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 | Homology-Driven Proteomics by LC-MS/MS Dr. Andrej Shevchenko, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), speaking at Mass Spec Europe 2011. |
 | HDMSE for Quantitative and Qualitative Profiling of Complex Protein Samples Dr Joanne Connolly, Waters Corporation, speaking at Mass Spec Europe 2011. |
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Using a Spike-in Experiment to Evaluate Analysis of LC-MS Data
Data from the spike-in experiment can be used for developing and optimizing LC-MS data preprocessing algorithms and to evaluate workflows implemented in existing software tools.
LC-Tandem MS Analysis of Perfluorooctane Sulfonate and Perfluorooctanoic Acid in Fish Fillets
The methodology, developed by researchers from Mario Negri Institute, can be used to monitor and assess human exposure to perfluorinated compounds through sea food consumption.
Lipidomics of Intact Mitochondria by MALDI-TOF/MS
Researchers from University of Bari Aldo Moro describe a simple and fast method of lipid analyses of isolated intact mitochondria by means of MALDI-TOF mass spectrometry.
Characterisation of Flavonoid Aglycones by Negative Ion Chip-Based Nanospray Tandem Mass Spectrometry
Researchers from the University of Bristol employ this technique for the identification of medium-polarity flavonoids from a simple extract of green tea without employing any prior sample preparation, cleanup or chromatography.
Warwick Researchers Solve 40-year-old Fourier Transform Mass Spectrometry Phasing Problem
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry at no extra cost.
Proteomics: Top European Researcher Scoops two Prestigious Science Awards
A German researcher has just been awarded not one but two top science accolades for his research in mass spectrometry.
Breakthrough Proteomics Technique SWATH™ Acquisition is Made Available to the Worldwide Scientific Community
Data-independent SWATH™ Acquisition on the TripleTOF™ 5600 system enables comprehensive proteome-wide quantitation and is published in Molecular and Cellular Proteomics.
Proteomic Profiling and Protein Identification by MALDI-TOF Mass Spectrometry in Unsequenced Parasitic Nematodes
Researchers from the University of Liverpool utilise MALDI-TOF MS in conjunction with Peptide Mass Fingerprint searching for the reliable protein identification in unsequenced organisms.
Development of a Screening Method for the Determination of PCBs in Water
This novel method utilises gas chromatography coupled to triple quadrupole mass spectrometry for the simultaneous analysis of 11 polychlorinated biphenyls.
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
This paper provides an overview of the data processing tools available, offering a review of the collection of recent reports on the topic.
Data from the spike-in experiment can be used for developing and optimizing LC-MS data preprocessing algorithms and to evaluate workflows implemented in existing software tools.
LC-Tandem MS Analysis of Perfluorooctane Sulfonate and Perfluorooctanoic Acid in Fish Fillets
The methodology, developed by researchers from Mario Negri Institute, can be used to monitor and assess human exposure to perfluorinated compounds through sea food consumption.
Lipidomics of Intact Mitochondria by MALDI-TOF/MS
Researchers from University of Bari Aldo Moro describe a simple and fast method of lipid analyses of isolated intact mitochondria by means of MALDI-TOF mass spectrometry.
Characterisation of Flavonoid Aglycones by Negative Ion Chip-Based Nanospray Tandem Mass Spectrometry
Researchers from the University of Bristol employ this technique for the identification of medium-polarity flavonoids from a simple extract of green tea without employing any prior sample preparation, cleanup or chromatography.
Warwick Researchers Solve 40-year-old Fourier Transform Mass Spectrometry Phasing Problem
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry at no extra cost.
Proteomics: Top European Researcher Scoops two Prestigious Science Awards
A German researcher has just been awarded not one but two top science accolades for his research in mass spectrometry.
Breakthrough Proteomics Technique SWATH™ Acquisition is Made Available to the Worldwide Scientific Community
Data-independent SWATH™ Acquisition on the TripleTOF™ 5600 system enables comprehensive proteome-wide quantitation and is published in Molecular and Cellular Proteomics.
Proteomic Profiling and Protein Identification by MALDI-TOF Mass Spectrometry in Unsequenced Parasitic Nematodes
Researchers from the University of Liverpool utilise MALDI-TOF MS in conjunction with Peptide Mass Fingerprint searching for the reliable protein identification in unsequenced organisms.
Development of a Screening Method for the Determination of PCBs in Water
This novel method utilises gas chromatography coupled to triple quadrupole mass spectrometry for the simultaneous analysis of 11 polychlorinated biphenyls.
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
This paper provides an overview of the data processing tools available, offering a review of the collection of recent reports on the topic.
BIOCRATES Goes Spain and Turkey
Austrian diagnostic expert in personalized medicine continues to expand its European distribution network.
IONICON Announces New Distribution Partner for Singapore, Malaysia and Thailand
IONICON and Omega join efforts in Southeast Asia.
Bruker and SAT Announce Joint Publication
Publication of study on SISCAPA-MALDI-TOF mass spectrometry for biomarker validation and clinical research.
IBO Releases 2012 Instrument Industry Forecast
Instrument industry to grow 5.5% in 2012.
Shimadzu and The University of Texas Form Shimadzu Center for Advanced Analytical Chemistry
Located in the university’s Chemistry & Physics Building, the center contains $6 million of chromatography, mass spectrometry and spectroscopy equipment, which is the largest installation of Shimadzu analytical instrumentation in the Western Hemisphere.
Bruker and UMCG Announce a Collaboration within New ENRIA
Collaboration for MALDI-TOF mass spectrometry-based microbial identification.
Waters Selects Prof. Pauline Rudd for Center of Innovation Program Honors
Waters-NIBRT partnership advances biopharmaceutical research, characterization and training.
Agilent and Universiti Putra Malaysia to Collaborate on Halal Food Research
Agilent will provide HPRI with the Agilent 6490 triple quadrupole LC/MS system.
AB SCIEX Announces Academic Partnership Program
The program aims to increase the number of scientists who benefit from the company’s assistance and resources for advancing research in proteomics, metabolomics and lipidomics.
Pittcon 2012 Releases Conference Summary
The Pittcon 2012 Organizing Committee announced that this year's conference and exposition for laboratory science attracted 15,754 attendees (conferees and exhibitor personnel) to the annual event.
Austrian diagnostic expert in personalized medicine continues to expand its European distribution network.
IONICON Announces New Distribution Partner for Singapore, Malaysia and Thailand
IONICON and Omega join efforts in Southeast Asia.
Bruker and SAT Announce Joint Publication
Publication of study on SISCAPA-MALDI-TOF mass spectrometry for biomarker validation and clinical research.
IBO Releases 2012 Instrument Industry Forecast
Instrument industry to grow 5.5% in 2012.
Shimadzu and The University of Texas Form Shimadzu Center for Advanced Analytical Chemistry
Located in the university’s Chemistry & Physics Building, the center contains $6 million of chromatography, mass spectrometry and spectroscopy equipment, which is the largest installation of Shimadzu analytical instrumentation in the Western Hemisphere.
Bruker and UMCG Announce a Collaboration within New ENRIA
Collaboration for MALDI-TOF mass spectrometry-based microbial identification.
Waters Selects Prof. Pauline Rudd for Center of Innovation Program Honors
Waters-NIBRT partnership advances biopharmaceutical research, characterization and training.
Agilent and Universiti Putra Malaysia to Collaborate on Halal Food Research
Agilent will provide HPRI with the Agilent 6490 triple quadrupole LC/MS system.
AB SCIEX Announces Academic Partnership Program
The program aims to increase the number of scientists who benefit from the company’s assistance and resources for advancing research in proteomics, metabolomics and lipidomics.
Pittcon 2012 Releases Conference Summary
The Pittcon 2012 Organizing Committee announced that this year's conference and exposition for laboratory science attracted 15,754 attendees (conferees and exhibitor personnel) to the annual event.
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Processing and Managing Analytical Data to Extract Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
UPLC-MS/MS for the Screening, Confirmation and Quantification of 32 Drugs Illegally Added to Herbal/Dietary Supplements for the Enhancement of Male Sexual Performance
Supreme Council of Health, Qatar
This poster outlines development of a novel screening method that is suitable for both the detection of known and unknown ED drugs and analogues. Comprehensive spectral data is collected and automatically compared to a prepared library if known drugs.
Ion Chromatography ICP-Q-MS for the Detection of Arsenic Species in Apple Juice
Thermo Scientific
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
ACD Labs
To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.
Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
The LAB2LAB™Advantage
1Novartis 2TTPLabtech Ltd
Lab2Lab is a novel approach to submitting and transporting samples for analysis across an entire site. Sample tubes are registered and methods selected, an ELN reference is assigned and the sample tube is placed into the “Sender”. The system transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.
Qualitative Comparison of Wine Process Samples with UHPLC and Ultra-High Resolution TOFMS
Leco Corporation
The evaluation, identification, and quantitation of flavones, antioxidants and related nutrients, biogenic amines, and potential contaminants in wine and other foodstuffs provides valuable information on their nutritional and health values.
Analysis of Pesticide Residues in JonaGold Apples Using QuEChERS Approach and Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
LECO Corporation
Screening and quantitation of pesticide residues in fruits and vegetables is of utmost importance for public health and safety concerns. These commodities can contain hundreds-to-thousands of analytes, making them extremely difficult for the screening and accurate quantitation of pesticide residues.
Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach
LECO Corporation
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry
LECO Corporation
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
UPLC-MS/MS for the Screening, Confirmation and Quantification of 32 Drugs Illegally Added to Herbal/Dietary Supplements for the Enhancement of Male Sexual Performance
Supreme Council of Health, Qatar
This poster outlines development of a novel screening method that is suitable for both the detection of known and unknown ED drugs and analogues. Comprehensive spectral data is collected and automatically compared to a prepared library if known drugs.
Ion Chromatography ICP-Q-MS for the Detection of Arsenic Species in Apple Juice
Thermo Scientific
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
ACD Labs
To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.
Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
The LAB2LAB™Advantage
1Novartis 2TTPLabtech Ltd
Lab2Lab is a novel approach to submitting and transporting samples for analysis across an entire site. Sample tubes are registered and methods selected, an ELN reference is assigned and the sample tube is placed into the “Sender”. The system transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.
Qualitative Comparison of Wine Process Samples with UHPLC and Ultra-High Resolution TOFMS
Leco Corporation
The evaluation, identification, and quantitation of flavones, antioxidants and related nutrients, biogenic amines, and potential contaminants in wine and other foodstuffs provides valuable information on their nutritional and health values.
Analysis of Pesticide Residues in JonaGold Apples Using QuEChERS Approach and Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
LECO Corporation
Screening and quantitation of pesticide residues in fruits and vegetables is of utmost importance for public health and safety concerns. These commodities can contain hundreds-to-thousands of analytes, making them extremely difficult for the screening and accurate quantitation of pesticide residues.
Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach
LECO Corporation
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry
LECO Corporation
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection
Waters Corporation
We demonstrate the detection and identification of pesticide poisons ingested by a protected bird of prey. ACQUITY UPLC coupled with Xevo G2 QTof were used to screen samples suspected of pesticide poisoning and identify the pesticides used.
Metals in Medicine: Collision Cross-Section Comparisons Across Different Travelling-Wave Based Ion Mobility Instrument Platforms
Waters Corporation
Here, we demonstrate through example of low molecular weight anti-cancer drugs and intact protein anti-cancer drug complexes, that the travelling-wave measured collision cross-sections are consistent between the SYNAPT HDMS and G2 platforms.
RADAR - a Xevo TQ-S function - Combined with Low-High pH UPLC Screening For Fast Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
Determination of Sulfonamide Antibiotics in Wastewater by LC / MS
Thermo Fisher Scientific
Sulfonamides are a common class of synthetic antimicrobials that are widely used in human and veterinary medicine and also as additives in animal feed. They are regarded as emerging environmental contaminants.
A New Matrix Application Device for MALDI Tissue Imaging
Bruker Daltonics
ImagePrep™ provides highly reproducible matrix preparations for MALDI tissue imaging in a fully automated process.
Multi-target Compound Analysis of Pesticides
Bruker Daltonik
Compared to classical approaches by triple quadrupole instruments, an ESI-TOF MS solution allows to screen a high number of targets within one LC-run and without the loss of sensitivity; it allows identification of unknown peaks based on accurate mass and isotopic pattern information (SigmaFit) while data can be archived and reprocessed later for additional compounds as well as data can be profiled for further statistical evaluation.
The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL
Thermo Fisher Scientific
It demonstrates several key performance features of the LCQ Fleet in the analysis of natural product extracts from cinnamon. Identification of multiple polyphenols in a single chromatographic analysis was achieved using the fast cycle time, high MSn sensitivity, PQD and High Resolution Isolation of the LCQ Fleet. In addition, simple data interpretation with Mass Frontier provides confident structural identification.
A Quantitative Screen for Multiple Classes of Illicit Drugs and Their Primary Metabolites in Human Biological Fluids by LC-MS/MS
Thermo Fisher Scientific
Currently, GC/MS is the method of choice for quantifying drugs of abuse. In recent years, however, many forensic and toxicology labs have been switching to LC-MS/MS methods, which do not require time-consuming derivatization or extensive sample cleanup necessary in GC/MS analyses. Yet, many of the LC-MS/MS methods described in the literature either assay a limited number of illicit drug classes or do not include their primary metabolites of these illicit drugs.
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection
Waters Corporation
We demonstrate the detection and identification of pesticide poisons ingested by a protected bird of prey. ACQUITY UPLC coupled with Xevo G2 QTof were used to screen samples suspected of pesticide poisoning and identify the pesticides used.
Metals in Medicine: Collision Cross-Section Comparisons Across Different Travelling-Wave Based Ion Mobility Instrument Platforms
Waters Corporation
Here, we demonstrate through example of low molecular weight anti-cancer drugs and intact protein anti-cancer drug complexes, that the travelling-wave measured collision cross-sections are consistent between the SYNAPT HDMS and G2 platforms.
RADAR - a Xevo TQ-S function - Combined with Low-High pH UPLC Screening For Fast Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
Determination of Sulfonamide Antibiotics in Wastewater by LC / MS
Thermo Fisher Scientific
Sulfonamides are a common class of synthetic antimicrobials that are widely used in human and veterinary medicine and also as additives in animal feed. They are regarded as emerging environmental contaminants.
A New Matrix Application Device for MALDI Tissue Imaging
Bruker Daltonics
ImagePrep™ provides highly reproducible matrix preparations for MALDI tissue imaging in a fully automated process.
Multi-target Compound Analysis of Pesticides
Bruker Daltonik
Compared to classical approaches by triple quadrupole instruments, an ESI-TOF MS solution allows to screen a high number of targets within one LC-run and without the loss of sensitivity; it allows identification of unknown peaks based on accurate mass and isotopic pattern information (SigmaFit) while data can be archived and reprocessed later for additional compounds as well as data can be profiled for further statistical evaluation.
The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL
Thermo Fisher Scientific
It demonstrates several key performance features of the LCQ Fleet in the analysis of natural product extracts from cinnamon. Identification of multiple polyphenols in a single chromatographic analysis was achieved using the fast cycle time, high MSn sensitivity, PQD and High Resolution Isolation of the LCQ Fleet. In addition, simple data interpretation with Mass Frontier provides confident structural identification.
A Quantitative Screen for Multiple Classes of Illicit Drugs and Their Primary Metabolites in Human Biological Fluids by LC-MS/MS
Thermo Fisher Scientific
Currently, GC/MS is the method of choice for quantifying drugs of abuse. In recent years, however, many forensic and toxicology labs have been switching to LC-MS/MS methods, which do not require time-consuming derivatization or extensive sample cleanup necessary in GC/MS analyses. Yet, many of the LC-MS/MS methods described in the literature either assay a limited number of illicit drug classes or do not include their primary metabolites of these illicit drugs.
