Thermo Fisher Scientific Inc., a world leader in serving science, has introduced Thermo Scientific TraceFinder software version 3.0, designed to enhance quantitation and targeted screening workflows in clinical research, forensic toxicology, food testing and environmental laboratories using gas or liquid chromatography and mass spectrometry.
Designed to optimize laboratory productivity, TraceFinder software now features Intelligent Sequencing, which allows users to specify protocols for a variety of fault conditions to minimize the need to rerun experiments. For example, if a sample is too concentrated, indicating possible carryover, Intelligent Sequencing can be programmed to automatically inject a solvent blank and then re-inject the original sample to maintain throughput. Intelligent Sequencing can address a wide range of sample types and fault conditions.
To perform targeted screening, methods can now be set up in three simple steps: select screening type, select or import the target compound database, and then choose the identification and confirmation settings. High confidence in results is supported by multiple forms of verification, including retention time, isotope pattern, fragment confirmation and library matching.
TraceFinder software now also supports “semi-quantitation,” providing a quantitative workflow for estimating the concentration of a target compound using a calibration curve from a linked compound, or by comparing it to an internal standard. This type of analysis can now be performed using a routine, automated workflow, saving time and effort compared to previous protocols.
The software offers a simple workflow-driven method setup with fully automated data acquisition, data processing and reporting. Methods can be shared easily between instruments and laboratories. A range of preconfigured methods can enable new instruments to become productive quickly. Method development is further facilitated using TraceFinder 3.0 software’s extensive Compound Database (CDB).
Data review is customizable, and multiple flags can be assigned for quick identification of problems within a data set. Data review panes can be arranged for straightforward data evaluation, including use of multiple monitors. Multi-peak review capabilities allow viewing all of the compound peaks for one sample or viewing a specific compound across a batch of samples.