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Saturday, October 25, 2014
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Caveolin-1 Expression as a Possible Biomarker in Pancreatic Cancer Diagnosis
C. Tanase, E. Raducan, L. Albulescu, E. Codorean, M.I. Nicolescu, D.I. Popescu, M.L. Cruceru and A.C. Popa

Caveolin1 (Cav-1) function either as a tumor supressor or as a promoter of metastasis. Overexpresion of cav-1 was correlated with: tumoral grading, proliferration markers (Ki67, p53), serum tumor markers (CEA, CA19.9) and angiogenic markers (VEGF, bFGF).

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Lab-on-a-chip Biomolecular Interaction Measurement System with Integrated Microfluidics and Surface Plasmon Resonance Imaging
Ganeshram Krishnamoorthy, E.T. Carlen, S. Schlautmann, H.L. de Boer, A. Van den Berg and R. B. M. Schasfoort

We present a novel lab-on-a-chip approach for the measurement of the biomolecular interaction of a common model system (IgG – Anti IgG) using a commercial SPR imaging system (IBIS-iSPR, IBIS Technologies b.v., Hengelo, the Netherlands).

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A Novel Miniaturized Cell Lysis Device Using Spherically Focused Ultrasound
Gang Li, Hong Xiao, Min Guo and Jing Cheng

A prototype of miniaturized cell lysis device has been developed using a spherically concave transducer, which is capable of lysing bacteria in absence of added chemical denaturants or enzymes and lysing yeast efficiently without any mechanical or enzymatic pretreatment.

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A Sandwich-Injection Method for Microchip Electrophoresis
Gang Li, Gui-Sheng Zhuang, Hai-Bin Zhu, Hui-Qing Jin and Jian-Long Zhao

We present a sandwich-injection method for controlling discrete sample injection in µ-CE. This method involves four accessory arm channels in which symmetrical potentials are loaded to form a unique parallel electric field distribution to confine the spreading of sample plugs and prevent sample leakage. The virtues of the novel injection technique were demonstrated with numerical models and experiments.

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Large-scale Microarray Analysis of Protein and mRNA Level Changes in HL-60 Cells
Pavel Simara, Irena Koutna, Stanislav Stejskal, Martina Peterkova, Petr Krontorad, Zdenek Rucka

In this study we compare methods for large-scale microarray analysis of protein and RNA level changes in HL-60 cells, responding to differentiation stimuli. Using microarrays we have found, that level of several proteins was either up- or down-regulated after cell differentiation. In some cases there was significant correlation with appropriate genes.

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Preliminary Report: The Geriatric Propamed Study: Prospective pharmacopgenetics in geriatrics
Dr LS Griffith, Dr L Chialda and Dr A Pahl

In a worldwide first proscpective phamacogenetic study preliminary results show reduction of adverse drug reactions and hospitilisation stays for geriatric patients after pharmacogenetic testing and medication interaction analysis to fit the medicine to the patient.

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Microfluidic Platform for Point-of-Care Blood Typing
B. Scheufele, R. Gronmaier, J. Claussen, S. Haeberle, J. Kohnle, J. Ducree, R. Zengerle, H. Northoff and F.K. Gehring

We have developed a microfluidic platform for mass sensitive analysis of whole blood that allows fast and reliable Point-of-Care blood typing of the AB0 system requiring small sample volumes. Potential application areas of the microfluidic platform include emergency medical aid, clinics and doctor's surgeries.

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Development of a Lab-on-a-Chip for the Characterization of Human Cells
Richter, L., Stepper, C., Mak, A., Brückl, H. and Ertl, P.

Cell chips are developed to continuously monitor mammalian cell population dynamics in a non-invasive manner. In the presented work we describe the design, fabrication and characterization of a lab-on-a-chip for quantitative cell analysis.

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Label-free Identification of Microorganisms using a Contact-less Dielectric Microsensor
Ertl, P., Richter, L., Reinthaler, A., Stepper, C., Mak, A., Kast, M., Heer, R. and Brückl, H.

Microfabricated biochips are developed to continuously monitor cell population dynamics in a non-invasive manner. In the presented work we describe the novel combination of contact-less dielectric microsensors and microfluidics to promote biofilm formation for quantitative cell analysis.

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Showing Results 81 - 90 of 134
Scientific News
New 'Lab-on-a-Chip' Could Revolutionize Early Diagnosis of Cancer
Faster result times, reduced costs, minimal sample demands and better sensitivity of analysis.
How Fluid Flow Influences Neuron Growth
A University of Texas at Arlington team exploring how neuron growth can be controlled in the lab and, possibly, in the human body has published a new paper in Nature Scientific Reports on how fluid flow could play a significant role.
‘Tissue Chip’ to Screen Neurological Toxins
UW-Madison team are developing a faster, more affordable way to screen for neural toxins.
Modular Components Make Building 3-D “Labs-on-a-Chip” a Snap
New building blocks take microfluidics from flat to 3-D quickly and easily.
NIH Funds Next Phase of Tissue Chip for Drug Screening Program
Scientists will integrate chips mimicking human organ functions into full body system to evaluate drugs.
Airway Muscle-On-A-Chip Mimics Asthma
Tissue-level model of human airway musculature could pave way for patient-specific asthma treatments.
New Chip Promising For Tumor-Targeting Research
The new system, called a tumor-microenvironment-on-chip device, will allow researchers to study the complex environment surrounding tumors and the barriers that prevent the targeted delivery of therapeutic agents.
Gene Expression Patterns in Pancreatic CTCs Revealed
Distinct patterns of gene expression in several groups of CTCs were identified, including significant differences from the primary tumor that may contribute to the ability to generate metastases and prove to be targets for improved treatment of the deadly tumor.
Blood Cleanser for Sepsis
Dialysis-like ‘biospleen’ quickly filters bacteria, fungi and toxins.
Stanford Engineers Aim to Connect the World with Ant-sized Radios
Costing just pennies to make, tiny radios-on-a-chip are designed to serve as controllers or sensors for the 'Internet of Things.'
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