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Webcasts
Webcast - LC-High Resolution-MS in Clinical Labs: A Step Forward for TDM and MetabotypingLC-High Resolution-MS in Clinical Labs: A Step Forward for TDM and Metabotyping
Bertrand Rochat, Centre Hospitalier Universitaire Vaudois, speaking at Clinical Applications of Mass Spectrometry.
Webcast - Creating a Clinical Diagnostic Test from Discovery Through Launch with Mass SpectrometryCreating a Clinical Diagnostic Test from Discovery Through Launch with Mass Spectrometry
Daniel Chelsky, Caprion Proteomics Inc, speaking at Diagnostics & Biomarkers.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Food Diagnostics Systems Market, Consumables Market & By Geography - Global Trends & Forecast To 2018
MarketsandMarkets

The food diagnostics market size is projected to increase with rising concerns over food quality and safety, and the implementation of stringent regulations on food safety and foodborne illness prevention.
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Mass Spectrometry Market by Technology & Application - Global Trends & Forecast to 2018
MarketsandMarkets

The global mass spectrometry market witnesses high competitive intensity as there are many big and small firms with similar product offerings. These companies adopt various strategies to increase their market shares and to establish a strong foothold in the global market.
Mass Spectrometry for Clinical Diagnostics Applications 2013 Focus Report
SELECTBIO

This report from SELECTBIO addresses a number of topics including, market segmentation, market landscape, and mass spectrometry products currently on the market as well as in development.
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Scientific News
Fake Malaria Drugs Not As Common As Previously Reported
Researchers welcome reassuring findings but note poor quality drugs are still a problem.
New Technology For Early Detection Of Stomach Cancer
The innovative method identifies persons at risk for developing stomach cancer and for detecting tumors at an earlier stage.
New Tool To Explore Mysteries Of The Immune System
Yale scientists use CyTOF to study a range of conditions.
IUPUI Chemist Earns Grant to Improve Drug Screening in Forensics
$273,826 award to improve the speed and accuracy of mass spectrometry for detecting drugs and poisons.
Protein The Clue To Solving A Darwinian Mystery
Scientists at the University of York provided the key to solving the evolutionary puzzle surrounding that Charles Darwin called the ‘strangest animals ever discovered’.
High-End Imaging Techniques Blended
Vanderbilt University researchers have achieved the first “image fusion” of mass spectrometry and microscopy — a technical tour de force that could, among other things, dramatically improve the diagnosis and treatment of cancer.
DNA Safeguard May Be Key In Cancer Treatment
Cornell researchers have developed a new technique to understand the actions of key proteins required for cancer cells to proliferate.
Boy or Girl? Lemur Scents Have the Answer
A new study finds that a pregnant lemur’s signature scent depends in part on whether she’s carrying a girl or a boy.
Identification of Fumonisins in Corn
In this study, fumonisin A1, A2, and a3 are identified and quantified by high-resolution liquid chromatography-orbitrap mass spectrometry.
Ground-Breaking Lung Cancer Breath Test In Clinical Trial
University of Leicester and Leicester’s Hospitals to evaluate revolutionary device which detects lung cancer in early stages.
Business News
Agilent Collaborate with National University of Singapore
Company to support NUS Medicine's research for safer, more effective medicine for heart disease.
Markes International Wins Queen’s Award for Enterprise
Markes International has had its export success recognised through receiving a Queen’s Award for Enterprise.
New Grant Funds Bacterial Library to Aid Diagnosis
Researchers at the University of Maryland will use grant to create a bacterial library using mass spectrometry.
Analytical Innovations Bring $10 Million Back to National Laboratory, Battelle
Advances enhance performance of mass spectrometers.
Protea to Acquire vivoPharm
Combined company to develop and market new services for pharmaceutical R&D.
Shimadzu Nexera UC Recognized at Pittcon 2015 with Editors’ Gold Award
Company has received the award at the 2015 Pittsburg Conference on Analytical Chemistry and Applied Spectroscopy (Pittcon).
SCIEX and Mass Consortium Corporation Announce Exclusive Reseller Agreement
SCIEX to provide customers with XCMSplus software solution for simplified and accelerated metabolomics workflows.
Denator and Maastricht MultiModal Molecular Imaging Institute Collaborate
Denator enters into collaboration with newly established state-of-the-art European institute for clinical applications.
National Institute For Occupational Safety And Health Partners With Protea
NIOSH utilizes mass spectrometry imaging tools for workplace toxin inhalation studies.
Agilent Announces New CEO Mike McMullen
McMullen elected as chief executive officer by Company’s board of directors.

Events
BIT
25 Apr 2015
BIT's 4th Annual Conference an ...
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BIT
25 Apr 2015
BIT's 4th Annual Conference an ...
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CMC Strategy Forum Europe 2015
04 May 2015
CMC Strategy Forum Europe 2015 ...
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CMC Strategy Forum: The Biopha
20 Jul 2015
CMC Strategy Forum: The Biopha ...
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ePosters
TGA/IST16/GC/MS coupling : an advanced technique for LLDPE structure interpretation
1 SRA Instruments, 210 rue des Sources 69280 Marcy l'Etoile, France - 2 Université de Lyon, Univ. Lyon 1, CPE Lyon, CNRS UMR 5265, Laboratoire de Chimie Catalyse Polymères et Procédés (C2P2), Equipe

An innovative TGA/IST16/GC/MS coupling is presented.
DETERMINATION OF THE QUALITY OF ACTIVE INGREDIENTS IN PAIN KILLERS USING GC-MS
Jomo Kentyatta University of Agriculture and Technology (Kenya), and Foundation of Analytical Science and Technology in Africa (UK).

From this study, the pain killers sampled were found to have large error bars suggesting that there exist counterfeit drugs in the market. The brands mostly affected for analysis of acetaminophen were panadol, action, P500, P5500, elymol and neladol. The error bars for caffeine analysis were quite low indicating that all tablets either counterfeit or original maintained the same amount of this active ingredient.
DETERMINATION OF ESSENTIAL AND HEAVY METALS IN KENYAN HONEY BY ATOMIC ABSORPTION AND EMMISSION SPECTROSCOPY
Jomo Kenyatta University of Agriculture and Technology

Generally, honey samples recorded very low concentrations of As compared to the other heavy metals determined in this study. The highest concentration of As was recorded in honey sample from Nairobi with a value of 0.03±0.01 ppm. All the values recorded were within the KEBS permitted value of 0.5 ppm in food according to Kenya Bureaue of Standards, 1996.
Prospecting For Iron and Titanium Using Termitaria
Jomo Kenyatta University of Agriculture and Technology

This study demonstrated elevated levels of the two metals (that is iron and titanium) in termitaria soil compared to the surrounding soils. Termitaria are very important bioturbators and can therefore be used as preliminary step in mineral prospecting since they provide an indication of the potential of the positive anomaly, and enables a judgment on the scale of the metal accumulation
Integrating Fluorescent Carbon Nanodot Synthesis and Optical Detection of Methylmercury
University of Vigo (Spain)

In the last years, a great interest toward development of optical nanoprobes has arisen, so fluorescent nanomaterials have been implemented in analytical systems for the detection of several species. In this work, a novel assay that integrates the synthesis of fluorescent carbon dots (CDs) and sensing within one step, for the fast, sensitive and selective detection of methylmercury is presented.
A FastGC Proton-Transfer-Reaction Quadrupole Ion Guide Time-of-Flight (PTR-QiTOF) Mass Spectrometer
1)Ionicon Analytik GmbH, Eduard- Bodem-Gasse 3, 6020 Innsbruck, Austria and 2) Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstr. 25, 6020 Innsbruck, Austria

In order to identify and quantify isomeric compounds independently in real-time, we introduce a novel approach where we integrate a fast GC column (“fastGC”) into a PTR-QiTOF instrument. The outstanding sensitivity of the new PTR-QiTOF (up to 4,700 cps/ppbv) is crucial for applications where time per analysis is limited, e.g. nosespace in food and flavor research. Particularly, in these fields the chemical environment is normally very complex so that a high selectivity is essential as well.
Analysis of Polymers, Additives and Contaminates in Medical Devices using Pyrolysis-GCMS
CDS Analytical

Pyrolysis GC-MS is a standard technique used to analyze industrial polymers. This poster will show the use of multiple temperature ramps to analyze for additives and contaminants, in addition to polymer identification, in several medical devices.
Investigating the Effects of Commercial Antimicrobial Agents on Human Corneal Epithelial Cell Membranes
SUNY University at Buffalo

Several commercial multi-purpose solutions (MPS) products contain polyhexamethylene biguanide (PHMB) and/or polyquaternium-1 (PQ-1) as antimicrobial agents. In this poster we report the effects of PHMB and PQ-1 on small unilamellar vesicles (SUV) that we have designed to mimic the average human corneal epithelial cell membrane.
Aptamer-Based Electrochemical Biosensing Platform for Detection of Hormonal Pollutants in Water
Université du Québec à Montréal, INRS-EMT

A novel detection mechanism based on aptamers has been developed to detect small molecules as hormones, antibiotics, toxins, drugs, etc. For first time, an aptasensor to detect progesterone has been developed.
An investigation into the effects of aging on automotive bumper samples by xylene soluble flow injection polymer analysis (XS-FIPA)
Malvern Instruments Ltd

This poster describes the use of flow injection polymer analysis (FIPA) as an analytical tool for xylene soluble (XS) determination with quick and easy simultaneous measurements of molecular weight (MW), intrinsic viscosity (IV) and XS%. The technique was applied to automotive bumper samples which had undergone an aging test. The results from the XS-FIPA technique highlight the differences caused by the aging process.
Application Notes
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform
AB SCIEX

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry
AB SCIEX

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
Can LC-MS/MS Be Used in Horse Meat Detection?
AB SCIEX

Following the Food Standards Agency’s announcement that horse and pig DNA had been identified in beef products sold by several supermarket chains, further testing has revealed widespread incidences of such contamination. This application note details a rapid, robust, sensitive and specific LC-MS/MS assay for the simultaneous detection of horse meat and the banned substance phenylbutazone (BUTE).
Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples
AB SCIEX

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.
Automated Liquid-liquid Extraction of 25-Hydroxy Vitamin D from Serum and Preparation for LC/MC Analysis Using the Hamilton Robotics Microlab STARlet Workstation
Hamilton

This application note demonstrates the automation capabilities of Hamilton Robotics’ Microlab STARlet and how it can be used to prepare clinical serum samples for Vitamin D analysis quickly, reliably and cost effectively.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation

In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
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