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Nanoliter Volume Pin Tool Transfers as Measured by a Dual-Dye Absorbance Method
Duong T. Chau; Patrick H. Cleveland, Ph.D. (V & P Scientific); John Thomas Bradshaw, Ph.D. (ARTEL)

This poster compares the volumes of sample solutions delivered by an array of stainless steel and hydrophobic-coated pins as measured by a fluorescent-dye approach versus a dual-dye absorbance approach.

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SFC Fluidics Microfluidic ePump Technology Ideal for Point of Care Diagnostics
Forrest Payne Champak Das and Guochun Wang

True Point of Care medical devices place unique demand on micropump characteristics. SFC Fluidics ePump is an innovative electrochemical pumping system that is different from other microfluidic pumps.

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Magnetohydrodynamic Based Circular Liquid Chromatography On Chip
Champak Das Guochun Wang and Forrest Payne

This poster demonstrates cyclic liquid chromatography on chip and shows how this can be used in other closed loop applications.

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Novel Valve Designs in a Completely Sealed Microfluidic System
Guochun Wang

Two one time use valve strategies have been successfully demonstrated in a completely sealed assay chip. They were also shown to be feasible for on chip reagent storage.

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Electrochemical Microfluidic Biosensor for E.coli Detection
Mohammadali Safavieh, Minhaz Uddin Ahmed, and Mohammed Zourob

Microfluidic electrochemical biosensor based on Loop-mediated Isothermal Amplification (LAMP) was developed for detection and quantification of E.coli. The electrochemical detection was achieved using Hoechst 33258 redox molecule and linear sweep voltametry (LSV). Here, we detect and quantify 48 CFU/ml of bacteria in 35 min in LB media and urine samples. This microfluidic chip has great potential to be used as a point of care diagnostic (POC) device for clinical application.

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Aptamer-based protein biochip with a SPAD array time-resolved detection
L. Pasquardini1, L. Pancheri1, E. Morganti1, L. Lunelli1, C. Collini1, L. Lorenzelli1, D. Stoppa1, E. Buselli2, A. Menciassi2, C. Pederzolli1

In this work a silicon biochip based on a matrix of transparent micro-reactor sites coupled with a linear SPAD (Single-Photon Avalanche Diode) detector array for detecting traces of proteins in biological fluids is presented. A microfluidic layer of PDMS containing a peristaltic pump was implemented. The biofunctional layer for the detection of target proteins is based on a dual-site binding strategy employing DNA aptamers.

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Optical Microchip Sensors for Multiplexed Detection of Biological Pathogens
D. Bhatta, A. Michel, M. Marti Villalba, G. D. Emmerson, I. J. G Sparrow, M. B. McDonnell, E. A. Perkins , R. W. Ely and G. A. Cartwright

SpectroSens, a multi-channel optical microchip sensor system suitable for rapid, label-free multiplexed detection of a wide range of bio-hazardous agents is presented. Optical chips containing multiple high-precision planar Bragg gratings are exploited as low-cost, robust refractive index sensors.

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Low cost direct optical structuring of lab-on-a-chip devices using stamps photopolymer
German Comina, Jose Solis, Walter Estrada

In this work the development of microfluidics devices using a simple, fast and low cost fabrication method is shown. The devices were made using a photopolymer designed for making stamps. The obtained results make this concept a convenient technology for configuring compact service areas of specialized microfluidic and detection microstructures compatible with autonomous LOC devices.

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On chip micro-extraction and real-time PCR with integrated SPAD optical fluorescence detection for nucleic acid analysis
Cristina Potrich, Elisa Morganti, Nicola Massari, Lucio Pancher, C. Kostoulas, Laura Pasquardini, Cristian Collini, Andrea Adami, Lorenzo Lunelli, F. Kalatzis, David Stoppa, Cecilia Pederzolli, Leandro Lorenzelli

A PDMS lab-on-a-chip for one step DNA isolation and real time-polymerase chain reaction (RT-PCR) has been designed, fabricated, and characterized for point-of-care clinical diagnostics. In addition, a module for on-chip optical detection based on SPAD - Single-Photon Avalanche Diode - detector has also been developed and used to monitor the presence of specific DNA polymorphisms possibly related to genetic diseases.

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Showing Results 41 - 50 of 149
Scientific News
Mechanically Stimulating Stem Cells
MIT biological engineering graduate student Frances Liu is studying ways to alter mechanical properties of cell environments to produce desired chemical outputs.
Catching And Releasing Tiny Molecules
New technique for sorting biomolecules could lead to efficient clinical diagnostics and chemical purification.
A Single-Cell Breakthrough
UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.
Tiny Optical Antennas: A Nano Revolution
Newly developed tiny optical antennas, which function like spotlights at the nanoscale, offer the potential to measure food safety, identify air pollutants and even quickly diagnose and treat deadly diseases, like cancer.
Solving The Mystery Of The Dancing Droplets
Years of research satisfy a graduate student's curiosity about the molecular minuet he observed among drops of ordinary food coloring.
Hearts On A Chip To Aid Drug Screening
UC Berkeley bioengineers have developed a heart-on-a-chip which can be used for drug safety screening.
Lab-On-Paper Invented
New paper-based platform for conducting a wide range of complex medical diagnostics.
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Lab-on-a-Chip to Study Single Cells
Scientists at EPFL have developed a new lab-on-a-chip technique to analyze single cells from entire population. The new method, which uses beads and microfluidics can change the way we study mixed populations of cells, such as those of tumors.
Mini Synthetic Organism Instead Of Test Animals
Using a compact multi-organ chip, and those of three separate microcircuits, researchers can study the regeneration of certain kidney cells.
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