Corporate Banner
Satellite Banner
Mass Spectrometry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Article on the Dangers of Chloramphenicol in Milk and Its Detection

Published: Tuesday, July 02, 2013
Last Updated: Tuesday, July 02, 2013
Bookmark and Share
An article exploring the dangers posed by chloramphenicol (CAP) in milk and its detection using the EVOQ Qube LC-TQ MS/MS is described.

The article entitled “The Danger of Chloramphenicol in Milk” from the Bruker Chemical & Applied Markets (CAM) division has been published in Food Safety Magazine online. Authored by Bruker specialists in liquid chromatography, the article examines the dangerous effects of CAP in contaminated food and how the high sensitivity EVOQ can detect levels as low as 0.02 ppb in milk, far exceeding minimum required performance levels (MRPL) set by EU guidelines.
 
Chloramphenicol is a naturally occurring broad spectrum antibiotic, initially employed as a first line of treatment for typhoid. Although CAP is still commonly prescribed as an optical treatment in the EU, its use is otherwise severely limited. This is in part due to the risk the drug poses to infants, who lack the fully developed liver enzymes to metabolize the drug. Ingestion of CAP can thus cause potentially fatal Gray Baby syndrome, and has also been linked to acute lymphotic leukemia and bone marrow suppression.
 
Consequently in the EU chloramphenicol is banned from use in veterinary medicine and its presence in food products such as milk is strictly prohibited. Regulations state that methods used for the detection of CAP in milk must meet or exceed the MRPL of 0.3 ppb. A case study was carried out on the EVOQ Qube LC-TQ MS/MS, designed for maximum sensitivity in high throughput applications. The EVOQ was able to quantify concentrations as low as 0.2 ppb, easily exceeding EU guidelines, while maintaining consistent ion rations from 0.05 to 1.0 ppb.
 
“Routine food testing requires sustained high sensitivity and the fastest possible turnaround, since time can be critical,” Meredith Conoley, Marketing Director for Bruker CAM, said. “The EVOQ was specifically designed with new technological innovations to meet these criteria. The Active Exhaust prevents the recirculation of nebulized gases to reduce chemical build up, while the Orifice Interface is continually flushed to keep it clean and reduce instrument downtime. PACER exception based data review software moreover provides the fastest sample to report time possible. This high performance instrument offers advantages for many application areas, including environmental testing and forensics.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Determination of 13 Organic Toxicants in Human Blood
Researchers have utilised liquid-liquid extraction coupling HPLC-MS/MS to identify and quantify organic toxicants in human blood.
Accessing Metabolic Information with Mass Spec
Scientists at the Helmholtz Zentrum München have developed a new mass spectrometry imaging method which, for the first time, makes it possible to analyze hundreds of metabolites in fixed tissue samples.
Unravelling the Roots of Insect’s Waterproof Coating
Researchers have identified the genes that control cuticular lipid production in Drosophila, by performing an RNAi screen and using Direct Analysis in Real Time and GC-MS.
Massive Helium Discovery a "Game Changer" for Medical Industry
A new development is gas exploration has yielded the discovery of a huge helium gas field, which could help relieve the dwindling supply.
Unidentified Spectra Detector
New algorithm clusters over 250 million spectra for analysis, such that millions of unidentified peptide sequences can be recognised.
Making Metabolite Identification More Efficient
Metasense combines the industry's most-comprehensive metabolic transformation prediction with efficient analysis of LC/MS analytical measurements to identify, visualize, and report chemical biotransformations.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
A New Tool Brings Personalized Medicine Closer
Scientists from EPFL and ETHZ have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!