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A Sandwich-Injection Method for Microchip Electrophoresis
Gang Li, Gui-Sheng Zhuang, Hai-Bin Zhu, Hui-Qing Jin and Jian-Long Zhao

We present a sandwich-injection method for controlling discrete sample injection in µ-CE. This method involves four accessory arm channels in which symmetrical potentials are loaded to form a unique parallel electric field distribution to confine the spreading of sample plugs and prevent sample leakage. The virtues of the novel injection technique were demonstrated with numerical models and experiments.

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Large-scale Microarray Analysis of Protein and mRNA Level Changes in HL-60 Cells
Pavel Simara, Irena Koutna, Stanislav Stejskal, Martina Peterkova, Petr Krontorad, Zdenek Rucka

In this study we compare methods for large-scale microarray analysis of protein and RNA level changes in HL-60 cells, responding to differentiation stimuli. Using microarrays we have found, that level of several proteins was either up- or down-regulated after cell differentiation. In some cases there was significant correlation with appropriate genes.

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Preliminary Report: The Geriatric Propamed Study: Prospective pharmacopgenetics in geriatrics
Dr LS Griffith, Dr L Chialda and Dr A Pahl

In a worldwide first proscpective phamacogenetic study preliminary results show reduction of adverse drug reactions and hospitilisation stays for geriatric patients after pharmacogenetic testing and medication interaction analysis to fit the medicine to the patient.

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Microfluidic Platform for Point-of-Care Blood Typing
B. Scheufele, R. Gronmaier, J. Claussen, S. Haeberle, J. Kohnle, J. Ducree, R. Zengerle, H. Northoff and F.K. Gehring

We have developed a microfluidic platform for mass sensitive analysis of whole blood that allows fast and reliable Point-of-Care blood typing of the AB0 system requiring small sample volumes. Potential application areas of the microfluidic platform include emergency medical aid, clinics and doctor's surgeries.

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Development of a Lab-on-a-Chip for the Characterization of Human Cells
Richter, L., Stepper, C., Mak, A., Brückl, H. and Ertl, P.

Cell chips are developed to continuously monitor mammalian cell population dynamics in a non-invasive manner. In the presented work we describe the design, fabrication and characterization of a lab-on-a-chip for quantitative cell analysis.

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Label-free Identification of Microorganisms using a Contact-less Dielectric Microsensor
Ertl, P., Richter, L., Reinthaler, A., Stepper, C., Mak, A., Kast, M., Heer, R. and Brückl, H.

Microfabricated biochips are developed to continuously monitor cell population dynamics in a non-invasive manner. In the presented work we describe the novel combination of contact-less dielectric microsensors and microfluidics to promote biofilm formation for quantitative cell analysis.

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Design, Manufacturing and Test of Disposable Microfluidic System for Blood-Plasma Separation
M. Kersaudy-Kerhoas, F. Amalou, D. Kavanagh, S. Marson, U. M. Attia, P. Summersgill, T. Ryan and M.P.Y. Desmulliez

Prenatal diagnosis to determine the outcome of pregnancies and detect conditions that may affect future pregnancies has risen as a big issue in the broad public. Analysis of fetal genetic material extracted from maternal blood is a smart alternative to invasive prenatal testing.

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EasyBeacons™ - new Probes Ideal for Realtime PCR Detection of Methylation Status of Single CpG Duplets and SNPs
K. Skadhauge, C. Nielsen & U.B. Christensen

The EasyBeacons™ presented here are based on the novel technology Intercalating Nucleic Acid, INA®, linked to a fluorophore and a quencher. INA® is composed of normal DNA nucleotides and Intercalating Pseudo Nucleotides (IPNs). The fact that the EasyBeacons™ are mostly composed of normal DNA nucleotides means that in many respects EasyBeacons™ behave like DNA based probes, allowing use of standard buffers, primers and enzymes and hence reduces the optimisation efforts.

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Novel Fluidics Microbead Trap/Flow Cell Enhances Speed/Sensitivity of Bead-Based Bioassays Up to 5-Fold
RM Ozanich, CJ Bruckner-Lea, JW Grate, MG Warner, BP Dockendorff, KC Antolick, HC Edberg, LH Johnson, AN Easterday

Pacific Northwest National Laboratory (PNNL) has developed a micro/nano particle trap that allows surface-functionalized magnetic or non-magnetic particles to be trapped with subsequent perfusion of sample, reagents and wash solutions, yielding significant (up to 5-fold) improvements in assay speed and sensitivity, while significantly reducing sample matrix effects.

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Showing Results 91 - 100 of 141
Scientific News
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Lab-on-a-Chip to Study Single Cells
Scientists at EPFL have developed a new lab-on-a-chip technique to analyze single cells from entire population. The new method, which uses beads and microfluidics can change the way we study mixed populations of cells, such as those of tumors.
Mini Synthetic Organism Instead Of Test Animals
Using a compact multi-organ chip, and those of three separate microcircuits, researchers can study the regeneration of certain kidney cells.
Rapid Test Kit Detects Dengue Antibodies from Saliva
IBN’s MedTech innovation simplifies diagnosis of infectious diseases.
UBC Engineers Develop Biochem Point-of-Care Lab for Smartphones
UBC Okanagan takes lab on a chip technology to a new inexpensive level.
New Way To Model Sickle Cell Behavior
Microfluidic device allows researchers to predict behavior of patients’ blood cells.
Watching How Cells Interact
New device allows scientists to glimpse communication between immune cells.
Extracting Tumor Cells From Blood
UCLA scientists use ‘NanoVelcro’ and temperature control to extract tumor cells from blood.
Sweeping Cells Apart For Use In Medical Research
Scientists have developed a new method to separate cells, which could lead to more efficient medical research.
How Bacteria Control Their Size
By monitoring thousands of individual bacteria scientists discovered how they maintain their size from generation to generation.
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