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Tuesday, November 25, 2014
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World of Technology & Science 2014...
Manual Removal of Push Caps...Interview with Dan Shine on the New Vanq...Vanquish UHPLC System...

Featured Products
Featured Product - CESI 8000 High Performance Separation-Electrospray Ionization System for Mass Spectrometry
CESI 8000 High Performance Separation-Electrospray Ionization System for Mass Spectrometry
Featured Product - DBL Series Vacuum Pump Enclosure
DBL Series Vacuum Pump Enclosure

Webcasts
Webcast - Characterizing the Early Drug Development Outsourcing Landscape Characterizing the Early Drug Development Outsourcing Landscape
Stella Stergiopoulos, Tufts Center for the Study of Drug Design, speaking at Drug Discovery and Development 2014
Webcast - Webinar: Bestimmung von Dioxinen und dioxinähnlichen PCBs mittels GC/QQQWebinar: Bestimmung von Dioxinen und dioxinähnlichen PCBs mittels GC/QQQ
Screen and Confirm Food Residues Confidently. Webinar Event for 'Food' Solutions.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Food Diagnostics Systems Market, Consumables Market & By Geography - Global Trends & Forecast To 2018
MarketsandMarkets

The food diagnostics market size is projected to increase with rising concerns over food quality and safety, and the implementation of stringent regulations on food safety and foodborne illness prevention.
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Mass Spectrometry Market by Technology & Application - Global Trends & Forecast to 2018
MarketsandMarkets

The global mass spectrometry market witnesses high competitive intensity as there are many big and small firms with similar product offerings. These companies adopt various strategies to increase their market shares and to establish a strong foothold in the global market.
Mass Spectrometry for Clinical Diagnostics Applications 2013 Focus Report
SELECTBIO

This report from SELECTBIO addresses a number of topics including, market segmentation, market landscape, and mass spectrometry products currently on the market as well as in development.
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Scientific News
Proteomics for Systems Toxicology
MS-based proteomics is maturing into a robust technology for the measurement of proteome-wide exposure effects.
Charge-Tagged Proline-Based Organocatalyst for Mechanistic Studies Using ESI-MS
In a comparative continous flow ESI-MS study, researchers use a new charged catalyst and neutral L-proline to investigate the proline-catalyzed inverse crossed aldol reaction of aldehydes with diethyl ketomalonate.
Could Non-gluten Proteins Play a Role in Celiac Disease?
Scientists are reporting in ACS’ Journal of Proteome Research that people with the disease also have reactions to non-gluten wheat proteins.
Mass Spec Sample Prep Cut From Days to Minutes
The method, developed by Livermore scientists, accommodates liquid samples and bypasses the graphitization process, enabling sample preparation and analysis in minutes.
LLNL, UC Davis Partner to Personalize Cancer Medications
With a $7.8 million, five-year grant from the NIH researchers are utilizing accelerator mass spectrometry for cancer research.
Novel Solutions to Fight the Obesity Gene
Potent inhibitors a potential new class of anti-obesity drugs that target one of the most common genetic causes of obesity.
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
Detecting Pharmaceutical and Personal Care Products in Water
A simple, more convenient method than conventional guidelines.
Mass Spectrometry in Your Hand
Electrospray arrays can dramatically downsize systems and costs for onsite chemical analysis and many other applications.
Study Aims to Develop Breath Test for COPD
A new clinical iniative, lead by NYU Langone Medical Center, aims to determine a breath test’s effectiveness to identify volatile organic compounds (VOCs) in human breath that are biomarkers of chronic obstructive pulmonary disease (COPD).
Business News
Beckman, U of Birmingham Form Technology Collaboration
The partnership is aimed at advancing automation techniques for regulatory science research.
Bruker Sells GC Business
Bruker completed the divestiture of its GC and GC single-quadrupole (GC-SQ) mass spectrometry products to Techcomp Europe Ltd on October 31st.
Molecular Profiles, Xceleron Drug Development Partnership
Companies announce a collaboration to assist drug developers with improved efficiency during clinical development.
AB SCIEX Wins New Product Innovation Award in Asia Pacific
The award recognizes the company’s continued innovation in the mass spectrometry industry and a number of new products introduced into the market in recent years.
Waters Centers of Innovation Program Honors CSU Laboratory
Proteomics and metabolomics facility recognized for innovation in biological mass spectrometry.
Massimo Pietropaolo Named McNair Scholar at Baylor
World renowned physician-scientist in type 1 diabetes research, Dr. Massimo Pietropaolo, has been named McNair Scholar at Baylor College of Medicine.
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Waters Q3 Revenues up 8 Percent
Company reports third quarter sales of $493 million, an increase of 8% versus sales of $457 million in the third quarter of 2013.
AB SCIEX Scientist Wins HUPO 2014 Science and Technology Award
Winner becomes second team member to be recognized for the commercialization of transformative chemistries such as iTRAQ® eagents.
Sinensis Life Sciences Acquires Spinnovation
Addition of Spinnovation expands and strengthens Company’s chemical R&D group.

Events
CMC Strategy Forum Japan 2014
08 Dec 2014
CMC Strategy Forum Japan 2014 ...
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CMC Strategy Forum Winter 2015
26 Jan 2015
CMC Strategy Forum Winter 2015 ...
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SLAS2015
07 Feb 2015
SLAS2015 ...
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Featured Event - European Winter Conference on
22 Feb 2015
European Winter Conference on ...
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ePosters
METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF METHYLMERCURY AND INORGANIC MERCURY IN SEAFOOD
University of Barcelona, Universidade Federal do Rio Grande do Sul

This work reports the method development for the simultaneous determination of methylmercury (MeHg+) and inorganic mercury (iHg) species in seafood. The study focused on the extraction and quantification of MeHg+ by liquid chromatography coupled to on-line UV irradiation and cold vapour atomic fluorescence spectroscopy (LC-UV-HG-AFS), using HCl 4 mol L-1 as extractant agent.
Microextraction techniques combined with X-ray fluorescence spectrometry for determination of different metal ions in water
(a) Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland (b) Department of Chemistry, University of Girona, Campus Montilivi s/n, 17170-Girona, Spain (c) Institute of Eart

In present work new preconcentration procedures combining microextraction techniques and X-ray fluorescence spectroscopy were developed. Proposed methodologies are promising tools for multielemental analysis enabling detection of natural pollutants in different water samples.

Application of Central Composite Design (CCD) for the Optimization of Ultrasound-assisted Extraction (UAE) of Phenolics from Corn (Zea mays)
1Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora, 55281, Yogyakarta, Indonesia. 2Department of Ana

A new Ultrasound-assisted Extraction (UAE) of phenolic compounds from corn (Zea mays) has been optimized by means of chemometrics tool. The proposed method was validated and successfully applied to the analysis of phenolics content in several corn cultivars.
MsCompare: An Untargeted LC & GC/MS Metabolomics Platform for Quality Control, Precise Deconvolution and Data Analysis
MsMetrix, the Netherlands

A GC/MS or LC/MS workflow for Metabolomics applications includes a number of distinct steps: experimental design, sampling, sample preparation, data acquisition, data processing, deconvolution, identification and data interpretation.

The MsXelerator software includes Quality Control procedures and Analysis of Variance (ANOVA) to properly control each step in this workflow and to obtain reliable results for both quantitation and identification.
Searching for Urinary Biomarkers of Exposure to Heterocyclic Amines (HCAs)
Kingston University, National Food Institute, Technical University of Denmark, Lund University

Heterocyclic amines (HCAs) are foodborne carcinogens present in cooked meat and fish, mainly. Metabolites of HCAs have been determined in urine from volunteers following a controlled meal.
Mixtures Analysis of Complex Mixtures
Mestrelab Research

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
A Complete Wine Analysis Using Multiplets Detection
1Mestrelab Research, www.mestrelab.com; 2Institut Heidger, Germany, www.institut-heidger.de

NMR mixtures analysis can be used to determine the concentration of key components in wine. Here we show the analysis using SMA from Mestrelab.
DPPH scavenging activities of selected flavonoids and their mixtures
(1) Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University in Bratislava, Slovakia

The aim is to identify the ati-oxidant activity of selected flavonoids (quercetin, luteolin and galangin) and their mixtures using DPPH method including their synergistic or antagonistic interactions.
Correlation between plasma levels of lutein and oxidized low density lipoproteins: a short human intervention study
Università Politecnica delle Marche

The increase of plasma carotenoids, in particular lutein, after dietary treatment for two weeks is associated with a significant protective effect against lipid peroxidation of plasma lipoproteins.
Analysis of 10 systemic pesticide residues in various baby foods using liquid chromatography-tandem mass spectrometry
Natural Products Chemistry Laboratory, Biotechnology Research Institute, College of Agriculture and Life Science, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Kore

The method developed was sensitive and selective, and detected the analytes below the MRL established by the European Commission and the Korea Food and Drug Administration. The combination of QuEChERS sample preparation and LC-MS/MS analysis provided acceptable quantitative and qualitative results in baby food.
Application Notes
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform
AB SCIEX

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry
AB SCIEX

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
Can LC-MS/MS Be Used in Horse Meat Detection?
AB SCIEX

Following the Food Standards Agency’s announcement that horse and pig DNA had been identified in beef products sold by several supermarket chains, further testing has revealed widespread incidences of such contamination. This application note details a rapid, robust, sensitive and specific LC-MS/MS assay for the simultaneous detection of horse meat and the banned substance phenylbutazone (BUTE).
Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples
AB SCIEX

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.
Automated Liquid-liquid Extraction of 25-Hydroxy Vitamin D from Serum and Preparation for LC/MC Analysis Using the Hamilton Robotics Microlab STARlet Workstation
Hamilton

This application note demonstrates the automation capabilities of Hamilton Robotics’ Microlab STARlet and how it can be used to prepare clinical serum samples for Vitamin D analysis quickly, reliably and cost effectively.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation

In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
SELECTBIO
SELECTBIO Market Reports
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