs and MARCAR co-authors examined 5mC and 5hmC profiles of liver in control and phenobarbital treated mice. They observe dynamic and reciprocal changes in the 5mC/5hmC patterns over genes promoters that are transcriptionally up-regulated.
Are Laboratories Ready for Truly Mobile Working?Ok so we all follow the newspapers, blog sites and various other "social feeds" (as they are known), but have you ever thought if our research laboratories are ready to embrace a new way of working?
SIGLa: An Adaptable LIMS for Multiple LaboratoriesSIGLa has been developed with the aim of contributing to complex data management in the laboratory by managing large amounts of data and guaranteeing its consistency.
Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug DesignThe group of scientists performed structural analyses on biologically important molecules and their complexes with partners, hoping to contribute to molecular design for controlling biologically abnormal functions.
