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A microfluidic approach for the directed evolution of proteins by retroviral display
Lucia Granieri, Jean-Christophe Baret, Andrew D. Griffiths and Christoph A. Merten

The model system used here is based on retroviral particles displaying tPA, a protein used in current emergency therapies of myocardial infarction and stroke. Single tPA variants were encapsulated into aqueous droplets, at a frequency of ~10Kilohertz and the enzymatic activity was monitored using a fluorescence assay. Active variants could be clearly distinguished from inactive variants or variants incubated with the endogenous inhibitor PAI-1.

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A high-throughput protein array-based approach
Rachel Van Dyk, Claudia Kirisits, Paul Potter, Fook Tim Chew, Reinhard Hiller

Here we present a novel discovery-oriented high-throughput approach to the screening of allergen reactivates in crude biological extracts is presented using seafood allergens as an example. The CPGR workflow permits the effective screening of hundreds of putative allergens in parallel using minute amounts of patient serum and constitutes a cost-efficient allergen-specific antibody screening method for a routine diagnostic setting.

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Development of a High-Throughput Microarray for Evaluating CYP1A1 Induction
Megan Mason, XinXin Ding, Jonathan S. Dordick

The aim of this study is to produce a vector capable of expressing green fluorescent protein (GFP) when exposed to a CYP1A1 inducer.

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Bio-analytic silicon chips for the detection of developmentalneurotoxic effects of chemicals and drugs in the context of the European REACH program
S. Buehler , Helene Altrichter , P. J. Koester , C. Tautorat , Ralf Ehret ,Werner Baumann , Jan Gimsa

Bio-analytic silicon chips can be used to investigate stem cell differentiation into neurons and for the in vitro on-line monitoring of cellular reactions under well controlled experimental conditions. Chip systems allow for a parallel, label-free and non-invasive measurement of different parameters by CMOS silicon microsensors by the application of potential neurotoxic and developmental neurotoxic substances.

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Bio-analytic silicon chips for the detection of developmentalneurotoxic effects of chemicals and drugs in the context of the European REACH program
S. Buehler , Helene Altrichter , P. J. Koester , C. Tautorat , Ralf Ehret ,Werner Baumann , Jan Gimsa

Bio-analytic silicon chips can be used to investigate stem cell differentiation into neurons and for the in vitro on-line monitoring of cellular reactions under well controlled experimental conditions. Chip systems allow for a parallel, label-free and non-invasive measurement of different parameters by CMOS silicon microsensors by the application of potential neurotoxic and developmental neurotoxic substances.

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Modular Glass Chip System for the Acquisition of the Electric Activity and Physiological Parameters of Differentiated Stem Cells
P. J. Koester, J. Sakowski, S. M. Buehler, C. Tautorat, H. Altrichter, W. Baumann and J. Gimsa

The EU chemical policy REACH, effective on June 2007, regulates the registration, evaluation and authorization of chemicals. Investigations on the effects of neurotoxic and developmental-neurotoxic substances are required by European and US-American test guidelines. However, at the moment these tests are based on animal experiments contradicting society claims to abolish animal experiments and to implement the 3R-principle. The resulting problem is… How to pair REACH and the 3Rs?

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New Microarray Substrate for Fluorescent Signal Enhancement
Wayne Moore, Svetlana I. Novikova, David Moore, Lisa Jolin and Cindy Smith.

Microcosm BioBright slides (patent pending) are designed as a plug-and-play alternative to commercially available microarray substrates for use with different microarray platforms (oligo, miRNA or protein).

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Interactive Transcription Maps Over Microarray Data
Petr Krontorad, Irena Koutna and Michal Strehovsky

For final description of microarray experiment results it is necessary to use some statistically robust method. Transcription maps (TM) are used to map results of gene expression analysis into individual chromosomes. We have implemented graphical tool for interactive display of TMs. This tool allows displaying of arbitrary information for each gene.

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Expression Profiling of CD34+ of Peripheral Blood of Patients with Lymphoma During ex vivo Granulocytic Differentiation
Irena Koutna, Lenka Tesarova, Martin Klabusay, Petr Krontorad, Michal Strehovsky, Martina Peterkova and Viera Hrabcakova

On the basis of global expression data analysis we have concluded that population of CD34+ cells from patients with lymphoma shows different expression status during ex-vivo differentiation. And thus we assume that CD34+ population is not suitable for autologous transplantation. We have used cDNA microarrays technology to obtained precise expression profiles.

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Showing Results 91 - 100 of 153
Scientific News
Characterizing the Micro-Mechanical Properties of Soft Materials, Tissues and Cells
Ernst Breel of Optics11 discusses the current problems with characterizing the mechanical properties of soft materials, focusing on how the company's Piuma Nanoindenter can assist researchers.
Breath Test For Detecting Head And Neck Cancer
A portable device can detect the presence of certain types of cancer in people's breath.
Using Sound Waves To Detect Rare Cancer Cells
Acoustic device can rapidly isolate circulating tumor cells from patient blood samples.
Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
Dartmouth researchers and bioengineers develop novel system to improve cancer treatment.
Mechanically Stimulating Stem Cells
MIT biological engineering graduate student Frances Liu is studying ways to alter mechanical properties of cell environments to produce desired chemical outputs.
Catching And Releasing Tiny Molecules
New technique for sorting biomolecules could lead to efficient clinical diagnostics and chemical purification.
A Single-Cell Breakthrough
UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.
Tiny Optical Antennas: A Nano Revolution
Newly developed tiny optical antennas, which function like spotlights at the nanoscale, offer the potential to measure food safety, identify air pollutants and even quickly diagnose and treat deadly diseases, like cancer.
Solving The Mystery Of The Dancing Droplets
Years of research satisfy a graduate student's curiosity about the molecular minuet he observed among drops of ordinary food coloring.
Hearts On A Chip To Aid Drug Screening
UC Berkeley bioengineers have developed a heart-on-a-chip which can be used for drug safety screening.
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