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 | Micro Separation LC-MS Methods for Improving Retrospective Detection of Drug Administration for Evidential Purposes Mark Parkin, King's College London, speaking at Advances in Separation Technology 2011. |
 | Quantitative Proteomics For Biomarker Discovery and Validation: Prostate Cancer Case Study Stephen Pennington, UCD Dublin, Professor of Proteomics, speaking at European Biomarkers Summit 2011. |
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Two Decades of Studying Non-Covalent Biomolecular Assemblies by Means of Electrospray Ionization Mass Spectrometry
MS has evolved to impact a wide range of applications in structural biology. This paper charts some of the milestones in MS development as they pertain to the study of non-covalent complexes, and the novel applications they have enabled.
Quantitative Trace Analysis of a Broad Range of Antiviral Drugs in Poultry Muscle
Researchers from RIKILT-Institute of Food Safety report an LC-tandem mass spectrometry for the analysis of seven antiviral drugs in poultry muscle.
Discovery of Early-Stage Biomarkers for Diabetic Kidney Disease using MS-Based Metabolomics
This study demonstrates the potential of multivariate data analysis and metabolomics in the field of diabetic complications.
Proteomics Analyses of the Opportunistic Pathogen Burkholderia vietnamiensis using Protein Fractionations and Mass Spectrometry
Researchers from the University of Arizona have identified more than 1200 proteins, approximately 16% of the proteins coded from the annotated genome of Burkholderia species.
Sequential Multiplexed Analyte Quantification using Peptide Immunoaffinity Enrichment Coupled to Mass Spectrometry
Researchers from Fred Hutchinson Cancer Research Center have demonstrated the utility of immunoaffinity selected reaction monitoring mass spectrometry for analyzing large numbers of analytes.
Estimation of Absolute Protein Quantities of Unlabeled Samples by Selected Reaction Monitoring Mass Spectrometry
Researchers from ETH Zurich demonstrate the utility of a targeting mass spectrometric technique for the estimation of absolute protein abundance in unlabeled and non-fractionated cell lysates.
Analysis of Bromate in Drinking Water using Liquid Chromatography-Tandem Mass Spectrometry without Sample Pretreatment
Researchers from the National Institute of Public Health have developed an analytical method for determining bromate in drinking water using liquid chromatography-tandem mass spectrometry.
A Comprehensive GC-MS Sub-Microscale Assay for Fatty Acids and its Applications
Researchers have developed a highly sensitive technique that allows for population analyses across a wide variety of organisms.
Evaluating Changes in Biodesix’s VeriStrat Test over the Course of Treatment with Gefitinib
“Changes in plasma mass-spectral (VeriStrat) profile in course of treatment of NSCLC patients with EGFR-TKIs,” is published in the November issue of the Journal of Thoracic Oncology.
Structural Characterization of Wax Esters by Electron Ionization Mass Spectrometry
This study discusses the interpretation of the electron ionization mass spectra of straight-chain and methyl-branched saturated and unsaturated wax esters based on the spectra of 154 standards.
MS has evolved to impact a wide range of applications in structural biology. This paper charts some of the milestones in MS development as they pertain to the study of non-covalent complexes, and the novel applications they have enabled.
Quantitative Trace Analysis of a Broad Range of Antiviral Drugs in Poultry Muscle
Researchers from RIKILT-Institute of Food Safety report an LC-tandem mass spectrometry for the analysis of seven antiviral drugs in poultry muscle.
Discovery of Early-Stage Biomarkers for Diabetic Kidney Disease using MS-Based Metabolomics
This study demonstrates the potential of multivariate data analysis and metabolomics in the field of diabetic complications.
Proteomics Analyses of the Opportunistic Pathogen Burkholderia vietnamiensis using Protein Fractionations and Mass Spectrometry
Researchers from the University of Arizona have identified more than 1200 proteins, approximately 16% of the proteins coded from the annotated genome of Burkholderia species.
Sequential Multiplexed Analyte Quantification using Peptide Immunoaffinity Enrichment Coupled to Mass Spectrometry
Researchers from Fred Hutchinson Cancer Research Center have demonstrated the utility of immunoaffinity selected reaction monitoring mass spectrometry for analyzing large numbers of analytes.
Estimation of Absolute Protein Quantities of Unlabeled Samples by Selected Reaction Monitoring Mass Spectrometry
Researchers from ETH Zurich demonstrate the utility of a targeting mass spectrometric technique for the estimation of absolute protein abundance in unlabeled and non-fractionated cell lysates.
Analysis of Bromate in Drinking Water using Liquid Chromatography-Tandem Mass Spectrometry without Sample Pretreatment
Researchers from the National Institute of Public Health have developed an analytical method for determining bromate in drinking water using liquid chromatography-tandem mass spectrometry.
A Comprehensive GC-MS Sub-Microscale Assay for Fatty Acids and its Applications
Researchers have developed a highly sensitive technique that allows for population analyses across a wide variety of organisms.
Evaluating Changes in Biodesix’s VeriStrat Test over the Course of Treatment with Gefitinib
“Changes in plasma mass-spectral (VeriStrat) profile in course of treatment of NSCLC patients with EGFR-TKIs,” is published in the November issue of the Journal of Thoracic Oncology.
Structural Characterization of Wax Esters by Electron Ionization Mass Spectrometry
This study discusses the interpretation of the electron ionization mass spectra of straight-chain and methyl-branched saturated and unsaturated wax esters based on the spectra of 154 standards.
Applied Kilovolts Makes Board Level Engineering Appointment
Appointment of Ian Lake as design engineering director.
AB SCIEX and Phenomenex Mobile Laboratory to address Food Safety, Clinical Research, Forensics and the Environment
The North American tour will commence at Pittcon 2012 to demonstrate next-generation LC/MS/MS workflows.
Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.
Advion Appoints Chinese Distributor of its Compact Mass Spectrometer
Universal Analytical and Testing Instruments, Ltd. has been appointed as the exclusive distributor for the expression compact mass spectrometer.
Separation and Detection Streams Combined
Select Biosciences, organisers of European Lab Automation (ELA) 2012, has incorporated Separation and Detection as one of the eight available conference streams.
Waters and Tecan Sign Agreement for Clinical Assay Platform
The agreement will address the growing need for greater efficiencies and throughput that can be obtained with the automation of routine clinical laboratory assays.
Agilent Technologies Lists LC and Mass Spec Systems as Class I Devices with FDA
The Infinity Series 1200 liquid chromatography systems and 6000 Series mass spectrometry systems have been listed as Class I medical devices with the U.S. Food and Drug Administration.
AB SCIEX and Indigo to Market Mass Spectrometry Solutions
AB SCIEX and Indigo BioSystems have entered into a collaboration to jointly market mass spectrometry solutions that simplifies LC/MS/MS workflows.
Agilent and Integrated Diagnostics Enter Strategic Partnership
The partnership will develop protein-based assays for early disease detection.
Thermo Fisher Scientific and PREMIER Biosoft to Co-market SimGlycan Software
Goal is to advance glycobiology by dramatically speeding glycan characterization.
Appointment of Ian Lake as design engineering director.
AB SCIEX and Phenomenex Mobile Laboratory to address Food Safety, Clinical Research, Forensics and the Environment
The North American tour will commence at Pittcon 2012 to demonstrate next-generation LC/MS/MS workflows.
Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.
Advion Appoints Chinese Distributor of its Compact Mass Spectrometer
Universal Analytical and Testing Instruments, Ltd. has been appointed as the exclusive distributor for the expression compact mass spectrometer.
Separation and Detection Streams Combined
Select Biosciences, organisers of European Lab Automation (ELA) 2012, has incorporated Separation and Detection as one of the eight available conference streams.
Waters and Tecan Sign Agreement for Clinical Assay Platform
The agreement will address the growing need for greater efficiencies and throughput that can be obtained with the automation of routine clinical laboratory assays.
Agilent Technologies Lists LC and Mass Spec Systems as Class I Devices with FDA
The Infinity Series 1200 liquid chromatography systems and 6000 Series mass spectrometry systems have been listed as Class I medical devices with the U.S. Food and Drug Administration.
AB SCIEX and Indigo to Market Mass Spectrometry Solutions
AB SCIEX and Indigo BioSystems have entered into a collaboration to jointly market mass spectrometry solutions that simplifies LC/MS/MS workflows.
Agilent and Integrated Diagnostics Enter Strategic Partnership
The partnership will develop protein-based assays for early disease detection.
Thermo Fisher Scientific and PREMIER Biosoft to Co-market SimGlycan Software
Goal is to advance glycobiology by dramatically speeding glycan characterization.
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Ion Chromatography ICP-Q-MS for the Detection of Arsenic Species in Apple Juice
Thermo Scientific
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
ACD Labs
To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.
Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
The LAB2LAB™Advantage
1Novartis 2TTPLabtech Ltd
Lab2Lab is a novel approach to submitting and transporting samples for analysis across an entire site. Sample tubes are registered and methods selected, an ELN reference is assigned and the sample tube is placed into the “Sender”. The system transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.
Qualitative Comparison of Wine Process Samples with UHPLC and Ultra-High Resolution TOFMS
Leco Corporation
The evaluation, identification, and quantitation of flavones, antioxidants and related nutrients, biogenic amines, and potential contaminants in wine and other foodstuffs provides valuable information on their nutritional and health values.
Analysis of Pesticide Residues in JonaGold Apples Using QuEChERS Approach and Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
LECO Corporation
Screening and quantitation of pesticide residues in fruits and vegetables is of utmost importance for public health and safety concerns. These commodities can contain hundreds-to-thousands of analytes, making them extremely difficult for the screening and accurate quantitation of pesticide residues.
Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach
LECO Corporation
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry
LECO Corporation
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
Detection and Identification of Dispersants (COREXIT® 9527 and 9500) by GC/MS and LC-MS/MS
Phenomenex
Dispersants are plasticizers commonly used to prevent clumping and help dissipate oil slicks. In this work, we used GC/MS and LC-MS/ MS to detect and indentify two of the most widely used dispersants (Corexit 9527 and 9500).
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
Thermo Scientific
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
ACD Labs
To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.
Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
The LAB2LAB™Advantage
1Novartis 2TTPLabtech Ltd
Lab2Lab is a novel approach to submitting and transporting samples for analysis across an entire site. Sample tubes are registered and methods selected, an ELN reference is assigned and the sample tube is placed into the “Sender”. The system transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.
Qualitative Comparison of Wine Process Samples with UHPLC and Ultra-High Resolution TOFMS
Leco Corporation
The evaluation, identification, and quantitation of flavones, antioxidants and related nutrients, biogenic amines, and potential contaminants in wine and other foodstuffs provides valuable information on their nutritional and health values.
Analysis of Pesticide Residues in JonaGold Apples Using QuEChERS Approach and Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
LECO Corporation
Screening and quantitation of pesticide residues in fruits and vegetables is of utmost importance for public health and safety concerns. These commodities can contain hundreds-to-thousands of analytes, making them extremely difficult for the screening and accurate quantitation of pesticide residues.
Analysis of Fruit Commodities by GC-TOFMS and GCxGC-TOFMS Using QuEChERS Approach
LECO Corporation
The availability of fruit commodities from a wide variety of sources has increased the need for rapid and accurate screening for pesticides in fruit. Not all fruit commodities are brought to market under the strict guidelines of the United States Department of Agriculture. Determining whether or not the Environmental Protection Agency tolerances for various pesticides have been violated is important in the risk assessment for consumers in the United States.
Characterization of Nutrients and Actives in Herbal Supplements and Nutriceuticals Using UHPLC-Multi-Reflecting Time-of-Flight Mass Spectrometry
LECO Corporation
The qualitative and quantitative analysis of the content of nutritional supplements and alternative medicinal therapies is becoming more important and regulation by the FDA is imminent. High resolution mass spectrometry provides a rapid, selective, and useful mechanism for QC of extracts and finished dosage forms, producing a minable, comprehensive data set.
Detection and Identification of Dispersants (COREXIT® 9527 and 9500) by GC/MS and LC-MS/MS
Phenomenex
Dispersants are plasticizers commonly used to prevent clumping and help dissipate oil slicks. In this work, we used GC/MS and LC-MS/ MS to detect and indentify two of the most widely used dispersants (Corexit 9527 and 9500).
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
Data Acquisition and Analysis of 7-ethoxycoumarin and its Metabolites Using TurboDDS Software in the 500-MS Ion Trap
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection
Waters Corporation
We demonstrate the detection and identification of pesticide poisons ingested by a protected bird of prey. ACQUITY UPLC coupled with Xevo G2 QTof were used to screen samples suspected of pesticide poisoning and identify the pesticides used.
Metals in Medicine: Collision Cross-Section Comparisons Across Different Travelling-Wave Based Ion Mobility Instrument Platforms
Waters Corporation
Here, we demonstrate through example of low molecular weight anti-cancer drugs and intact protein anti-cancer drug complexes, that the travelling-wave measured collision cross-sections are consistent between the SYNAPT HDMS and G2 platforms.
RADAR - a Xevo TQ-S function - Combined with Low-High pH UPLC Screening For Fast Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
Determination of Sulfonamide Antibiotics in Wastewater by LC / MS
Thermo Fisher Scientific
Sulfonamides are a common class of synthetic antimicrobials that are widely used in human and veterinary medicine and also as additives in animal feed. They are regarded as emerging environmental contaminants.
A New Matrix Application Device for MALDI Tissue Imaging
Bruker Daltonics
ImagePrep™ provides highly reproducible matrix preparations for MALDI tissue imaging in a fully automated process.
Multi-target Compound Analysis of Pesticides
Bruker Daltonik
Compared to classical approaches by triple quadrupole instruments, an ESI-TOF MS solution allows to screen a high number of targets within one LC-run and without the loss of sensitivity; it allows identification of unknown peaks based on accurate mass and isotopic pattern information (SigmaFit) while data can be archived and reprocessed later for additional compounds as well as data can be profiled for further statistical evaluation.
The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL
Thermo Fisher Scientific
It demonstrates several key performance features of the LCQ Fleet in the analysis of natural product extracts from cinnamon. Identification of multiple polyphenols in a single chromatographic analysis was achieved using the fast cycle time, high MSn sensitivity, PQD and High Resolution Isolation of the LCQ Fleet. In addition, simple data interpretation with Mass Frontier provides confident structural identification.
A Quantitative Screen for Multiple Classes of Illicit Drugs and Their Primary Metabolites in Human Biological Fluids by LC-MS/MS
Thermo Fisher Scientific
Currently, GC/MS is the method of choice for quantifying drugs of abuse. In recent years, however, many forensic and toxicology labs have been switching to LC-MS/MS methods, which do not require time-consuming derivatization or extensive sample cleanup necessary in GC/MS analyses. Yet, many of the LC-MS/MS methods described in the literature either assay a limited number of illicit drug classes or do not include their primary metabolites of these illicit drugs.
Agilent Technologies
The ion trap is a powerful tool for metabolism studies, due to the MSn capability for the identification of metabolites and structure elucidation of unknown peaks. The TurboDDS™ software on the Varian 500-MS LC Ion Trap eliminates the need to do multiple runs in order to identify metabolites. Once the expected m/z of a metabolite is entered into the method, the 500-MS will automatically look for this m/z and when found, will immediately trigger an MSn experiment.
A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection
Waters Corporation
We demonstrate the detection and identification of pesticide poisons ingested by a protected bird of prey. ACQUITY UPLC coupled with Xevo G2 QTof were used to screen samples suspected of pesticide poisoning and identify the pesticides used.
Metals in Medicine: Collision Cross-Section Comparisons Across Different Travelling-Wave Based Ion Mobility Instrument Platforms
Waters Corporation
Here, we demonstrate through example of low molecular weight anti-cancer drugs and intact protein anti-cancer drug complexes, that the travelling-wave measured collision cross-sections are consistent between the SYNAPT HDMS and G2 platforms.
RADAR - a Xevo TQ-S function - Combined with Low-High pH UPLC Screening For Fast Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
Determination of Sulfonamide Antibiotics in Wastewater by LC / MS
Thermo Fisher Scientific
Sulfonamides are a common class of synthetic antimicrobials that are widely used in human and veterinary medicine and also as additives in animal feed. They are regarded as emerging environmental contaminants.
A New Matrix Application Device for MALDI Tissue Imaging
Bruker Daltonics
ImagePrep™ provides highly reproducible matrix preparations for MALDI tissue imaging in a fully automated process.
Multi-target Compound Analysis of Pesticides
Bruker Daltonik
Compared to classical approaches by triple quadrupole instruments, an ESI-TOF MS solution allows to screen a high number of targets within one LC-run and without the loss of sensitivity; it allows identification of unknown peaks based on accurate mass and isotopic pattern information (SigmaFit) while data can be archived and reprocessed later for additional compounds as well as data can be profiled for further statistical evaluation.
The Use of FAIMS to Separate Loperamide from PEG Prior to MS Analysis Using an LTQ XL
Thermo Fisher Scientific
It demonstrates several key performance features of the LCQ Fleet in the analysis of natural product extracts from cinnamon. Identification of multiple polyphenols in a single chromatographic analysis was achieved using the fast cycle time, high MSn sensitivity, PQD and High Resolution Isolation of the LCQ Fleet. In addition, simple data interpretation with Mass Frontier provides confident structural identification.
A Quantitative Screen for Multiple Classes of Illicit Drugs and Their Primary Metabolites in Human Biological Fluids by LC-MS/MS
Thermo Fisher Scientific
Currently, GC/MS is the method of choice for quantifying drugs of abuse. In recent years, however, many forensic and toxicology labs have been switching to LC-MS/MS methods, which do not require time-consuming derivatization or extensive sample cleanup necessary in GC/MS analyses. Yet, many of the LC-MS/MS methods described in the literature either assay a limited number of illicit drug classes or do not include their primary metabolites of these illicit drugs.
