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Friday, April 18, 2014
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Quality Monitoring on Human 14K Oligo Chips at the University of Calgary
Xiuling Wang, Stephen M. Robbins and Mayi Arcellana-Panlilio,

The production of microarrays needs to be carefully monitored and quality control tests done to track systematic effects and performance variations over time to maximize the possibility of getting high quality data.

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New Platforms and Systems for DNA Microarrays
B. Henze, B. Saal, D. Drutschmann, K. Wellesen and P. Schüßler

Operon has designed probes of different lengths to various positions in the Open Reading Frames (ORFs) and the results clearly show that 70mers offer the optimal combination of specificity and sensitivity.

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S&S® Serum Biomarker Chip Displays Specificity & Reproducibility for 120 Different Human Biomarker Profiles
Christopher C. Zarozinski, Damon W. Pawlak, Brett A. Stillman, Michael A. Harvey and Breck O. Parker

We introduce a unique tool for the determination of relative abundances for human serum biomarkers. Conceptually similar to DNA microarrays, the S&S® Serum Biomarker Chip (SBC) is a single capture antibody array that was developed for comparative analysis of serum samples in order to identify differences or similarities in protein expression profiles.

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SPR Imaging of Protein Microarrays for Detection of Antibody Binding
J.B. Beusink, G.A.J. Besselink and R.B.M. Schasfoort

In our study we have used the imaging SPR Instrument for Biomolecular Interaction Sensing (iSPR-IBIS) (IBIS Technologies BV, Hengelo, The Netherlands), for monitoring the binding of biomolecules to a protein array in a fully automated manner. A TopSpot instrument from BioFluidix GmbH (Freiburg, Germany) was used to spot the protein array.

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Fully Automatic Analysis of DNA Microarray Images
S.Mitterhuber, B.Petersch and O.Serrano

During the last years, the advent and rapid development of DNA microarray techniques has revolutionized genetic research in life sciences. We are presenting a new stand-alone software for fully automated analysis of microarray images. It employs a number of novel image processing algorithms for grid detection and spot segmentation which assure high calculation speed and accuracy.

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Design and Functional Analysis of ssDNA Directed Assembly in Protein Array
Ng Jin Kiata, Parayil Kumaran Ajikumara, Tang Yew Chunga, Lee Jim Yanga, Gregory Stephanopoulosa and Too Heng-Phona

The present poster discusses the fabrication and evaluation of a new platform called “Spatially addressable protein array” (SAPA). By exploring the specificity of DNA hybridization, ssDNA-antibody conjugates would capture the antigen from complex biological samples in milieu and spatially addressed to specific location on the oligo array for detection.

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Automated Multi-Layered Multiplex Assay Production with Inkjet Technology
Susan Seaton, Duncan Hall and Howard Manning

This work reports on the production and exact reproducible nature of the Aj120 Inkjet Microarray Spotter when printing multiple droplet microarrays. This has lead to successful collaborations between Arrayjet and a number of scientific groups furthering the use of this novel method of non-contact printing within the microarray field, a few of which are highlighted here.

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Prediction of Protein-to-Protein Interactions
C.Gilissen, P.Groot, P.Lucas, J.Veltman, A.GeurtsvanKessel and M.Egmont-Petersen

We use local extrema in microarray time series data as the basis for discretisation. By comparing discretised gene expressions using similarity functions, we discover putative protein-to-protein interactions. We validate the results by use of public true positive and true negative databases for protein-to-protein interactions and demonstrate the high predictiveness of these local extrema as a time series feature.

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Constructing Directed Metabolic Networks from Microarray Data
J. M. Easton, T. N. Arvanitis, A. Peet and M. Viant

Although it has been several years since metabolic networks became a commonly used analysis technique in bioinformatics, the question of how best to construct them from experimental data is still not satisfactorily resolved. Here we present a method for the construction of directed metabolic networks from microarray datasets using an enhanced version of the KEGG LIGAND database.

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Showing Results 91 - 100 of 124
Scientific News
Chips that Listen to Bacteria
Researchers have developed a chip that enables them to electrochemically image the signaling molecules from colonies spatially and temporally.
Researchers Find that Going with the Flow Makes Bacteria Stick
In surprising new discovery, scientists show that microbes are more likely to adhere to tube walls when water is moving.
Microfluidics Device Could Help Diagnose Pancreatic Cancer in Minutes
This is the first time material larger than a single-celled organism has successfully moved in a microfluidic device.
Channel-Free Microfluidic Technology for Molecular Testing Developed
The Smart FilmCARD would be the first microfluidic device in the diagnostics industry with no channels included in its design.
All-Aqueous Multiphase Microfluidics
This paper reviews recent progress in the generation of all-aqueous emulsions and jets in microfluidic systems.
Rapid Sub-attomole MicroRNA Detection on a Portable Microfluidic Chip
Researchers describe two key technologies to solve one of the major issues for point of care testing application.
A Microchip for Metastasis
MIT researchers design a microfluidic platform to see how cancer cells invade specific organs.
New Clues to How Bacteria Evade Antibiotics
Scientists have made an important advance in understanding how a subset of bacterial cells escape being killed by many antibiotics.
Microfluidics for Synthesis of Peptide-Based PET Tracers
Microfluidics is a very promising technology to meet the increased demand for peptide-based PET tracers.
Self-Steering Particles Go with the Flow
Asymmetrical particles could make lab-on-a-chip diagnostic devices more efficient and portable.
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