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Webcast - Simplifying Complexity: New MS Reagents that Improve Proteome Depth, Quantification, and ThroughputSimplifying Complexity: New MS Reagents that Improve Proteome Depth, Quantification, and Throughput
In this talk John C. Rogers, Ph. D., Senior R&D Manager, Mass Spectrometry Reagents, Thermo Scientific Pierce Protein Research, will discuss proteome complexity and the need for sample fractionation and peptide quantitation.
Webcast - Plasma Vitronectin Predicts Response to Fluoropyrimidine-oxaliplatin (FOLFOX) Chemotherapy in Metastatic Colorectal Cancer Plasma Vitronectin Predicts Response to Fluoropyrimidine-oxaliplatin (FOLFOX) Chemotherapy in Metastatic Colorectal Cancer
Sarah Hayes, University of Sydney, speaking at Diagnostics & Biomarkers 2015.

Market Reports
Label-Free Binding Analysis Trends 2014

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Mass Spectrometry for Clinical Diagnostics Applications 2013 Focus Report

This report from SELECTBIO addresses a number of topics including, market segmentation, market landscape, and mass spectrometry products currently on the market as well as in development.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights

Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights

There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Scientific News
Featured Article
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.

New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
Acetaldehyde and Formaldehyde Content in Foods
Korean researchers have determined the content of the toxic and carcinogenic aldehydes, acetaldehyde and formaldehyde, in a variety of food groups.
Combining the Power of Mass Spectrometry & Microscopy
A tool that provides world-class microscopy and spatially resolved chemical analysis shows considerable promise for advancing a number of areas of study, including chemical science, pharmaceutical development and disease progression.
Increasing Vitamin D Supplementation
New study from ETH Zurich finds that elderly women should consume more vitamin D than previously recommended during the winter months.
Advancing Lithium-Ion Battery Research
The increasing number of components in a lithium-ion battery makes it essential to use a variety of analytical methods to attain complete characterization.
Clearest Ever Images of Enzyme that Plays Key Roles in Aging, Cancer
UCLA-led research on telomerase could lead to new strategies for treating disease
Fruit Fly Pheromone Flags Great Real Estate for Starting a Family
Finding could aid efforts to control mosquito-borne diseases like malaria by manipulating odorants
Education and Expense: The Barriers to Mass Spectrometry in Clinical Laboratories?
Here we examine the perceived barriers to mass spec in clinical laboratories and explore the possible drivers behind the recent shift in uptake of the technology in clinical settings.
Business News
R&D 100 Award Goes to Waters ionKey/MS System
Novel approach is enhancing the sensitivity of bioanalytical, biomarker validation, pharmacokinetic and food research LC/MS analyses.
Agilent Completes Acquisition of Seahorse Bioscience
Agilent has completed the acquisition of Seahorse Bioscience, a leader in providing instruments and assay kits for measuring cell metabolism and bioenergetics.
SCIEX, University of Manchester Partner
SWATH® Acquisition-based next-generation proteomics technology promises to make industrial proteomics a reality.
SIMM Honored by Waters Centers of Innovation Program
Research Center for traditional Chinese medicine modernization recognized for advancing quality control authentication and profiling methods.
Sigma-Aldrich Announces Agreement on Assets Sale to Honeywell
Asset sale includes Sigma-Aldrich-branded solvents and inorganics business in the EEA.
SCIEX Partners with the Paulovich Lab at Fred Hutchinson Cancer Research Center
Collaboration targets research reproducibility crisis with highly validated multiplex quantitation assays.
Dr. Vladimir Shulaev Joins PREMIER Biosoft Scientific Advisory Board
Dr. Shulaev joins SAB to further the development of software solutions for metabolomics and lipidomics research.
Thermo Fisher Scientific Receives IVDD CE Mark for LC-MS Products
Now available to clinical laboratories in Europe for general in vitro diagnostic use.
Agilent to Acquire Seahorse Bioscience
Acquisition complements Agilent’s market-leading separations and mass spectrometry solutions, expands pharma offerings.
Phenomenex,Tecan Partner
Phenomenex, Inc. and the Tecan Group has announced a collaboration to co-market automated solid phase extraction (SPE) sample preparation solutions.

A New Proteomics Workflow for
03 Dec 2015
A New Proteomics Workflow for ...
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02 Dec 2015
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Metabomeeting 2015
07 Dec 2015
Metabomeeting 2015 ...
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CMC Strategy Forum
25 Jan 2016
CMC Strategy Forum ...
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Spice Wars- Are You Battle Ready? Analysis of Synthetic Cannabinoids via Gas Chromatography—High Resolution Time-of-Flight Mass Spectrometry
LECO Corporation, Berrien County Forensic Laboratory

-EI/CI workflow facilitates confident compound identification.
-GC-HRT and HR-CI source provides high quality, accurate mass data for:
-Database searches (NIST, Wiley, etc.)
-Formula determination (fragment, molecular, and adduct ions)
A proteomic analysis of p27kip1-binding proteins reveals a putative role in transcription regulation through RNA polymerase II interaction
1.-Department of Cell Biology, Immunology and Neurosciences, University of Barcelona-IDIBAPS, Barcelona, Spain 2.-INSERM UMR1037-Cancer Research Center of Tolouse, Universite de Tolouse, CNRS ERL5294

A proteomic analysis of p27kip1-binding proteins reveals a putative role in transcription regulation through RNA polymerase II interaction
Quantitative Analysis Of Pesticides In Quechers Extracts Using UPLC- and APGC- MS/MS
Waters Corporation, Wilmslow, SK9 4AX, United Kingdom

In this study, we demonstrate sensitive, accurate and repeatable results for the analysis of pesticides in QuEChERS extracts of a selection of
commodities below the regulatory limits.
TGA/IST16/GC/MS coupling : an advanced technique for LLDPE structure interpretation
1 SRA Instruments, 210 rue des Sources 69280 Marcy l'Etoile, France - 2 Université de Lyon, Univ. Lyon 1, CPE Lyon, CNRS UMR 5265, Laboratoire de Chimie Catalyse Polymères et Procédés (C2P2), Equipe

An innovative TGA/IST16/GC/MS coupling is presented.
Jomo Kentyatta University of Agriculture and Technology (Kenya), and Foundation of Analytical Science and Technology in Africa (UK).

From this study, the pain killers sampled were found to have large error bars suggesting that there exist counterfeit drugs in the market. The brands mostly affected for analysis of acetaminophen were panadol, action, P500, P5500, elymol and neladol. The error bars for caffeine analysis were quite low indicating that all tablets either counterfeit or original maintained the same amount of this active ingredient.
Jomo Kenyatta University of Agriculture and Technology

Generally, honey samples recorded very low concentrations of As compared to the other heavy metals determined in this study. The highest concentration of As was recorded in honey sample from Nairobi with a value of 0.03±0.01 ppm. All the values recorded were within the KEBS permitted value of 0.5 ppm in food according to Kenya Bureaue of Standards, 1996.
Prospecting For Iron and Titanium Using Termitaria
Jomo Kenyatta University of Agriculture and Technology

This study demonstrated elevated levels of the two metals (that is iron and titanium) in termitaria soil compared to the surrounding soils. Termitaria are very important bioturbators and can therefore be used as preliminary step in mineral prospecting since they provide an indication of the potential of the positive anomaly, and enables a judgment on the scale of the metal accumulation
Integrating Fluorescent Carbon Nanodot Synthesis and Optical Detection of Methylmercury
University of Vigo (Spain)

In the last years, a great interest toward development of optical nanoprobes has arisen, so fluorescent nanomaterials have been implemented in analytical systems for the detection of several species. In this work, a novel assay that integrates the synthesis of fluorescent carbon dots (CDs) and sensing within one step, for the fast, sensitive and selective detection of methylmercury is presented.
A FastGC Proton-Transfer-Reaction Quadrupole Ion Guide Time-of-Flight (PTR-QiTOF) Mass Spectrometer
1)Ionicon Analytik GmbH, Eduard- Bodem-Gasse 3, 6020 Innsbruck, Austria and 2) Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstr. 25, 6020 Innsbruck, Austria

In order to identify and quantify isomeric compounds independently in real-time, we introduce a novel approach where we integrate a fast GC column (“fastGC”) into a PTR-QiTOF instrument. The outstanding sensitivity of the new PTR-QiTOF (up to 4,700 cps/ppbv) is crucial for applications where time per analysis is limited, e.g. nosespace in food and flavor research. Particularly, in these fields the chemical environment is normally very complex so that a high selectivity is essential as well.
Analysis of Polymers, Additives and Contaminates in Medical Devices using Pyrolysis-GCMS
CDS Analytical

Pyrolysis GC-MS is a standard technique used to analyze industrial polymers. This poster will show the use of multiple temperature ramps to analyze for additives and contaminants, in addition to polymer identification, in several medical devices.
Application Notes
Automated Sample Preparation - Analysis of 25-OH-Vitamin D3 and 25-OH-Vitamin D2 by LC/MS/MS
Beckman Coulter Life Sciences

Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
Beckman Coulter Life Sciences

Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS
Beckman Coulter Life Sciences

Automating Protein Digestion for Reproducible Proteomics
Beckman Coulter Life Sciences

Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
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