Posters

Dispersants are plasticizers commonly used to prevent clumping and help dissipate oil slicks. In this work, we used GC/MS and LC-MS/ MS to detect and indentify two of the most widely used dispersants (Corexit 9527 and 9500).

Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.

The European Union-Reference Laboratory for Mycotoxins at the Institute of Reference Materials and Measurements of the Joint Research Centers of the European Commission regularly conducts proficiency tests to assess the measurement capabilities of the National Reference Laboratories of the EU-Member States.

This poster reports the development of a triple ionization source consisting of ESI, APCI and APPI sources. The source uses two probes, one for ESI and a nebulizer/vaporizer for APCI and APPI.

The objectives of the work detailed in this poster was to explore dual dopant approach to maximizing APPI sensitivity for simultaneous analysis of low and high proton affinity compounds.

Recent developments of Liquid Chromatography instrumentation, such as UHPLC coupled with mass spectrometry, have increased the separation efficiency and sensitivity. Unfortunately, there are some unwelcome consequences. One of these is the detection of trace contamination in the solvents used to prepare mobile phases. The aim of this work was to design a cartridge which produces high water quality for very sensitive LC-MS applications.

Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.

Historically ion chromatography (IC) using conductivity detection has been successfully used for the analysis of ionic (e.g., anions and cations) and polar substances (e.g., organic acids or sugars). However, due to current toxicity concerns, analyses in complex matrices require improved sensitivities and selectivities.

The sequence-specific cleavage of the peptide bond is a crucial procedure in protein engineering and purification. The extreme stability of this bond, with half-life for spontaneous hydrolysis estimated as 350-600 years at neutral pH and room temperature, limits the range of appropriate cleavage reagents.