Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian CancerGenedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic CellsBy genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Tissue of Origin Determines Cancer-associated CpG Island Promoter Hypermethylation PatternsMeehan, Sproul and co-workers conclude that general aberrant promoter hypermethylation in cancer does not promote tumorigenesis, but instead reinforces transcription repression inherited from pre-cancerous tissue.
Non-Genotoxic Carcinogen Exposure Induces Defined Changes in the 5-HydroxymethylomeIn a genome wide study Meehan, Moggs and MARCAR co-authors examined 5mC and 5hmC profiles of liver in control and phenobarbital treated mice. They observe dynamic and reciprocal changes in the 5mC/5hmC patterns over genes promoters that are transcriptionally up-regulated.
Are Laboratories Ready for Truly Mobile Working?Ok so we all follow the newspapers, blog sites and various other "social feeds" (as they are known), but have you ever thought if our research laboratories are ready to embrace a new way of working?
SIGLa: An Adaptable LIMS for Multiple LaboratoriesSIGLa has been developed with the aim of contributing to complex data management in the laboratory by managing large amounts of data and guaranteeing its consistency.
Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug DesignThe group of scientists performed structural analyses on biologically important molecules and their complexes with partners, hoping to contribute to molecular design for controlling biologically abnormal functions.
Thermo Scientific Launches European Seminar Series: “New Frontiers in Water Analysis”Seminars will feature new Thermo Scientific water analysis products and solutions.
SRI Speeds Development of Genome-Scale Models of Metabolic NetworksThe new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels.
ATL and EnvironmentalReports PartnerPartnership aims to provide laboratories with the ability to manage all operational data and easily achieve regulatory compliance goals
