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Featured Products
Featured Product - AxION DSA System
AxION DSA System

Webcasts
Webcast - Streamlining Routine Chromatography Analyses using eWorkflows Streamlining Routine Chromatography Analyses using eWorkflows
Darren Barrington-Light, Product Specialist, Thermo Scientific
Webcast - Towards an Exosomes-based Molecular Test for Remission Monitoring of CancerTowards an Exosomes-based Molecular Test for Remission Monitoring of Cancer
Michiel Pegtel, VU University Medical Center, speaking at Molecular Medicine Congress 2013.

Market Reports
Mass Spectrometry for Clinical Diagnostics Applications 2013 Focus Report
SELECTBIO

This report from SELECTBIO addresses a number of topics including, market segmentation, market landscape, and mass spectrometry products currently on the market as well as in development.
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Mass Spectrometry 2013: A Focus on Sales Growth
Biopharm Reports

Mass Spectrometry 2013 presents the findings of a global market study of mass spectrometry, involving the participation of 567 buyers and end-users in this field. With a focus on market development, sales growth and commercial opportunities, the study profiled current and evolving areas of this market, as outlined below. Its findings provide valuable product and market information, and decision-making support to suppliers in the mass spectrometry field.
Mass-Spec Based Screening Assay Trends 2013
HTStec

This market report summarizes the results of HTStec's 1st industry-wide global web-based benchmarking survey on mass spectrometry (MS)-based screening assays carried out in February 2013.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights

Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights

There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Scientific News
A Metabolomic Perspective on Coeliac Disease
Metabolomics has proved to be a useful complement for the characterization of several physiological and pathological conditions and offers promises as a clinical tool.
Some Long Non-Coding RNAs Are Conventional After All
Researchers have used ribosome profiling to identify several hundred long non-coding RNAs that may give rise to small peptides.
Thousand Times Sensitivity Increase for Doping Drugs Testing
Method developed by UT Arlington researchers can be up to 1,000 times more sensitive than many current tests.
Development and Validation of LC/MS/MS Method and its Application to a Pharmacokinetic Study
Researchers aimed to develop a LC/MS/MS method to monitor plasma levels of montelukast, gliclazide, and nifedipine for application in pharmacokinetic studies and routine clinical practice.
Monitoring and Risk Assessment of Pesticide Residues in Commercially Dried Vegetables
The study aimed to analyze the presence of 253 pesticides commonly used on dried vegetables and to check their compliance with existing regulations.
Evaluation of Thermally Degraded Vegetable Oils using FTIR and GCMS
Researchers report a synchronised signal processing algorithm that caters both FTIR and GCMS signal for evaluation of thermally degraded vegetable oils.
The Role of Mass Spectrometry in the "Omics" Era
The tremendous developments of the MS technology and concurrent gene sequencing efforts have made the “-omic” revolution possible.
Halal Meat Authenticity Testing Reassures Consumers of No Pig or Horse Contamination
New LC/MS/MS-based meat speciation method allows food testing laboratories to detect pig and horse contamination in diverse food products, with higher accuracy than existing methods.
Metabolomics Reveals a Role for the Chromatin-Binding Protein HMGN5 in Glutathione Metabolism
This study links the expression of HMGN5 to transcriptional changes that affect glutathione metabolism in the liver.
Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS
Mass spectrometry has been successfully applied for the identification and quantification of uremic toxins.
Business News
Canada Invests $30.4M in University Research Infrastructure
The funding at 32 universities was announced by Ed Holder, Minister of State (Science and Technology).
Pittcon Announces Recipients of the Editors’ Awards
Recipients include Texas Instruments (Gold), Waters (Silver) and ABSciex (Bronze).
Agilux Laboratories Appoints Head of GLP Bioanalysis
Dr LeLacheur appointed Head of GLP Bioanalysis for Agilux's pharmaceutical development services.
Cedars-Sinai Names Director of Advanced Clinical Biosystems Research Institute
Prominent proteomic and cardiac scientist Jennifer Van Eyk, PhD, has been named the inaugural director of Cedars-Sinai's Advanced Clinical Biosystems Research Institute.
Shimadzu Registers HPLC and LCMS Instruments as Class I Medical Devices with FDA
Products are the first Shimadzu analytical instruments registered with the FDA as medical devices.
Industry-Sponsored Academic Inventions Spur Increased Innovation
Analysis questions assumption that corporate support skews science toward inventions that are less useful than those funded by the government or non-profit organizations.
Spyglass, SRI to Commercialize Underwater Mass Spectrometer
Licensing agreement extends availability of SRI MIMS technology for oil and gas exploration, marine research, and other monitoring and detection applications.
Thermo, Harvard Establish Center for Multiplexed Proteomics
Thermo Fisher Scientific Center for Multiplexed Proteomics at Harvard Medical School aims to expedite understanding of complex disease mechanisms.
Agilent Supports NUS-Led Research Consortium to Identify, Map Lipid Levels in Healthy People
New international effort to develop world's first integrated systems biology database for different races and ethnicities.
EquipNet to Discuss Asset Management Systems at Interphex 2014
Visit EquipNet on Booth #1239.

Events
BIT
25 Apr 2014
BIT's 3rd Annual Conference an ...
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CMC Strategy Forum Europe 2014
05 May 2014
CMC Strategy Forum Europe 2014 ...
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HPLC 2014
11 May 2014
HPLC 2014 ...
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62nd ASMS Conference on Mass S
15 Jun 2014
62nd ASMS Conference on Mass S ...
More information

ePosters
GC-MS Comparison of Lavindin Grosso Oil Obtained by Steam Distillation and SFE
Miami University Middletown

Oil was extracted from Lavindin Grosso using steam distillation and using supercritical fluid extraction (SFE). Multiple analyses of the same extract demonstrated repeatability of the analytical method. The variability between batches of distillate bracketed the composition obtained by SFE. The differences among the oils could be attributed more to where the lavender was grown than to the extraction method.
A multianalyte algorithm PCR-based blood test outperforms single analyte ELISA-based blood tests for neuroendocrine tumor detection
Wren Laboratories

In a prospective study, in age-/sex- and ethnicity-matched patients and controls (n=82), a 51 panel multigene blood transcript test (NETest) was identified to be significantly more sensitive and accurate (>93%) than any single analyte assay (Chromogranin A, Pancreastatin or Neurokinin A) for neuroendocrine tumor detection.
Purification of Synthetic Oligodeoxynucleotides via Catching by Polymerization
Michigan Technological University

This poster describes new simple methods for oligodeoxynucleotide purification without chromotography.
Identification and classification of antifouling compounds secreted by anti MIC microorganisms. A metabolomic analysis.
University of Burgos, INBIOTEC, CSIC and ACCIONA Infraestructuras, Spain

BIOCORIN project, aims to develop a green alternative to the coatings and solutions used up to date for MIC corrosion control. Some of the results of this project are presented here, with the identification of several relevant antifouling compounds secreted by environmentally isolated anti-MIC strains of microorganisms via a metabolomic approach.
Chemometrical optimization and fast determination of debittering of table olives by means of capillary electrophoresis
Univesity of Burgos, Spain

Table olives require a thorough process of debittering in order to achieve the organoleptic quality of olives before consumption. Capillary electrophoresis offers several advantages to the determination of the bitter responsible compound oleuropein in table olives, such as speed, reduced amount of solvents and reagents, small amount of sample, high efficiency and lower costs.
Rapid Identification of Microorganisms by Touch Spray and Paper Spray Ambient Ionization
Purdue University

The rapid and accurate identification of microorganisms is necessary in order to improve public health. Molecular-based identification allows for rapid patient treatment and provides more accurate diagnoses, two crucial aspects for successful treatment, yet a great challenge. In this work PS-MS, an existing ambient method, and TS-MS, a newly developed technique, are being utilized in the rapid discrimination of microorganisms (<2 min).
Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
Denator AB

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.
Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
Denator AB

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.
Processing and Managing Analytical Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.

This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
UPLC-MS/MS for the Screening, Confirmation and Quantification of 32 Drugs Illegally Added to Herbal/Dietary Supplements for the Enhancement of Male Sexual Performance
Supreme Council of Health, Qatar

This poster outlines development of a novel screening method that is suitable for both the detection of known and unknown ED drugs and analogues. Comprehensive spectral data is collected and automatically compared to a prepared library if known drugs.
Application Notes
Tecan AC Extraction Plate™
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Tecan AC Extraction Plate™
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Tecan AC Extraction Plate™
Tecan Group Ltd.

THC , the main active compound in marijuana, is metabolized to ?9-(11-OH)-tetrahydrocannabinol (11-OH-THC) and 11-nor-?9-carboxy-tetrahydrocannabinol (THC-COOH). Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Tecan AC Extraction Plate™
Tecan Group Ltd.

Testosterone is a powerful androgen that is primarily secreted by Leydig cells in men and theca cells in women. For accurate, reproducible quantification of testosterone, a growing number of laboratories is shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS). This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform
AB SCIEX

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry
AB SCIEX

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
Can LC-MS/MS Be Used in Horse Meat Detection?
AB SCIEX

Following the Food Standards Agency’s announcement that horse and pig DNA had been identified in beef products sold by several supermarket chains, further testing has revealed widespread incidences of such contamination. This application note details a rapid, robust, sensitive and specific LC-MS/MS assay for the simultaneous detection of horse meat and the banned substance phenylbutazone (BUTE).
Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples
AB SCIEX

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.
Automated Liquid-liquid Extraction of 25-Hydroxy Vitamin D from Serum and Preparation for LC/MC Analysis Using the Hamilton Robotics Microlab STARlet Workstation
Hamilton

This application note demonstrates the automation capabilities of Hamilton Robotics’ Microlab STARlet and how it can be used to prepare clinical serum samples for Vitamin D analysis quickly, reliably and cost effectively.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation

In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
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