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Saturday, April 19, 2014
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ChemoSoft: a new chemometric software for non-chemometricians
Christophe B.Y. Cordella

Professional applications such as those provide by some software editors and free downloadable toolboxes developed for Matlab®, R, Octave or Scilab propose many computation tools. But, to our best knowledge, very few are usable by neophytes or anyone that are not skilled with chemometrics or statistics. ChemoSoft is the first chemometric software designed for non-chemometricians.

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Rapid Identification of Microorganisms by Touch Spray and Paper Spray Ambient Ionization
Ahmed M. Hamid, Alan K. Jarmusch, Valentina Pirro and R. Graham Cooks

The rapid and accurate identification of microorganisms is necessary in order to improve public health. Molecular-based identification allows for rapid patient treatment and provides more accurate diagnoses, two crucial aspects for successful treatment, yet a great challenge. In this work PS-MS, an existing ambient method, and TS-MS, a newly developed technique, are being utilized in the rapid discrimination of microorganisms (<2 min).

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Processing and Managing Analytical Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Michael Boruta and Sanjivanjit K. Bhal, Advanced Chemistry Development, Inc.

This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.

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An Integrated Solution for Automated Nanoliter Hit-Picking at BioFocus
Joby Jenkins1, Dr Manuel Baader2 , Chloe Carter1, Stephen Starkie1

This poster describes a section of BioFocus’s screening workfolow where mosquito X1 is integrated with a RapidStak plate stacker (Thermo Scientific) using TTP LabTech’s CherryPicker software. This allows the mosquito X1 to work unattended for extended periods. The CherryPicker software drives the system automatically by converting pick lists provided by BioFocus’ LIMS system into mosquito protocols, and feeding appropriate plates via the RapidStak.

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Rapid Scale-up of Exome Sequencing Research using a Commercial Lab and Data Management Solution
Johanna Swanson, Craig Parman and Mike Sanders

In mid-2009 The Nickerson Lab in the Department of Genome Sciences at the University of Washington faced the daunting task of rapidly scaling up their next generation sequencing laboratory. Given the enormous amount of data to be generated, a critical part of this scale-up was picking the right LIMS solution. This system needed to handle data flow from sample submission to results reporting.

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Protein array-based screening of autoantibody signatures
Zingaretti C., Arigò M., Colombatto P., Brunetto M., Muratori L., Bonino F., Bianchi F., Pagani M., De Francesco R., Abrignani S., Bombaci M.

The evidence for an association between autoimmune diseases and chronic HCV infection has been clearly established. To this aim, a protein array was employed to analyze serum samples of HCV patients w/wo autoimmune complications, of patients with autoimmune hepatitis but not infected with HCV and of healthy donors as controls. A panel of autoantigens able to discriminate among the three groups of patients was identified for potential use as biomarkers.

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Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
M. Saqib Baig and N. Manickam

The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.

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Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2, 3-dioxygenase involved in degradation of polychlorinated biphenyls
M. Saqib Baig and N. Manickam

The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the docking results. The binding properties of these biphenyl compounds along with identification of critical active site residues could be used for further site-directed mutagenesis experiments in order to identify their role in activity and substrate specificity.

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Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Manoj Hariharan , Naveen Raj

Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.

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Treatment of Plaque Infections and Periodontitis using Stem Cells- A New Prospect
Manoj Hariharan , Naveen Raj

Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This paper gives a short overview of stem cells of dental origin.

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Showing Results 1 - 10 of 22
Scientific News
BioClinica and Rutgers University Announce Research Project Results
Scientific Partnership Aims to Expand Automation of Clinical Trial Image Data Analysis
Leading Japanese CRO Standardizes on Thermo Scientific Watson LIMS
JCL Bioassay uses Thermo Scientific Watson LIMS to optimize communication, data management and quality control during U.S. expansion.
How it Works: Advanced Data Analysis Using Visualisation
Visualisation is a powerful tool for those working in molecular biology, here Qlucore offers a five-step method to ensure repeatable and significant results.
Molecular Modelling to Help Create Better, Safer Drugs
How our bodies break down the common drugs ibuprofen, diclofenac and warfarin is the subject of a new study from the University of Bristol.
ATARiS Informatics Platform Hits the Jackpot
ATARiS is one of several tools developed at the Broad Institute to precisely tune in to the signals within noisy datasets.
New Software Spots, Isolates Cyber-attacks to Protect Networked Control Systems
Software algorithm detects and isolates cyber-attacks on networked control systems that are becoming increasingly important to national infrastructure
Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Tissue of Origin Determines Cancer-associated CpG Island Promoter Hypermethylation Patterns
Meehan, Sproul and co-workers conclude that general aberrant promoter hypermethylation in cancer does not promote tumorigenesis, but instead reinforces transcription repression inherited from pre-cancerous tissue.
Non-Genotoxic Carcinogen Exposure Induces Defined Changes in the 5-Hydroxymethylome
In a genome wide study Meehan, Moggs and MARCAR co-authors examined 5mC and 5hmC profiles of liver in control and phenobarbital treated mice. They observe dynamic and reciprocal changes in the 5mC/5hmC patterns over genes promoters that are transcriptionally up-regulated.
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