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Fast Development Strategy: One-Week-to-Chip
K.S.Dresse, G.Munchow and M.Ritzi

Mass manufacturing techniques like injection molding and lamination processes that allow the production of final disposable products at reasonable costs. What is needed is a process that allows fast tests of concepts and for the validation of the final chip design. As such tests pick up more and more speed the more you can rely on already established elements.

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Turning Valves for Lab-on-a-Chip Applications Enable Directional Flow and Portion Out Pre-Defined Volumes
R. Gransee, D. Dadic, F. Doffing, E. Schaeffer and K. S. Drese.

In this study the design and the realization of low-cost valves suitable for the integration into disposable polymer chips is presented. In contrast to commonly used sandwich-setups a plain design consisting of a simply structured polymer chip and a cover membrane is used.

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A Valve-Controlled Microfluidic Sysytem for Rapid Two-Dimensional Electrophoresis
Yiqi Luo, Bo Huang, Michael P. Bokoch, Richard N. Zare.

Two-dimensional electrophoresis of proteins is achieved in 500 seconds in a microfluidic system fabricated from PDMS, in which the first dimension of micellar electrokinetic chromatography and the second dimension of capillary sieving electrophoresis are coupled. By installing valves at the intersection of two dimensions, the separations are performed sequentially without interference.

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High Throughput Screening of Biocompatible Polymers
Guilhem A. Tourniaire, Jerome Sallette and Mark Bradley

The aim of this project was to develop high throughput screening methods using an IMSTAR Pathfinder™ High-content imaging platform to support the analyses of polymeric materials synthesised using a parallel approach. This was achieved by developing arrays of polymeric materials.

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Application of Microarrays in Process Analytical Technologies A First Step Towards Real Time Product Release
Streefland M, van de Waterbeemd B, vander Pol LA, Beuvery EC, Martens DE,Tramper J

Application of microarrays during process development helps to gain insight in biological processes involved in product formation, increasing process understanding.

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Gene Identification Through Array CGH: The CHARGE Syndrome
Lisenka Vissers, Conny van Ravenswaaij, Ronald Admiraal, Jane Hurst, Bert de Vries, Irene Janssen, Walter van der Vliet, Erik Huys, Pieter de Jong, Ben Hamel, Eric Schoenmakers, Han Brunner, Joris Veltman and Ad Geurts van Kessel.

In this study we have used high-resolution genome-wide DNA copy number screening by array-based comparative genomic hybridization (array CGH)2-3 to identify the underlying genetic cause of this malformation syndrome. Through this screening we identified overlapping microdeletions on chromosome 8 in two CHARGE patients.

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New 3D Black Substrate for Protein Microarrays with Improved Dynamic Range
Markus Hollas, Eric Jallerat, Karl Pflanz, Inka Praulich, Johanna Walter

A competitive study analysing the background fluorescence and the detectable concentration range of a chosen antigen is presented. An Affymetrix Spotting roboter 417 arrayer was used for protein dotting. The analysis is based on fluorescence scanning experiments with an Affymetrix 428 array scanner at a gain of 60. Data analysis was made with ImaGene Premium 5.5.3 by Biodiscovery Inc.

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Optimisation Workflow for the Production and Processing of High Quality Microarrays Applications in DNA, Peptide, antibody, and Carbohydrate Microarraying
Jens Sobek, Catharine Aquino and Ralph Schlapbach

We have developed a workflow for optimisation of array preparation and for processing protocols. Only 4 independent model experiments and solvent, immobilisation and blocking conditions. Optimal conditions or high quality microarray experiments were determined and used for array production and slide processing at the FGCZ.

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Diagnostic Genotyping of Drug Metabolising Enzyme Genes on Microarray: The DrugMEt™ Pharmacogenetic IVD Test
Hendolin PH, PhD, U Ristonmaa, MSc, A Liikola, MSc, P Kolu, MSc, T Varis, LabTech, A Lehtelä, LabTech. and V-P Korhonen, PhD

A microarray test for in vitro diagnostic use that contains 27 SNPs from 8 different genes with a proven role in the metabolism of major drugs and that may be processed using regular laboratory instrumentation and a range of different scanners.

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Showing Results 121 - 130 of 137
Scientific News
Tailor-Made Cancer Treatments? New Cell Culture Technique Paves The Way
Technique grew cells from 73% of patients in the study, more than three times as effective as previous methods.
Predicting Sepsis
Altered white-blood-cell motion in burn patients may warn of infection.
New Advance in Cryopreservation Could Change Management of World Blood Supplies
Engineers have identified a method to rapidly prepare frozen red blood cells for transfusions.
Stanford Engineers Discover How to Record the Forensic History of Chemical Contaminations in Water
An invention called a time capsule is a tiny chemistry lab designed to take a fingerprint of contamination and also disclose when it occurred.
Wallet-Sized Labs The Next Big Thing
RMIT researchers are developing inexpensive, portable toxicology laboratories so small you could fit them in your wallet.
Up-close Look at Cancer on the Move
Microscopic view of metastasis could give insight about how to keep cancer in check.
A Medical Lab For The Home
Fraunhofer FIT demonstrates a mobile wireless system that monitors the health of elderly people in their own homes, using miniature sensors.
Detecting Prostate Cancer With a Microfluidic Device
Innovative device detects prostate cancer, kidney disease on the spot.
Hello? Sweat and a Smartphone Could Become The Hot New Health Screening
A new article highlighting UC research reveals how sweat and microfluidics can pinpoint and help dodge potential health issues for everyone from athletes to preemies.
New 'Lab-on-a-Chip' Could Revolutionize Early Diagnosis of Cancer
Faster result times, reduced costs, minimal sample demands and better sensitivity of analysis.
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