Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Genedata Expressionist® Established as Data Analysis Platform for Oncological Research

Published: Friday, December 28, 2012
Last Updated: Friday, December 28, 2012
Bookmark and Share
carcinoGENOMICS and other EU-funded research consortia help Genedata advance software platform

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, has announced its successful contributions to several oncology-related research consortia, including the EU-funded carcinoGENOMICS, Newgeneris, and INCA projects. Genedata Expressionist, the company's flagship product for molecular profiling applications, was successfully used by these consortia for the analysis and management of complex high-volume, oncology-related data. Additionally, the consortia's oncology-specific requirements fueled the development of enhanced capabilities in Genedata Expressionist, which are now available to all licensees of the software. A comprehensive and enterprise-level solution, Genedata Expressionist helps to identify and understand molecular biomarkers by easily integrating transcriptomics, genomics, epigenomics, proteomics, and metabolomics data.

In implementing Genedata Expressionist for Genomic Profiling, Genedata domain experts worked closely with several EU research consortia including the carcinoGENOMICS project. carcinoGENOMICS was comprised of 20  research organizations representing the pharmaceutical industry as well as leading academic institutions from across Europe. The consortium developed a series of in vitro tests representative of various modes of carcinogenic action for the major target organs liver, lung, and kidney. This approach enables efficient assessment of a high number of compounds as required under  REACH, the European Community Regulations on chemicals and their safe use.  Moreover, this testing resulted in best practices required to successfully reduce animal testing while enabling more cost-efficient R&D processes.

"Toxicogenomics  research is generating large amounts of complex omics data and researchers are challenged to make sense of these data," noted Prof. Dr. Jos Kleinjans, scientific director of the Netherlands Toxigenomic Centre, who  is the coordinator  of the carcinoGENOMICS Project. "Genedata Expressionist helps researchers to effectively meet these challenges, by efficiently analyzing high-throughput molecular profiling data" continued Kleinjans. "Moreover, the Genedata team of scientists provides the necessary expertise to ensure the success of ambitious projects such as ours."

Researchers use Genedata Expressionist to assess assay reproducibility and predict compound carcinogenicity. Assays are based on the application of omics technologies (i.e. genome-wide transcriptomics and metabolomics) to robust in vitro systems (rat/human). Phenotypic markers for genotoxic and carcinogenic events are assessed to anchor gene expression modulations, metabolic profiles, and mechanistic pathways. Through extensive biostatistics, literature mining, and analysis of molecular-expression datasets, differential genetic pathways are identified, which are capable of predicting mechanisms of chemical carcinogenesis in vivo. Furthermore, Genedata Expressionist is able to integrate transcriptomics and metabolomics data to provide a holistic understanding of systems biology and build an iterative in silico model of chemical carcinogenesis.

Recently, Genedata also contributed its software solutions to a number of innovative EU-funded, oncology-focused projects, including:

*    NewGeneris - the consortium successfully investigated chemical risks concerning the development of childhood cancer and immune disorders and the role of prenatal exposure to genotoxic chemicals through maternal intake of  food during pregnancy.
*    INCA - the consortium successfully examined the role of chronic viral infections in the development of cancer.

"Genedata is proud to work with some of the  leading scientists and research organizations worldwide who are  fighting some of the most life-threatening diseases," said Dr. Othmar Pfannes, CEO of Genedata. "The know-how and experience gathered in such collaborations continues to drive the advancement of Genedata Expressionist - with the enhancements now available to all licensees of the system."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

GSK Implements Genedata Biologics as Antibody Discovery Platform
Genedata Biologics integrates GlaxoSmithKline's Biopharm Discovery workflows across multiple Biopharm R&D groups and sites
Thursday, June 12, 2014
Genedata Showcases Integrated Analysis & Image Management Solution for Phenotypic Screening
Regardless of instrument or application, Genedata Screener® for High Content Screening enables time-efficient workflow for analysis of high-content experiments
Friday, February 21, 2014
Genedata Announces New Data Analysis Platform for Next-Gen Oncology Drug Discovery
AstraZeneca and Genedata detail a data analysis platform for compound combination experiments in oncology and other therapeutic areas
Monday, February 03, 2014
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Chooses Genedata Expressionist for Oncology Research
Leading clinical-research institute of the Robert Bosch Stiftung uses Genedata Expressionist for managing, processing, and interpreting clinical NGS data
Monday, January 27, 2014
Biogas Consortium Using Genedata Selector for Metagenomics-based Process Optimization
Genedata Selector platform to manage, analyze, and integrate complex microbial genomes and strains will be showcased in 5th Annual NGS Conference Poster Session
Saturday, November 23, 2013
Sanofi Adopts Genedata Biologics for Integrated Biopharma R&D Process Support
Genedata Biologics will be implemented at multiple Sanofi R&D sites and departments to improve biologics discovery throughput and process efficiency.
Sunday, November 10, 2013
Evonik and Genedata broaden their collaboration with the Genedata Selector biotechnology data management platform
Genomic strain data management solution supports Evonik growth in biotechnology
Sunday, September 22, 2013
AB SCIEX, Genedata and LECO Announce Partnership
New collaborative software system will enable metabolomics researchers to comprehensively process and analyze experimental data across different GC/MS and LC/MS platforms.
Tuesday, July 02, 2013
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Saturday, April 06, 2013
Genedata Expressionist for Mass Spectrometry Showcased at 2013 Biotherapeutics Analytical Summit
Genedata Expressionist will be demonstrated as a platform for automating and standardizing protein characterization that helps eliminate data analysis bottlenecks
Wednesday, March 13, 2013
Ono Pharmaceutical Selects Genedata Expressionist for Mass Spectrometry
Global leader in drug discovery advances targeted proteomics and metabolomics with extended use of Genedata Expressionist®
Sunday, February 10, 2013
Genedata Screener Adopted for all Plate-based Screening by Major Pharmas
More than half of the top 25 pharmaceutical companies now use Genedata Screener® to support plate-based screening, including High Content, Label-free, and Ion Channel Screening
Sunday, January 20, 2013
Genedata Biologics for Streamlined Protein Engineering at PEGS Europe
UCB Pharma and Genedata will showcase data management and workflow system that captures production and characterization data for biotherapeutics and reagents
Sunday, November 11, 2012
UCB Pharma Advances Next-Generation Antibody Discovery with Genedata Biologics
Leader in protein therapeutics development extends use of Genedata Biologics for next-generation antibody-based therapeutics R&D
Thursday, September 20, 2012
Genedata and Insilico Biotechnology Integrate Industrial Biotechnology Platforms
Integrative bioinformatics platform will streamline and accelerate production strain optimization for fermentation-based applications
Thursday, September 20, 2012
Scientific News
Editing of LIMS Data Made Faster and More Efficient in Matrix Gemini
The latest version of the Matrix Gemini LIMS (Laboratory Information Management System) from Autoscribe Informatics now provides faster and more efficient editing of LIMS data by eliminating the need for a second editing screen.
Breaking Through the Barriers to Lab Innovation
Here we examine the drivers behind the move for greater innovation, the challenges and current trends in laboratory informatics, and the tools that can be used to break these barriers.
Researchers Construct Atomic Model of an Immature Retrovirus
Using molecular modeling and large-scale molecular dynamic simulation, Beckman researchers have constructed an atomic model of an immature retrovirus.
New Mathematics Advances the Frontier of Macromolecular Imaging
Berkeley Lab’s M-TIP solves the reconstruction problem for fluctuation X-ray scattering.
Exploring Living cells
JPK reports the exploration of living cells using nanoscale and single molecule techniques through the application of scanning probe microscopy.
The Perfect Partnership: Research & Industry; Software & Instrumentation. It really starts to come together at ASMS 2015
Collaboration and knowledge-sharing were evident everywhere: on the bus, in the hallways and in the bars. This article aims to capture this theme and share with you some of the fruits of this coming together of science and industry.
Designing New Pain Relief Drugs
Researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain.
Antibody Pries Loose Bacteria’s Grip
Study finds novel method of improving antibody efficacy.
CLAIRE Brings Electron Microscopy to Soft Materials
CLAIRE works by essentially combining the best attributes of optical and scanning electron microscopy into a single imaging platform.
Sample & Analysis Tracking in Oncogenomic Experiments
The study outlines Onco-STS, a web-based laboratory information management system for sample and analysis tracking in oncogenomic experiments.

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos