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New Platforms and Systems for DNA Microarrays
B. Henze, B. Saal, D. Drutschmann, K. Wellesen and P. Schüßler

Operon has designed probes of different lengths to various positions in the Open Reading Frames (ORFs) and the results clearly show that 70mers offer the optimal combination of specificity and sensitivity.

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S&S® Serum Biomarker Chip Displays Specificity & Reproducibility for 120 Different Human Biomarker Profiles
Christopher C. Zarozinski, Damon W. Pawlak, Brett A. Stillman, Michael A. Harvey and Breck O. Parker

We introduce a unique tool for the determination of relative abundances for human serum biomarkers. Conceptually similar to DNA microarrays, the S&S® Serum Biomarker Chip (SBC) is a single capture antibody array that was developed for comparative analysis of serum samples in order to identify differences or similarities in protein expression profiles.

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SPR Imaging of Protein Microarrays for Detection of Antibody Binding
J.B. Beusink, G.A.J. Besselink and R.B.M. Schasfoort

In our study we have used the imaging SPR Instrument for Biomolecular Interaction Sensing (iSPR-IBIS) (IBIS Technologies BV, Hengelo, The Netherlands), for monitoring the binding of biomolecules to a protein array in a fully automated manner. A TopSpot instrument from BioFluidix GmbH (Freiburg, Germany) was used to spot the protein array.

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Fully Automatic Analysis of DNA Microarray Images
S.Mitterhuber, B.Petersch and O.Serrano

During the last years, the advent and rapid development of DNA microarray techniques has revolutionized genetic research in life sciences. We are presenting a new stand-alone software for fully automated analysis of microarray images. It employs a number of novel image processing algorithms for grid detection and spot segmentation which assure high calculation speed and accuracy.

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Design and Functional Analysis of ssDNA Directed Assembly in Protein Array
Ng Jin Kiata, Parayil Kumaran Ajikumara, Tang Yew Chunga, Lee Jim Yanga, Gregory Stephanopoulosa and Too Heng-Phona

The present poster discusses the fabrication and evaluation of a new platform called “Spatially addressable protein array” (SAPA). By exploring the specificity of DNA hybridization, ssDNA-antibody conjugates would capture the antigen from complex biological samples in milieu and spatially addressed to specific location on the oligo array for detection.

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Automated Multi-Layered Multiplex Assay Production with Inkjet Technology
Susan Seaton, Duncan Hall and Howard Manning

This work reports on the production and exact reproducible nature of the Aj120 Inkjet Microarray Spotter when printing multiple droplet microarrays. This has lead to successful collaborations between Arrayjet and a number of scientific groups furthering the use of this novel method of non-contact printing within the microarray field, a few of which are highlighted here.

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Prediction of Protein-to-Protein Interactions
C.Gilissen, P.Groot, P.Lucas, J.Veltman, A.GeurtsvanKessel and M.Egmont-Petersen

We use local extrema in microarray time series data as the basis for discretisation. By comparing discretised gene expressions using similarity functions, we discover putative protein-to-protein interactions. We validate the results by use of public true positive and true negative databases for protein-to-protein interactions and demonstrate the high predictiveness of these local extrema as a time series feature.

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Constructing Directed Metabolic Networks from Microarray Data
J. M. Easton, T. N. Arvanitis, A. Peet and M. Viant

Although it has been several years since metabolic networks became a commonly used analysis technique in bioinformatics, the question of how best to construct them from experimental data is still not satisfactorily resolved. Here we present a method for the construction of directed metabolic networks from microarray datasets using an enhanced version of the KEGG LIGAND database.

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Biosensors using Surface Plasmon Resonance Dynamic Imaging
J. Hottin, J. Spadavecchia, M. Canva, E. Maillart, M. Anger-Leroy and P. Kerourédan

We study the optical response of a SPRi detection system, characterizing temperature, stringency and time dependence of molecular interactions for the development of a DNA biochip. We are adapting this system and improve its robustness developing applications, as a 900 spots microarray identifying 65 mutations of the cystic fibrosis, for medical uses and industrial commercialization.

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Showing Results 121 - 130 of 153
Scientific News
Detecting Cryptosporidium in China
A recently developed lab-on-a-chip device, which can diagnose the opportunistic parasite in as little as 10 minutes, may help improve treatment in remote, at-risk rural areas.
Detecting Low-Quality Antimalarial Drugs With A Lab-On-Paper
Lab-on-Paper can detect low-quality anitmalarial drugs without expensive equipment.
Measuring Volumes of Key 'Lab on a Chip' Components
NIST found a combination of techniques to effectively measure microfluidic channels, achieving an accuracy of within 5 percent for both a channel's depth and its bottom's width.
Superior Ability To Rapidly Detect Volatile Organic Compounds
Researchers develop a credit-card-sized gas chromatography platform that can analyze volatile compounds within seconds.
Breath Test For Detecting Head And Neck Cancer
A portable device can detect the presence of certain types of cancer in people's breath.
Characterizing the Micro-Mechanical Properties of Soft Materials, Tissues and Cells
Ernst Breel of Optics11 discusses the current problems with characterizing the mechanical properties of soft materials, focusing on how the company's Piuma Nanoindenter can assist researchers.
Using Sound Waves To Detect Rare Cancer Cells
Acoustic device can rapidly isolate circulating tumor cells from patient blood samples.
Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
Dartmouth researchers and bioengineers develop novel system to improve cancer treatment.
Mechanically Stimulating Stem Cells
MIT biological engineering graduate student Frances Liu is studying ways to alter mechanical properties of cell environments to produce desired chemical outputs.
Catching And Releasing Tiny Molecules
New technique for sorting biomolecules could lead to efficient clinical diagnostics and chemical purification.
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