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Bruker Launches High-Performance LC Triple Quadrupole Mass Spectrometers

Published: Thursday, September 06, 2012
Last Updated: Thursday, September 06, 2012
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Game-changing EVOQ™ Qube™ and EVOQ Elite LC-TQ systems unveiled at JASIS.

At the 2012 Japan Analytical Scientific Instruments Show (JASIS), Bruker today launches two game-changing LC-triple quadrupole (LC-TQ) mass spectrometers, the high-performance EVOQ Qube™ and the ultra-high sensitivity EVOQ Elite, which are setting new standards for analytical performance and quantitative robustness.  As with Bruker’s very successful SCION GC-TQ platform, introduced in 2011, the EVOQ series is targeted at LC-TQ performance leadership and delivers major advances in robustness, ease of method developments and productivity.

The EVOQ LC-TQ systems introduced today incorporate Bruker’s new Advance™ Ultra-High Pressure Liquid Chromatography (UHPLC) systems. In addition, the EVOQ platform features several major innovations:

• The industry’s first Vacuum-Insulated Probe (VIP) heated electrospray technology preserves and ionizes thermally fragile molecules with outstanding sensitivity.
• The Active Exhaust atmospheric pressure ionization source with a robust orifice vacuum interface significantly enhances quantitative robustness for difficult samples.  
• The novel, ‘flat-tuning’, proprietary Interlaced Quadrupole Dual Funnel (IQ-DF™) maximizes sensitivity.
• Novel PACERTM software enables ‘exception based data-review’, a revolutionary feature that significantly reduces the error rate for quantitative analysis.

Bruker’s patented lens-free triple-quad mass filter design, which enhances MRM performance, is standard on all EVOQ systems, making the EVOQ LC-TQ inherently easier to use and maintain. Other high-performance TQ features include Bruker’s unique Compound Based Scanning (CBS) technology, the novel VIP heated-ESI and APCI ion sources, fast 14,000 amu/sec scan speed and 25 milliseconds positive/negative ion switching, all for leading-edge TQ performance and analytical power.

Jonathan McNally, EVOQ Product Manager, said: “Our intention was to make the EVOQ LC-TQ very intuitive to use, whether the users are analyzing pesticides in water using our new Advance UHPLC with on-line extraction (OLE) capability for high volume injections, or quantifying peptides in plasma.

Our goal is to allow the user to focus on solving the analytical problem, and not be distracted by the instrument parameter operation. The EVOQ greatly simplifies MRM-based quantitation with Bruker’s unique Compound Based Scanning (CBS), which makes MRM methods development trivial, and MS/MS as easy to use and deploy as single quadrupole mass spectrometry.”

Collin D’Silva, Bruker CAM Division President, added: “Our customers need to run more samples, spend less time cleaning and re-tuning instruments, and use software to minimize errors associated with the daily review of thousands of chromatograms. The EVOQ with PACER software delivers significant value to a laboratory whose core focus is providing time-sensitive quantitative data.”

The Advance HPLC, UHPLC, and the UHPLC-OLE products offer ultra-low dead-volume which enables excellent reproducibility at analytical flow-rates, an integrated column-oven, and bench-space savings.  Paired with the industry workhorse CTC auto-sampler, the Advance LC portfolio delivers precision and accuracy required for sustained, high-sensitivity LC-MRM quantitative analysis.

Rohan Thakur, Ph.D., Vice President and General Manager of Bruker’s Quadrupole MS Business, concluded: “The EVOQ LC-TQ platform delivers on Bruker’s philosophy of providing innovative, compact, easy-to-use and performance-leading solutions that customers value for their daily work.  We believe that the novel EVOQ triple-quad platform with its many true innovations, outstanding sensitivity and ease-of-use breakthroughs will leapfrog traditional TQ designs as the new performance leader in this large market.”

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