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Friday, July 25, 2014
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Prediction of Protein-to-Protein Interactions
C.Gilissen, P.Groot, P.Lucas, J.Veltman, A.GeurtsvanKessel and M.Egmont-Petersen

We use local extrema in microarray time series data as the basis for discretisation. By comparing discretised gene expressions using similarity functions, we discover putative protein-to-protein interactions. We validate the results by use of public true positive and true negative databases for protein-to-protein interactions and demonstrate the high predictiveness of these local extrema as a time series feature.

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Constructing Directed Metabolic Networks from Microarray Data
J. M. Easton, T. N. Arvanitis, A. Peet and M. Viant

Although it has been several years since metabolic networks became a commonly used analysis technique in bioinformatics, the question of how best to construct them from experimental data is still not satisfactorily resolved. Here we present a method for the construction of directed metabolic networks from microarray datasets using an enhanced version of the KEGG LIGAND database.

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Biosensors using Surface Plasmon Resonance Dynamic Imaging
J. Hottin, J. Spadavecchia, M. Canva, E. Maillart, M. Anger-Leroy and P. Kerourédan

We study the optical response of a SPRi detection system, characterizing temperature, stringency and time dependence of molecular interactions for the development of a DNA biochip. We are adapting this system and improve its robustness developing applications, as a 900 spots microarray identifying 65 mutations of the cystic fibrosis, for medical uses and industrial commercialization.

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A Novel Array-Based Assay for the Detection of IgG-Mediated Food Intolerance
Andrew Macdonald, Michael J. Walker, Michael S. Walker and Julie G. Reeve

The Genarrayt 200+ Foods IgG test comprises of glass slides onto which 16 microarrays of over 200 different foods have been printed. Each microarray includes standards for quantitation and positive and negative controls for quality control. Food IgGs are detected by a novel fluorescent dye labelled anti-human IgG conjugate and results are measured using a laser scanner. Fluorescence intensity is directly proportional to antibody activity in the sample.

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Clinical Validation of a Protein Microarry Assay for Diagnostics of Autoimmune Disease
S. Judice, D. Pawlak, H Appelhans, A. Frisse, M. Harvey and B. Stillman

We have developed an autoantigen microarray that will allow laboratories to measure the presence of autoantibobies associated with different collagenois and vasculitis-related autoimmune diseases for a single serum sample.

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Simplifying the Flow of Drug Discovery Data
Dr. Jonathan M.R. Davies

Regardless of research disciplines, scientists need to easily reach the information pertinent to their research. Ideally this data access is easy. Researchers also need the ability to ‘move the data around’ to gain a better view or different perspective. This data manipulation needs to be straightforward. Incorporating the varying views and information required by different scientific disciplines is a considerable challenge.

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DNA Microarrays for Microbiological Diagnosis in Stem Cell Cultures
F. Cobo, A. Nieto, P. Catalina, JL. Cortés, A. Barroso, C. Cabrera, R. Montes, A. Barnie and A. Concha

In stem cell cultures there is the possibility of infectious disease transmission to the recipients. Any microbial contamination of the donor`s biological products or introduced during the manufacturing process can potentially present a serious hazard to the recipients. The majority of potential contaminants are mycoplasma and other bacterias, yeasts and fungi. Moreover, viral and prion contamination of cell cultures and “feeder” cells is also a common risk.

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New Methods for Rapid Isothermal Amplification and Detection of Short DNA Sequences

Goal: • Rapid, sensitive, specific, low tech, portable DNA diagnostic device • Detection of clinical pathogens: SARS pathogen, Streptococcus pneumoniae, HSV I & II and biothreat agents: Bacillus anthracis, Brucella species • Detection of single nucleotide polymorphisms (SNPs) • Multiplexed detection format

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Biomathematical Information Compression and Signal Extraction for Gene Expression Microarray Data Analysis
Sofiane Lariani, Elena Comelli, Patrick Descombes and Martin Grigorov

Gene expression Microarray data covers both signal (active key genes) and noise. A tentative to recognize any genes expression pattern without clearing the data is like recognizing faces and details on a jammed TV screen. Noise in this context can be related to fluctuation due to the experimental condition, to outliers, and also genes presenting no modulation between groups. In this work we present a biostatisticalmethod for noise filtering and statistical significance assessment.

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Showing Results 101 - 110 of 127
Scientific News
Researchers Invent Nanotech Microchip to Diagnose Type-1 Diabetes
The cheap, portable, microchip-based test could speed up diagnosis and enable studies of how the disease develops.
Revealing the Role of “Precocious” Dendritic Cells in Inflammatory Response
Discovery makes it possible for researchers to explore how these “precocious” cells escalate the body’s immune response when the body is under attack.
New NIST Metamaterial Gives Light a One-Way Ticket
The device could someday play a role in optical information processing and in novel biosensing devices.
Automating Laboratory-On-A-Chip To Cut Healthcare Costs
Computer programming language automates “laboratory-on-a-chip” technologies and has potential to improve and reduce cost of healthcare.
Chemical Sensor on a Chip
Using miniaturized laser technology, a tiny sensor has been built at the Vienna University of Technology which can test the chemical composition of liquids.
Miniature Gas Chromatograph Could Aid Early Crop Disease Detection
About the size of a 9-volt battery, the technology’s portability could provide farmers with a tool to quickly evaluate the health of their crops.
Ultra-Sensitive Nano-Chip for Early Cancer Detection
Device is able to detect very low concentrations of protein cancer markers, enabling diagnoses of the disease in its earliest stages.
Stanford Research Leads to New Understanding of How Cells Grow and Shrink
Researchers use new techniques to document how cells can conceal growth and then suddenly swell up.
Bone Marrow-on-a-chip Unveiled
Device gives scientists a tool to test the effects of new drugs and toxic agents on bone marrow.
New Lab-on-a-Chip Device Overcomes Miniaturisation Problems
The novel technique involves printing a pattern of miniscule droplets of a special solvent onto a gold-coated or glass surface.
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