Corporate Banner
Satellite Banner
Mass Spectrometry
Scientific Community
Become a Member | Sign in
Home>News>This Article

Shimadzu HPLCs Used for Finding Cancer Treatment

Published: Thursday, November 09, 2006
Last Updated: Thursday, November 09, 2006
Bookmark and Share
Researchers are using LC10 Vp series and Prominence high performance liquid chromatography systems.

Researchers at the University of Manchester, Wolfson Molecular Imaging Centre, UK, have announced that they are using Shimadzu instruments to obtain proof of concept measurements for the mode of action and efficacy of new drugs to treat cancer and brain disorders.

They are using four LC10 Vp series and four Prominence high performance liquid chromatography (HPLC) systems, complementing positron emission tomography (PET) technology in their work on drug metabolite analysis.

"We are labelling novel drug candidate molecules with positron-emitting radioisotopes to inject into human volunteers and track using PET scanners," explained Dr Adam McMahon, Team Leader in Radio Analytical and Synthetic Radiochemistry.

"Before injection of the drug we use an LC10 Vp series to perform rapid and reliable checks for both chemical and radiant purity of the labelled molecules and, following injection, the patient's blood samples are analysed by the other HPLC systems to study metabolites carrying the radiotracer."

"Two of the Prominence systems are reserved for method development and for LC/MS studies."

"Using these instruments, we can see if a molecule might be a potentially successful drug at these early stages of drug development, before committing to further investment in major clinical trials."

Dr McMahon concluded, "The Shimadzu HPLC systems have great robustness and reliability, which is important because it is critical to have reproducible results."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Shimadzu, Indigo BioSystems Announce Partnership
The companies will leverage the power of ASCENT™ clinical solutions on ultra-fast mass spectrometry platforms.
Monday, June 16, 2014
Shimadzu Corporation, MacCoss Lab of Biological Mass Spectrometry, UW Collaborate
The companies will leverage the power of ASCENT™ clinical solutions on ultra-fast mass spectrometry platforms.
Monday, June 16, 2014
Shimadzu Registers HPLC and LCMS Instruments as Class I Medical Devices with FDA
Products are the first Shimadzu analytical instruments registered with the FDA as medical devices.
Tuesday, April 01, 2014
Shimadzu Establishes Latin American Subsidiary
Uruguayan subsidiary will strengthen company's sales and distribution whilst providing better support for customers and distributors in Central and South America.
Tuesday, November 12, 2013
Shimadzu Achieves ISO 13485 Certification for US LC-MS Facility
ISO 13485 is the globally recognized international quality management standard for medical equipment.
Wednesday, September 25, 2013
Shimadzu UK Grows Sales Orders by 30%!
Company has achieved sales order growth across many products in the Shimadzu range.
Tuesday, May 07, 2013
Shimadzu and The University of Texas Form Shimadzu Center for Advanced Analytical Chemistry
Located in the university’s Chemistry & Physics Building, the center contains $6 million of chromatography, mass spectrometry and spectroscopy equipment, which is the largest installation of Shimadzu analytical instrumentation in the Western Hemisphere.
Tuesday, April 10, 2012
Shimadzu UK Opens Evaluation Laboratory Centre to Promote Excellence in Analytical Instrumentation
New 1500m² world-class product evaluation laboratory facility at UK headquarters in Buckinghamshire.
Wednesday, July 13, 2011
Shimadzu, Ceres Nanosciences and Nonlinear Dynamics Introduce Nanotrap™ Biomarker Discovery Platform
Shimadzu Scientific Instruments has partnered with Ceres Nanosciences and Nonlinear Dynamics to bring the future of biomarker discovery to laboratory researchers.
Tuesday, March 16, 2010
Shimadzu and Phenomenome Discoveries Announce Exclusive Collaboration
Shimadzu and PDI will develop software tools for global profiling using high mass accuracy MSn data.
Monday, July 02, 2007
Shimadzu Assumes Responsibilities for X-ray Spectrometer Business
Shimadzu transfers the X-ray spectrometer business from Kratos Analytical to SSI, which will handle sales and service of X-ray spectrometers in US, Canada, and Mexico.
Wednesday, March 07, 2007
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
Acetaldehyde and Formaldehyde Content in Foods
Korean researchers have determined the content of the toxic and carcinogenic aldehydes, acetaldehyde and formaldehyde, in a variety of food groups.
Combining the Power of Mass Spectrometry & Microscopy
A tool that provides world-class microscopy and spatially resolved chemical analysis shows considerable promise for advancing a number of areas of study, including chemical science, pharmaceutical development and disease progression.
Increasing Vitamin D Supplementation
New study from ETH Zurich finds that elderly women should consume more vitamin D than previously recommended during the winter months.
Advancing Lithium-Ion Battery Research
The increasing number of components in a lithium-ion battery makes it essential to use a variety of analytical methods to attain complete characterization.
Clearest Ever Images of Enzyme that Plays Key Roles in Aging, Cancer
UCLA-led research on telomerase could lead to new strategies for treating disease
Fruit Fly Pheromone Flags Great Real Estate for Starting a Family
Finding could aid efforts to control mosquito-borne diseases like malaria by manipulating odorants
Education and Expense: The Barriers to Mass Spectrometry in Clinical Laboratories?
Here we examine the perceived barriers to mass spec in clinical laboratories and explore the possible drivers behind the recent shift in uptake of the technology in clinical settings.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos