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Wednesday, July 30, 2014
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A Triple Ionization Source for LC/MS
Kaveh Jorabchi, Karl Hanold and Jack Syage

This poster reports the development of a triple ionization source consisting of ESI, APCI and APPI sources. The source uses two probes, one for ESI and a nebulizer/vaporizer for APCI and APPI.

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Dual Dopant Approach for Simultaneous LC-APPI-MS/MS Analysis of Low and High Proton Affinity Pesticides
Sheng-Suan (Victor) Cai, Kaveh Jorabchi and Jack Syage

The objectives of the work detailed in this poster was to explore dual dopant approach to maximizing APPI sensitivity for simultaneous analysis of low and high proton affinity compounds.

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Reversed-Phase Point-of-use Purifier for the Removal of Trace Organics in High Purity Water
Coralie Monferran, Cecilia Devaux, Maricar Tarun, Estelle Riche and Daniel Darbouret

Recent developments of Liquid Chromatography instrumentation, such as UHPLC coupled with mass spectrometry, have increased the separation efficiency and sensitivity. Unfortunately, there are some unwelcome consequences. One of these is the detection of trace contamination in the solvents used to prepare mobile phases. The aim of this work was to design a cartridge which produces high water quality for very sensitive LC-MS applications.

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Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Mirko Glinski, Norbert Ganz, Jasper Dingemanse, Laurent Nicolas and Werner Döbelin

Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.

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Hyphenated Techniques as Modern Detection Systems in Ion Chromatography
K.M. Ruth, A. Wille, S. Czyborra and J. Kleimann

Historically ion chromatography (IC) using conductivity detection has been successfully used for the analysis of ionic (e.g., anions and cations) and polar substances (e.g., organic acids or sugars). However, due to current toxicity concerns, analyses in complex matrices require improved sensitivities and selectivities.

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Sequence-Specific Ni(II)-Dependent Peptide Bond Hydrolysis for Protein Engineering. Combinatorial Library Determination of Optimal Sequences

The sequence-specific cleavage of the peptide bond is a crucial procedure in protein engineering and purification. The extreme stability of this bond, with half-life for spontaneous hydrolysis estimated as 350-600 years at neutral pH and room temperature, limits the range of appropriate cleavage reagents.

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An improved data processing pipe-line for comprehensive H-NMR and X/MS -omics data
R. J. O. Torgrip, K. M. Åberg, E. Alm

In the post acqusition analysis of comprehensive -omics data the pre-processing pipe-line is crucial to extract the maximum possible amount of information from the data. Here we show a processing pipe-line for (1D)H-NMR and (2D)X/MS data comprising; feature detection, inter-sample feature alignment and internal-standard free normalization that outperforms today’s state-of-the-art processing schemes.

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LC-MS Approaches to Profiling of Non-Radiolabelled Metabolites in Response to Recent Regulatory Changes
Richard Clayton, Caroline Anderson, Brian Morrison and Lindsay Corfield

Following publication of the FDA MIST guidelines and revision of ICH M3, there is increasing interest in obtaining metabolic profiling data at an early stage in the development of a drug. This has led to a requirement to estimate the relative abundance of metabolites in samples prior to the synthesis of the radiolabelled compound and from a wider range of studies.

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Basic amino acids profiling during hepatic tumorigenesis by hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS)
O. D’Apolito (1), D. Garofalo (1), D. Paris (2), D. Melck (2), R. Calemma (3), F. Izzo (3), G. Palmieri (2), A. Motta (2) and G. Corso (1)

This study is aimed to characterize basic aminoacids profiles from liver tissues of primary hepatocarcinoma (HCC) and metastases from colorectalcarcinomas (MET), and from adjacent cirrhotic related hepatitis-C-virus (CIRR) and non-cirrhotic normal liver (NT). Arginine levels in MET are significantly higher (P<0.05) compared to NT, CIRR and HCC. Although our preliminary data should be validated, profiling of basic aminoacids could allow a better classification of liver malignancies in humans.

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Showing Results 31 - 40 of 84
Scientific News
Mass Spec-Based Metabolomics Workflows to Evaluate Plant Immunity
This article reviews metabolomics studies used to evaluate plant immunity with an emphasis on mass spectrometry in its many forms.
Using LC-MS to Analyse Sulfonamides in Food Grade Honey
Sulfonamides are one of a number of groups of chemicals whose presence in honey is limited by international regulations.
Reimagining UHPLC
To learn more about the new Vanquish UHPLC system from Thermo Fisher Scientific we spoke to Wulff Niedner, Director of HPLC Product Marketing.
Mass Spec Predicts Improved Response to Anti-HER2 Therapy in Breast Cancer
Immunohistochemistry is the standard technique for detecting HER2 protein expression, it does not provide absolute quantification of this receptor and is prone to false-positives.
Mass Spectrometry Tool Helps Guide Brain Cancer Surgery
A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.
Evaluating Acute Hydrogen Sulfide Poisoning in Rats through Serum Metabolomics
Through the use of GC/MS-based metabolomics, researchers have evaluated the effect of acute hydrogen sulfide poisoning on the metabolic profiles of rats.
Simultaneous Determination of Free Urinary Steroids
Researchers have described an LC–MS/MS method that accurate, precise and is in accordance with FDA guidelines.
Human Proteome Project Uncovers 193 Proteins Not Known to Exist
The team of international researchers reports the identification of 193 novel proteins that came from regions of the genome not predicted to code for proteins.
Comparison of Pesticide Residues in Surface and Ground Water
Measurement of pesticide residues can be used as baseline levels to monitor the future changes and to predict their future impact on the population of the area.
New Innovation in Food Safety Testing
Researchers have used MALDI-TOF MS as a tool to detect Listeria contamination in food.
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