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System-level Simulation of Liquid Filling in Microfluidic Chips
Hongjun Song, Yi Wang, and Kapil Pant

The overall objective of our work is to develop a system-level model and simulation framework for investigating the liquid filling process (including the filling time, filling pattern/status, flow velocity/pressure etc.) in complex microfluidic networks with order-of-magnitude speedup over the high-fidelity simulations and without appreciably compromising analysis accuracy.

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EXPERIMENTAL CHARACTERIZATION OF A METHOD TO REVERSIBLY BOND MICROFLUIDIC DEVICES THROUGH MAGNETIC FORCES
Francesco Piraino, Matteo Moretti, Alberto Redaelli, Marco Rasponi

A method based on magnetic forces to reversibly bond glass slides to PDMS microfluidic devices has been developed and experimentally characterized. Results show a reliable tightness in normal laboratory applications.

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Pressure Driven HepG2 cells Focusing on a Microchip
Paul-Emile POLENI, Olivier DUCLOUX, Serge OSTROVIDOV, Hiroyuki FUJITA, Teruo FUJII

We present a pressure driven microfluidic system devoted to concentration of cells in localized clusters ready for 3D cell culture in a microchamber. Cells are flown back and forth into the microchamber by pressurization/de-pressurization of two air caps symmetrically placed at two ends of a microchannel. The symmetry of the flow induces the presence of a dead volume in the cell culture chamber, favouring a rapid cell trapping and aggregation.

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Controlled Synthesis and Manipulation of Self-Assembled Peptide Nano Spheres by Microfluidic Dielectrophoresis (DEP)
Nikolaj O. Christiansen, Mohammad Ajine, Jaime Castillo, Maria Dimaki & Winnie E. Svendsen

The self-assembled peptides as building blocks are excellent candidates for applications in biomedical nanotechnology because of their chemical diversity, flexibility, biocompatibility and stability. This work shows a stable synthesis in liquid and that is's posible to manipulate them using positive DEP.

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A Platform to Study Platelet Aggregation and Thrombus Growth Based on Dynamic Stress
F. J. Tovar-Lopeza1, G. Rosengarten2, K. Khoshmanesh3 , E. Westein4 , S. P. Jackson4, Arnan Mitchell 1, and W. S. Nesbitt4

We present a microfluidic device that is able to trigger initial recruitment and subsequent aggregation of discoid platelets by mimicking the effects of pathological changes in blood vessel geometry.

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Development of a Fully Integrated Microfluidic Device for Electromodulated Liquid Chromatography with C4D Detection
Jeremy Galineau, Blanaid White, Aoife Morrin, Malcolm R. Smyth

Applications for microfluidic technologies in life science are expanding rapidly, and have the potential to impact enormously across a range of fields, from cell manipulation to separation science. In separation science their small channel dimensions make them ideal for high throughput separations, reducing sample volumes and solvent consumption.

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A Practical Microfluidic Device for Synthesis of Purified Monodisperse Micro-Alginate Beads (MABs) as Microcarriers of Gold Nanoparticles.
Paul-Emile POLENI, Serge OSTROVIDOV, Yasuyuki SAKAI and Teruo FUJII

We developed a microfluidic device for encapsulating gold nanoparticles in Micro-Alginate Beads (MABs). The size and the gap of the monodisperse alginate droplets were successfully controlled by adjusting the relative "oil/sample" flow rate ratio. Droplets reacted with calcium ion at the interface between oil phase and aqueous phase so that MABs precipitated spontaneously and undergone complete gelation. Purified MABs were successfully observed by fluorescence microscopy.

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ON CHIP PROTEIN DYNAMICS IN SINGLE BACTERIA CELLS WITH SPATIO-TEMPORAL RESOLUTION
Dominik Greif, Nataliya Pobigaylo, Anke Becker, Jan Regtmeier and Dario Anselmetti

We demonstrate spatio-temporal protein dynamics in single living bacterial cells from time lapse fluorescence imaging (TLFI) in a microfluidic chip.

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Integration of predictive model with microfluidics fabrication using a 193 nm excimer laser source shaped by an Intelligent Pinhole mask
Kevin Conlisk and G.M. O'Connor

Simulation, analysis and fabrication of microfluidic geometries using a laser-based fabrication process incorporating a reconfigurable mask. A LabVIEW development programme provides geometrical analysis prior to fabrication. The same programme is then used to control the mask during the machining step.

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Showing Results 61 - 70 of 153
Scientific News
First Liquid Nanolaser Developed
Technology could lead to new way of doing ‘lab on a chip’ medical diagnostics.
Tiny Lab Devices Could Attack Huge Problem of Drug-Resistant Infections
NIH-funded project aims for fast identification and destruction of deadly bacteria.
Detecting Cryptosporidium in China
A recently developed lab-on-a-chip device, which can diagnose the opportunistic parasite in as little as 10 minutes, may help improve treatment in remote, at-risk rural areas.
Detecting Low-Quality Antimalarial Drugs With A Lab-On-Paper
Lab-on-Paper can detect low-quality anitmalarial drugs without expensive equipment.
Measuring Volumes of Key 'Lab on a Chip' Components
NIST found a combination of techniques to effectively measure microfluidic channels, achieving an accuracy of within 5 percent for both a channel's depth and its bottom's width.
Superior Ability To Rapidly Detect Volatile Organic Compounds
Researchers develop a credit-card-sized gas chromatography platform that can analyze volatile compounds within seconds.
Breath Test For Detecting Head And Neck Cancer
A portable device can detect the presence of certain types of cancer in people's breath.
Characterizing the Micro-Mechanical Properties of Soft Materials, Tissues and Cells
Ernst Breel of Optics11 discusses the current problems with characterizing the mechanical properties of soft materials, focusing on how the company's Piuma Nanoindenter can assist researchers.
Using Sound Waves To Detect Rare Cancer Cells
Acoustic device can rapidly isolate circulating tumor cells from patient blood samples.
Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
Dartmouth researchers and bioengineers develop novel system to improve cancer treatment.
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