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Tuesday, December 23, 2014
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New Microarray Substrate for Fluorescent Signal Enhancement
Wayne Moore, Svetlana I. Novikova, David Moore, Lisa Jolin and Cindy Smith.

Microcosm BioBright slides (patent pending) are designed as a plug-and-play alternative to commercially available microarray substrates for use with different microarray platforms (oligo, miRNA or protein).

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Interactive Transcription Maps Over Microarray Data
Petr Krontorad, Irena Koutna and Michal Strehovsky

For final description of microarray experiment results it is necessary to use some statistically robust method. Transcription maps (TM) are used to map results of gene expression analysis into individual chromosomes. We have implemented graphical tool for interactive display of TMs. This tool allows displaying of arbitrary information for each gene.

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Expression Profiling of CD34+ of Peripheral Blood of Patients with Lymphoma During ex vivo Granulocytic Differentiation
Irena Koutna, Lenka Tesarova, Martin Klabusay, Petr Krontorad, Michal Strehovsky, Martina Peterkova and Viera Hrabcakova

On the basis of global expression data analysis we have concluded that population of CD34+ cells from patients with lymphoma shows different expression status during ex-vivo differentiation. And thus we assume that CD34+ population is not suitable for autologous transplantation. We have used cDNA microarrays technology to obtained precise expression profiles.

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Caveolin-1 Expression as a Possible Biomarker in Pancreatic Cancer Diagnosis
C. Tanase, E. Raducan, L. Albulescu, E. Codorean, M.I. Nicolescu, D.I. Popescu, M.L. Cruceru and A.C. Popa

Caveolin1 (Cav-1) function either as a tumor supressor or as a promoter of metastasis. Overexpresion of cav-1 was correlated with: tumoral grading, proliferration markers (Ki67, p53), serum tumor markers (CEA, CA19.9) and angiogenic markers (VEGF, bFGF).

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Lab-on-a-chip Biomolecular Interaction Measurement System with Integrated Microfluidics and Surface Plasmon Resonance Imaging
Ganeshram Krishnamoorthy, E.T. Carlen, S. Schlautmann, H.L. de Boer, A. Van den Berg and R. B. M. Schasfoort

We present a novel lab-on-a-chip approach for the measurement of the biomolecular interaction of a common model system (IgG – Anti IgG) using a commercial SPR imaging system (IBIS-iSPR, IBIS Technologies b.v., Hengelo, the Netherlands).

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A Novel Miniaturized Cell Lysis Device Using Spherically Focused Ultrasound
Gang Li, Hong Xiao, Min Guo and Jing Cheng

A prototype of miniaturized cell lysis device has been developed using a spherically concave transducer, which is capable of lysing bacteria in absence of added chemical denaturants or enzymes and lysing yeast efficiently without any mechanical or enzymatic pretreatment.

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A Sandwich-Injection Method for Microchip Electrophoresis
Gang Li, Gui-Sheng Zhuang, Hai-Bin Zhu, Hui-Qing Jin and Jian-Long Zhao

We present a sandwich-injection method for controlling discrete sample injection in µ-CE. This method involves four accessory arm channels in which symmetrical potentials are loaded to form a unique parallel electric field distribution to confine the spreading of sample plugs and prevent sample leakage. The virtues of the novel injection technique were demonstrated with numerical models and experiments.

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Large-scale Microarray Analysis of Protein and mRNA Level Changes in HL-60 Cells
Pavel Simara, Irena Koutna, Stanislav Stejskal, Martina Peterkova, Petr Krontorad, Zdenek Rucka

In this study we compare methods for large-scale microarray analysis of protein and RNA level changes in HL-60 cells, responding to differentiation stimuli. Using microarrays we have found, that level of several proteins was either up- or down-regulated after cell differentiation. In some cases there was significant correlation with appropriate genes.

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Preliminary Report: The Geriatric Propamed Study: Prospective pharmacopgenetics in geriatrics
Dr LS Griffith, Dr L Chialda and Dr A Pahl

In a worldwide first proscpective phamacogenetic study preliminary results show reduction of adverse drug reactions and hospitilisation stays for geriatric patients after pharmacogenetic testing and medication interaction analysis to fit the medicine to the patient.

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Showing Results 81 - 90 of 137
Scientific News
Tailor-Made Cancer Treatments? New Cell Culture Technique Paves The Way
Technique grew cells from 73% of patients in the study, more than three times as effective as previous methods.
Predicting Sepsis
Altered white-blood-cell motion in burn patients may warn of infection.
New Advance in Cryopreservation Could Change Management of World Blood Supplies
Engineers have identified a method to rapidly prepare frozen red blood cells for transfusions.
Stanford Engineers Discover How to Record the Forensic History of Chemical Contaminations in Water
An invention called a time capsule is a tiny chemistry lab designed to take a fingerprint of contamination and also disclose when it occurred.
Wallet-Sized Labs The Next Big Thing
RMIT researchers are developing inexpensive, portable toxicology laboratories so small you could fit them in your wallet.
Up-close Look at Cancer on the Move
Microscopic view of metastasis could give insight about how to keep cancer in check.
A Medical Lab For The Home
Fraunhofer FIT demonstrates a mobile wireless system that monitors the health of elderly people in their own homes, using miniature sensors.
Detecting Prostate Cancer With a Microfluidic Device
Innovative device detects prostate cancer, kidney disease on the spot.
Hello? Sweat and a Smartphone Could Become The Hot New Health Screening
A new article highlighting UC research reveals how sweat and microfluidics can pinpoint and help dodge potential health issues for everyone from athletes to preemies.
New 'Lab-on-a-Chip' Could Revolutionize Early Diagnosis of Cancer
Faster result times, reduced costs, minimal sample demands and better sensitivity of analysis.
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