Corporate Banner
Satellite Banner
Mass Spectrometry
Scientific Community
Become a Member | Sign in
Home>News>This Article

Thermo Scientific XSERIES 2 ICP-MS for Reliable and Efficient Sulfur Detection in Proteins

Published: Saturday, January 15, 2011
Last Updated: Friday, January 14, 2011
Bookmark and Share
The University of Oviedo’s analytical spectrometry research group has implemented the Thermo Scientific XSERIES 2 ICP-MS to perform sulfur detection in proteins.

Thermo Fisher Scientific Inc., has announced that the University of Oviedo’s analytical spectrometry research group has implemented the Thermo Scientific XSERIES 2 ICP-MS to perform reliable and interference-free sulfur detection in proteins.

In the past, interference from gas-based polyatomics has made the accurate determination of sulfur isotopes particularly challenging for the research group. The XSERIES 2 ICP-MS has overcome these issues, offering high levels of accuracy while also optimizing the efficiency of analyses.

The analytical spectrometry research group at the University of Oviedo in Asturias, Spain aims to solve the analytical challenges encountered by science and technology. Within this framework, a small sub-group has been established focusing on the development of inductively coupled plasma-mass spectrometry (ICP-MS) based analytical methods for the quantification of biopolymers such as DNA and proteins.

One of the principal issues faced by the group is the interference from gas-based polyatomics such as oxygen in the determination of sulfur when using a low resolution instrument. To eliminate these problems, the group selected the Thermo Scientific XSERIES 2 ICP-MS with collision/reaction cell technology (CRC).

Quantitative protein analysis is currently one of the most demanding applications in analytical chemistry. Mass spectrometric techniques such as electrospray ionization-mass spectrometry (ESI-MS) and matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) have traditionally played a key role in protein analysis. However, the potential of ICP-MS has recently been recognized for the determination of proteins.

Although ICP-MS detection does not provide any structural information, its outstanding capability to quantify most of the elements proves valuable for accurate protein quantification. Keeping pace with the latest technological developments, the University of Oviedo’s research group has coupled the XSERIES 2 ICP-MS with a reversed-phase capillary liquid chromatography (μLC) system to facilitate precise determination of sulfur isotopes in standard proteins.

Dr. Jörg Bettmer of the University of Oviedo’s analytical spectrometry research group comments, “The Thermo Scientific XSERIES 2 ICP-MS was chosen because no other quadrupole-based system matches its capabilities in terms of accuracy, reliability and overall efficiency. The implementation of the instrument has allowed us to achieve reliable, interference-free detection of sulfur isotopes. It has enabled us to determine sulfur-containing standard proteins in an accurate and efficient manner that had not been previously possible.”

The XSERIES 2 offers outstanding productivity in a quadrupole ICP-MS for both routine and high-performance analytical applications. By using the system, laboratories can achieve their analytical objectives faster, with greater confidence and less hands-on time from the operator.
The innovative ion lens design of the instrument enables simple field upgrade to collision cell technology (CCT) performance without affecting the normal (non-CCT mode) sensitivity or background. The cell is also compatible with a range of reactive gases, such as pure oxygen for interference suppression in challenging matrices.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Fisher Scientific Receives IVDD CE Mark for LC-MS Products
Now available to clinical laboratories in Europe for general in vitro diagnostic use.
Friday, September 11, 2015
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Thursday, October 23, 2014
Thermo Fisher, NRLs Team to Confirm Dioxins in Feed and Food
Thermo Fisher Scientific worked closely with national reference labs (NRLs) in the European Union to support the development of new regulation.
Monday, September 08, 2014
Thermo Supports Distinguished Analytical Chemistry Seminar Series at NC State
An endowment established by the company provides opportunities to attend presentations by leading analytical chemistry authorities.
Tuesday, August 19, 2014
Reimagining UHPLC
To learn more about the new Vanquish UHPLC system from Thermo Fisher Scientific we spoke to Wulff Niedner, Director of HPLC Product Marketing.
Thursday, July 17, 2014
Thermo Registers San Jose Facility with FDA
The site has established a quality system in accordance with the FDA Quality System Regulations to design and manufacture devices for analyzing samples from patients for in vitro diagnostic use.
Monday, June 16, 2014
Thermo Fisher, BioAnalytix Collaborate
Collaboration to develop advanced biopharmaceutical analysis workflows.
Thursday, June 12, 2014
Thermo, Nuclea Biotechnologies Collaborate to Develop Diabetes Markers
Companies pooling their expertise to develop novel multiplexed research methods for high-throughput quantification of native insulin and its therapeutic analogs.
Monday, June 02, 2014
Thermo, Evans Analytical Group Form Joint Effort to Expand GDMS Applications
Companies team up to apply pulsed glow discharge mass spectrometry to analysis of non-conductive materials, depth profiling.
Thursday, May 15, 2014
Thermo Reports 22% Revenue Rise in Q1 2014
Results include the addition of Life Technologies as of February 4, 2014, and exclude the previously announced related divestitures as of March 22, 2014.
Wednesday, April 23, 2014
Thermo, Harvard Establish Center for Multiplexed Proteomics
Thermo Fisher Scientific Center for Multiplexed Proteomics at Harvard Medical School aims to expedite understanding of complex disease mechanisms.
Thursday, March 20, 2014
Thermo Completes Life Tech Acquisition
The completion of the transaction follows the receipt of all required regulatory approvals.
Tuesday, February 04, 2014
Thermo Reports 6% Q4 Revenue Growth
Thermo Fisher Scientific Inc. reported its financial results for the fourth quarter and full year ended December 31, 2013.
Friday, January 31, 2014
Biosimilar Characterization R&D Facility Opens in Austria
University of Salzburg, Sandoz and Thermo Fisher Scientific collaborate to advance protein-based pharmaceutical development, production, QA/QC.
Wednesday, October 23, 2013
Thermo Fisher Scientific and the DTU Form Systems Biology Collaboration
Orbitrap Fusion Tribrid LC-MS technology to power new cellular signaling network research.
Monday, September 02, 2013
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
Acetaldehyde and Formaldehyde Content in Foods
Korean researchers have determined the content of the toxic and carcinogenic aldehydes, acetaldehyde and formaldehyde, in a variety of food groups.
Combining the Power of Mass Spectrometry & Microscopy
A tool that provides world-class microscopy and spatially resolved chemical analysis shows considerable promise for advancing a number of areas of study, including chemical science, pharmaceutical development and disease progression.
Increasing Vitamin D Supplementation
New study from ETH Zurich finds that elderly women should consume more vitamin D than previously recommended during the winter months.
Advancing Lithium-Ion Battery Research
The increasing number of components in a lithium-ion battery makes it essential to use a variety of analytical methods to attain complete characterization.
Clearest Ever Images of Enzyme that Plays Key Roles in Aging, Cancer
UCLA-led research on telomerase could lead to new strategies for treating disease
Fruit Fly Pheromone Flags Great Real Estate for Starting a Family
Finding could aid efforts to control mosquito-borne diseases like malaria by manipulating odorants
Education and Expense: The Barriers to Mass Spectrometry in Clinical Laboratories?
Here we examine the perceived barriers to mass spec in clinical laboratories and explore the possible drivers behind the recent shift in uptake of the technology in clinical settings.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos