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Cerilliant Introduces Aldosterone Certified Spiking Solution® for LC-MS/MS Testing

Published: Thursday, April 05, 2012
Last Updated: Thursday, April 05, 2012
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This certified reference solution is suitable for use as a critical starting material in preparation of linearity standards, calibrators, or controls for aldosterone testing by LC-MS/MS.

Cerilliant introduces a Certified Spiking Solution® of aldosterone at a concentration of 100 µg/mL in acetonitrile.

The Endocrine Society recommends using the aldosterone to renin ratio (ARR) for primary aldosteronism (PA) screening of patients at a high risk for hypertension1. Ensuring accurate, consistent, and reproducible ARR test results is critical not only for proper diagnosis and treatment of PA but also for ongoing management of the condition.  Test results are only as accurate as the reference, therefore any significant difference in purity of the aldosterone reference material from lot to lot could increase variability and impact the potential for a false-positive or false-negative diagnosis.

It is important to use Certified Reference Materials (CRM’s) for clinical applications, rather than research chemicals. Because research grade chemicals are not produced to the same standards and specifications as Certified Reference Materials (CRMs), use in clinical testing applications can lead to errors in quantitation, with potentially serious therapeutic implications.  According Uma Sreenivasan, PhD and Chief Science Advisor at Cerilliant, “the specifications and design for research chemicals are very different from that of CRMs which are synthesized to the highest quality, thoroughly characterized and fully certified to ensure suitability for use and lot-to-lot consistency. Commercial sources of aldosterone also vary in purity. In the development of this standard, we paid great attention to the purification process and characterization of the product to design a high purity material for clinical applications.”

Starting with Cerilliant Certified Spiking Solutions® eliminates variability that may arise from differences in weighing of compounds or their purity from lot to lot. Cerilliant solutions begin with extensive characterization of the neat materials to determine an accurate weighing adjustment followed by gravimetric preparation using validated processes and flame sealing under argon into ampoules for long-term shelf-life. Cerilliant Snap-N-Spike® solutions are prepared and certified to the highest industry standards including ISO Guide 34 and ISO 17025.

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