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Monday, December 22, 2014
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Metabolism of Eight Model Pharmaceutical Compounds in Rat and Human HepatoPac Versus Liver Microsomes and Suspension Hepatocyte Platforms
Julius O. Enoru, William DeMaio, Adiba Watanyar, Kenneth Draper, Amanda Moore & Okey Ukairo

This poster presents our comparative metabolite profiling analysis of eight model pharmaceutical compounds with various biotransformation reactions using a functionally stable model of primary hepatocytes [micropatterned co-cultures (MPCCs)] in parallel with the traditional liver microsomal and suspension hepatocyte systems.

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MsCompare: An Untargeted LC & GC/MS Metabolomics Platform for Quality Control, Precise Deconvolution and Data Analysis
Marco Ruijken

A GC/MS or LC/MS workflow for Metabolomics applications includes a number of distinct steps: experimental design, sampling, sample preparation, data acquisition, data processing, deconvolution, identification and data interpretation.

The MsXelerator software includes Quality Control procedures and Analysis of Variance (ANOVA) to properly control each step in this workflow and to obtain reliable results for both quantitation and identification.

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Searching for Urinary Biomarkers of Exposure to Heterocyclic Amines (HCAs)
Rosa Busquets, Henrik L. Frandsen, Kerstin Skog

Heterocyclic amines (HCAs) are foodborne carcinogens present in cooked meat and fish, mainly. Metabolites of HCAs have been determined in urine from volunteers following a controlled meal.

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Metabolic Stability Assay Using Human Hepatocyte Co-cultures and Integrated Qualitative/Quantitative High Resolution Mass Spectrometry
Alex Zang, Ragu Ramanathan, Cornelia Smith, Caroline Lee, Helen Shen, and Zamas Lam

Purpose: To investigate Sequential Window Acquisition of all Theoretical fragment ion spectra (SWATH™) based integrated qualitative and quantitative (qual/quant) assay for simultaneous metabolic stability and metabolite profiling assessments.

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In Vitro Species Comparison Using Long-Term Hepatocyte Co-Cultures Model and Highly Sensitive UHPLC-QTOF-MS with SWATH Analysis
Jian Yu; Ragu Ramanathan; Cornelia Smith; Caroline Lee; Helen Shen; Zamas Lam

Purpose: To develop a reliable, quicker, and cost-saving in vitro method to accurately predict major human metabolite profile in vivo and to de-risk disproportional or unique human metabolites before a drug candidate nomination

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Metabolite Profiling Using Human Hepatocyte Co-cultures and UHPLC-QTOF-MS with Data Independent MS/MS
Ronghua Wang, Ragu Ramanathan, Cornelia Smith, Caroline Lee, Helen Shen, and Zamas Lam

Purpose
To investigate a high throughput workflow for metabolite profiling using a novel human in vitro system and advanced UHPLC-MS/MS techniques to accurately predict human metabolite profile in vivo.

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Mixtures Analysis of Complex Mixtures
Michael Bernstein; Carlos Cobas; Santi Domínguez; Manuel Pérez; Agustín Barba

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.

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A Complete Wine Analysis Using Multiplets Detection
Dr Michael Bernstein1; Agustín Barba1; Dr Susanne Klein2; Dr Andrea Dreiseitel2; Daniel Heidger2 and Volker Heidger2

NMR mixtures analysis can be used to determine the concentration of key components in wine. Here we show the analysis using SMA from Mestrelab.

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DPPH scavenging activities of selected flavonoids and their mixtures
Brachos D.(1)

The aim is to identify the ati-oxidant activity of selected flavonoids (quercetin, luteolin and galangin) and their mixtures using DPPH method including their synergistic or antagonistic interactions.

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Showing Results 11 - 20 of 118
Scientific News
Cells Build 'Cupboards' To Store Metals
Lawrence Livermore researchers have discovered that cells of the alga Chlamydomonas Reinhardti build a “pantry” to store metal and maintain equilibrium.
Non-Gluten Proteins as Targets of Immune Response to Wheat in Celiac Disease
The results were reported online in the Journal of Proteome Research.
Turkeys may be Lifesavers
Antibiotic to target staph infections, strep, comes from good bacteria in turkeys.
Did You Hear The One About The Two Businessmen On A Plane?
EquipNet’s vision ‘to revolutionize the way companies manage their surplus assets’ was first conceived at 30,000 feet somewhere between Chicago and Boston in 1999. Here we learn more about the company's first 15 years.
Proteomics for Systems Toxicology
MS-based proteomics is maturing into a robust technology for the measurement of proteome-wide exposure effects.
Charge-Tagged Proline-Based Organocatalyst for Mechanistic Studies Using ESI-MS
In a comparative continous flow ESI-MS study, researchers use a new charged catalyst and neutral L-proline to investigate the proline-catalyzed inverse crossed aldol reaction of aldehydes with diethyl ketomalonate.
Could Non-gluten Proteins Play a Role in Celiac Disease?
Scientists are reporting in ACS’ Journal of Proteome Research that people with the disease also have reactions to non-gluten wheat proteins.
Mass Spec Sample Prep Cut From Days to Minutes
The method, developed by Livermore scientists, accommodates liquid samples and bypasses the graphitization process, enabling sample preparation and analysis in minutes.
LLNL, UC Davis Partner to Personalize Cancer Medications
With a $7.8 million, five-year grant from the NIH researchers are utilizing accelerator mass spectrometry for cancer research.
Novel Solutions to Fight the Obesity Gene
Potent inhibitors a potential new class of anti-obesity drugs that target one of the most common genetic causes of obesity.
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