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Controlled Synthesis and Manipulation of Self-Assembled Peptide Nano Spheres by Microfluidic Dielectrophoresis (DEP)
Nikolaj O. Christiansen, Mohammad Ajine, Jaime Castillo, Maria Dimaki & Winnie E. Svendsen

The self-assembled peptides as building blocks are excellent candidates for applications in biomedical nanotechnology because of their chemical diversity, flexibility, biocompatibility and stability. This work shows a stable synthesis in liquid and that is's posible to manipulate them using positive DEP.

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A Platform to Study Platelet Aggregation and Thrombus Growth Based on Dynamic Stress
F. J. Tovar-Lopeza1, G. Rosengarten2, K. Khoshmanesh3 , E. Westein4 , S. P. Jackson4, Arnan Mitchell 1, and W. S. Nesbitt4

We present a microfluidic device that is able to trigger initial recruitment and subsequent aggregation of discoid platelets by mimicking the effects of pathological changes in blood vessel geometry.

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Development of a Fully Integrated Microfluidic Device for Electromodulated Liquid Chromatography with C4D Detection
Jeremy Galineau, Blanaid White, Aoife Morrin, Malcolm R. Smyth

Applications for microfluidic technologies in life science are expanding rapidly, and have the potential to impact enormously across a range of fields, from cell manipulation to separation science. In separation science their small channel dimensions make them ideal for high throughput separations, reducing sample volumes and solvent consumption.

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A Practical Microfluidic Device for Synthesis of Purified Monodisperse Micro-Alginate Beads (MABs) as Microcarriers of Gold Nanoparticles.
Paul-Emile POLENI, Serge OSTROVIDOV, Yasuyuki SAKAI and Teruo FUJII

We developed a microfluidic device for encapsulating gold nanoparticles in Micro-Alginate Beads (MABs). The size and the gap of the monodisperse alginate droplets were successfully controlled by adjusting the relative "oil/sample" flow rate ratio. Droplets reacted with calcium ion at the interface between oil phase and aqueous phase so that MABs precipitated spontaneously and undergone complete gelation. Purified MABs were successfully observed by fluorescence microscopy.

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ON CHIP PROTEIN DYNAMICS IN SINGLE BACTERIA CELLS WITH SPATIO-TEMPORAL RESOLUTION
Dominik Greif, Nataliya Pobigaylo, Anke Becker, Jan Regtmeier and Dario Anselmetti

We demonstrate spatio-temporal protein dynamics in single living bacterial cells from time lapse fluorescence imaging (TLFI) in a microfluidic chip.

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Integration of predictive model with microfluidics fabrication using a 193 nm excimer laser source shaped by an Intelligent Pinhole mask
Kevin Conlisk and G.M. O'Connor

Simulation, analysis and fabrication of microfluidic geometries using a laser-based fabrication process incorporating a reconfigurable mask. A LabVIEW development programme provides geometrical analysis prior to fabrication. The same programme is then used to control the mask during the machining step.

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Multifunctional, “Smart”, Polymeric Microfluidics Fabricated by Plasma Processing: Applications in Capillary Filling, and Passive Superhydrophobic Valving
Katerina Tsougeni, Dimitris Papageorgiou, Angeliki Tserepi and Evangelos Gogolides*

We demonstrate a mass-production amenable technology for fabrication, surface modification and multifunction integration in plastic, disposable microfluidic devices, namely direct lithography on the plastic substrate followed by polymer plasma etching, and if desired by selective plasma deposition. We apply the plasma processing technology to fabricate polymeric microfluidics in Poly(methyl methacrylate) (PMMA) and Poly(ether ether ketone) (PEEK). Our approach proposes “smart” multifunctional mi

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In-plane detection of fluorescence signals in microfludic lab-on-chip flow cytyometry
James Hoyland, Casper Kunstmann-Olsen

Several means of extracting fluorescence signals from flowing cell suspensions in a single plane are examined. Simple microfluidic flow cytometer structures incorporating lateral hydrodynamic focusing were molded in PDMS. Several geometries for embedding optical fibers and custom molded waveguides into the same structure were compared. Improvement in light yield is examined with molded cylindrical lenses and by using channels filled with high refractive index polymers as waveguides.

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Gene List Significance Index (GLSI) improves our method High Performance Chip Data Analysis dramatically - Quantifying the quality of different lists of analyzed significant genes
Joachim R. Grün (1), Andreas Grützkau (1), Marta Steinbrich-Zöllner (3) Thomas Häupl (2), Ria Baumgrass (1), Jochen Sieper (3), Gerd-Rüdiger Burmester (2), Andreas Radbruch (1)

Our gene expression profiling strategy High Performance Chip Data Analysis (HPCDA) was improved with a method for quantifying the quality of different gene lists (GLs) with the new Gene List Significance Index (GLSI). With GLSI it is possible to decide which of two different extracted GLs has highest fraction of true positives, of high fold change or low p-value genes. With GLSI we could empirically optimize HPCDA-Score for ranking genes.

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Showing Results 61 - 70 of 150
Scientific News
Mechanically Stimulating Stem Cells
MIT biological engineering graduate student Frances Liu is studying ways to alter mechanical properties of cell environments to produce desired chemical outputs.
Catching And Releasing Tiny Molecules
New technique for sorting biomolecules could lead to efficient clinical diagnostics and chemical purification.
A Single-Cell Breakthrough
UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.
Tiny Optical Antennas: A Nano Revolution
Newly developed tiny optical antennas, which function like spotlights at the nanoscale, offer the potential to measure food safety, identify air pollutants and even quickly diagnose and treat deadly diseases, like cancer.
Solving The Mystery Of The Dancing Droplets
Years of research satisfy a graduate student's curiosity about the molecular minuet he observed among drops of ordinary food coloring.
Hearts On A Chip To Aid Drug Screening
UC Berkeley bioengineers have developed a heart-on-a-chip which can be used for drug safety screening.
Lab-On-Paper Invented
New paper-based platform for conducting a wide range of complex medical diagnostics.
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Lab-on-a-Chip to Study Single Cells
Scientists at EPFL have developed a new lab-on-a-chip technique to analyze single cells from entire population. The new method, which uses beads and microfluidics can change the way we study mixed populations of cells, such as those of tumors.
Mini Synthetic Organism Instead Of Test Animals
Using a compact multi-organ chip, and those of three separate microcircuits, researchers can study the regeneration of certain kidney cells.
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