Probing Conformational Changes of Human DNA Topoisomerase IIa by Pulse-Alkylation Mass Spectrometry
Published: Monday, June 18, 2012 Last Updated: Monday, June 18, 2012
Utilizing pulse-alkylation with mass spectrometric analysis, researchers from Duke University Medical Center could differentiate the levels of alkylating reactivities of cysteines in hsTop2a and probe the protein dynamics.
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