Corporate Banner
Satellite Banner
Mass Spectrometry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cerilliant Offers New Certified Spiking Solutions®

Published: Thursday, November 29, 2012
Last Updated: Thursday, November 29, 2012
Bookmark and Share
Preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LC/MS or GC/MS.

Cerilliant has introduced new Certified Spiking Solutions® of nicotine metabolites norcotinine and trans-3-hydroxycotinine as well as nicotine nitrosamines NNN, NNK, and NAB at concentrations of 1.0 mg/mL in methanol for each solution standard.

These certified reference solutions can be used as Snap-N-Spike® starting materials in the laboratory’s matrix of choice for preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LC/MS or GC/MS.

Nicotine biomarkers are commonly monitored in patients who smoke cigarettes, use other nicotine products such as nicotine gum and electronic cigarettes, or are exposed to environmental tobacco smoke.

Accurate patient results in clinical and diagnostic testing of nicotine use depend on accurate and consistent Certified Reference Materials for the numerous nicotine metabolites.

Neat material handling of nicotine analogs and their preparation as certified reference solutions offer significant challenges to the laboratory due to high toxicity of the neat materials and their sensitivity to air and light.

Cerilliant’s validated process includes manufacturing controls for sensitive compounds such as raw material handling and solution preparation under inert conditions and flame-sealing of ampoules under argon to minimize degradation and promote long-term shelf life.

Toxic materials are handled in isolation chambers and are gravimetrically prepared using precision balances which have been qualified to ensure minimal uncertainty.

“Protection of both production staff and the correct handling of these highly toxic neat materials are of paramount importance in the preparation of these solution standards. Consequently the formulation of the nicotine metabolites is limited to staff who have received and passed the appropriated level of internal training through our proficiency testing program to ensure proper use of equipment and accurate preparation using the glove boxes,” added Gregory Kirkovits, PhD, manager of the Standards & Packaging group.

Cerilliant’s latest nicotine metabolite and nitrosamine products complement their current offering of Certified Spiking Solutions® for nicotine, including anabasine, cotinine, and nornicotine and their internal standards, all offered at concentrations suitable for dilution to working levels in the laboratory’s matrix of choice.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Could a simple saliva test detect Alzheimer's?
Researchers have presented findings suggesting that a simple, non-invasive diagnostic for Alzheimer's could be within reach.
Facebook for the Proteome
Researchers have developed a network for describing protein-protein interactions that can then be used to examine protein interactions that may have biological or clinical significance.
Researchers Reveal Elusive Molecule
A long-standing chemistry puzzle has been solved, with potential implications ranging from industrial processes to atmospheric chemistry.
‘Atomic Detectives’ Scientists that Keep us Safe from Radioactive Criminality
Stephan Richter from the JRC-Institute for Reference Materials and Measurements has examined the merits and limitations of available mass spectrometric instrumentations for nuclear safeguards applications.
MSU Scientists Uncover a ‘Funky Cofactor’
While examining the chemical reactions of bacterial cells in a lab at Michigan State University, researchers found an unusually complex molecule in a protein that completes a simple process.
Aluminum Clusters Shut Down Molecular Fuel Factory
3-D images give clues to extending catalyst life.
Chemists Design a Quantum-Dot Spectrometer
New instrument is small enough to function within a smartphone, enabling portable light analysis.
Creating Bacterial ‘Fight Clubs’ to Discover New Drugs
Creating bacterial “fight clubs” is an effective way to find new drugs from natural sources.
Informatics Tool Helps Scientists Prioritize Protein Modification Research
Researchers have developed a new informatics technology that analyzes existing data repositories of protein modifications and 3D protein structures to help scientists identify and target research on "hotspots" most likely to be important for biological function.
Iron: A Biological Element?
Study shows findings which have meaning for fields as diverse as mining and the search for life in space.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!