Corporate Banner
Satellite Banner
Mass Spectrometry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cerilliant Introduces 13C-Labeled Internal Standards for Thyroid Hormone Testing by LC-MS/MS

Published: Tuesday, January 29, 2013
Last Updated: Tuesday, January 29, 2013
Bookmark and Share
The products offer clinical and endocrinology labs the full range of stable-labeled internal standards necessary for accurate quantitation of T4, T3, and reverse T3 using LC-MS/MS methods.

Cerilliant introduces Certified Spiking Solutions® for use in preparation of calibrators and controls of T4-13C6, T3-13C6, and reverse T3-13C6 for monitoring free and total thyroid hormone levels in serum or plasma by LC-MS/MS. Cerilliant’s new thyroid hormone internal standards complement their current offering of native T4, T3, and reverse T3 Certified Reference Materials (CRMs) at concentrations suitable for dilution to the desired concentration in the laboratory’s matrix of choice. 

Disorders of thyroid metabolism affect millions of patients worldwide. Clinical diagnosis and treatment requires testing and monitoring of patient thyroid hormone levels. Currently most thyroid hormone assays are by radioimmunoassay (RIA) which has limited shelf life and lack specificity. In recent years there has been significant push to develop LC-MS/MS methods for quantitation of thyroid hormones with the potential for higher accuracy, better specificity, and the ability to quantitate the different thyroid hormones separately. The choice of internal standard in these LC-MS/MS methods is critical for accurate quantitation of analytes, especially those at low concentrations or where matrix effects are an important consideration such as in thyroid analysis. “Using 13C-labeled internal standards for thyroid analysis can eliminate potential issues such as isotopic exchange and minimize separation of later-eluting analytes from a higher substituted deuterium-labeled internal standard.” comments Josh Cooper, PhD and Cerilliant analytical scientist specializing in LC-MS/MS analysis. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
HIV Particles Used to Trap Intact Mammalian Protein Complexes
Belgian scientists from VIB and UGent developed Virotrap, a viral particle sorting approach for purifying protein complexes under native conditions.
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
Coding and Computers Help Spot Methane, Explosives
Coded apertures improve and shrink mass spectrometers for field use.
Why Bearcats Smell Like Buttered Popcorn
Researchers pinpoint chemical compound that gives rare animal its popcorn-like scent.
UCSD Scientists Receive NIH Grant to Combat Antibiotic Resistance
Interdisciplinary program will use systems biology approaches to understand how antibiotics work in concert with patient’s immune system.
Virus Causing Tilapia Die-Offs Identified
Discovery of the virus causing Tilapia die-offs in Israel and Ecuador points the way to protecting a fish that feeds multitudes.
Novel Collagen Fingerprinting Identifies A Neanderthal
Study from the universities of Oxford and Manchester uses ZooMS technique to identify traces of an extinct human.
Hope for Combating Muscular Dystrophy
Decoding a sugar molecule and identifying a mechanism linking it to MS could help in the development of therapy for the disease.
Decoding Sugar Molecules Offers New Key For Combating Muscular Dystrophy
Japanese scientists find a rare sugar unit called ribitol 5-phosphate within the sugar molecules on the surface of muscle cells. Mutations in 3 genes linked to muscular dystrophy affect the creation of this sugar molecule.
A Vision for Precision Medicine
The University of Manchester and the University of Dundee partner to share disease screening data.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!