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Searching for Urinary Biomarkers of Exposure to Heterocyclic Amines (HCAs)
Rosa Busquets, Henrik L. Frandsen, Kerstin Skog

Heterocyclic amines (HCAs) are foodborne carcinogens present in cooked meat and fish, mainly. Metabolites of HCAs have been determined in urine from volunteers following a controlled meal.

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Metabolic Stability Assay Using Human Hepatocyte Co-cultures and Integrated Qualitative/Quantitative High Resolution Mass Spectrometry
Alex Zang, Ragu Ramanathan, Cornelia Smith, Caroline Lee, Helen Shen, and Zamas Lam

Purpose: To investigate Sequential Window Acquisition of all Theoretical fragment ion spectra (SWATH™) based integrated qualitative and quantitative (qual/quant) assay for simultaneous metabolic stability and metabolite profiling assessments.

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In Vitro Species Comparison Using Long-Term Hepatocyte Co-Cultures Model and Highly Sensitive UHPLC-QTOF-MS with SWATH Analysis
Jian Yu; Ragu Ramanathan; Cornelia Smith; Caroline Lee; Helen Shen; Zamas Lam

Purpose: To develop a reliable, quicker, and cost-saving in vitro method to accurately predict major human metabolite profile in vivo and to de-risk disproportional or unique human metabolites before a drug candidate nomination

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Metabolite Profiling Using Human Hepatocyte Co-cultures and UHPLC-QTOF-MS with Data Independent MS/MS
Ronghua Wang, Ragu Ramanathan, Cornelia Smith, Caroline Lee, Helen Shen, and Zamas Lam

Purpose
To investigate a high throughput workflow for metabolite profiling using a novel human in vitro system and advanced UHPLC-MS/MS techniques to accurately predict human metabolite profile in vivo.

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Mixtures Analysis of Complex Mixtures
Michael Bernstein; Carlos Cobas; Santi Domínguez; Manuel Pérez; Agustín Barba

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.

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A Complete Wine Analysis Using Multiplets Detection
Dr Michael Bernstein1; Agustín Barba1; Dr Susanne Klein2; Dr Andrea Dreiseitel2; Daniel Heidger2 and Volker Heidger2

NMR mixtures analysis can be used to determine the concentration of key components in wine. Here we show the analysis using SMA from Mestrelab.

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DPPH scavenging activities of selected flavonoids and their mixtures
Brachos D.(1)

The aim is to identify the ati-oxidant activity of selected flavonoids (quercetin, luteolin and galangin) and their mixtures using DPPH method including their synergistic or antagonistic interactions.

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Correlation between plasma levels of lutein and oxidized low density lipoproteins: a short human intervention study
Tiziana Bacchetti, Gianna Ferretti

The increase of plasma carotenoids, in particular lutein, after dietary treatment for two weeks is associated with a significant protective effect against lipid peroxidation of plasma lipoproteins.

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Analysis of 10 systemic pesticide residues in various baby foods using liquid chromatography-tandem mass spectrometry
Jae-Han Shim, Angel Yang, A. M. Abd El-Aty, Jong-Hyouk Park, Ayman Goudah, Md. Musfiqur Rahman, Jung-Ah Do

The method developed was sensitive and selective, and detected the analytes below the MRL established by the European Commission and the Korea Food and Drug Administration. The combination of QuEChERS sample preparation and LC-MS/MS analysis provided acceptable quantitative and qualitative results in baby food.

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Showing Results 31 - 40 of 145
Scientific News
Creating Bacterial ‘Fight Clubs’ to Discover New Drugs
Creating bacterial “fight clubs” is an effective way to find new drugs from natural sources.
Iron: A Biological Element?
Study shows findings which have meaning for fields as diverse as mining and the search for life in space.
New Tool on Horizon for Surgeons Treating Cancer Patients
Surgeons could know while their patients are still on the operating table if a tissue is cancerous, according to researchers.
The Perfect Partnership: Research & Industry; Software & Instrumentation. It really starts to come together at ASMS 2015
Collaboration and knowledge-sharing were evident everywhere: on the bus, in the hallways and in the bars. This article aims to capture this theme and share with you some of the fruits of this coming together of science and industry.
Weighing a Virus
Chemists, led by Mark Bier, have separated and weighed virus particles using mass spectrometry.
3D for Top-Down Proteomics: Extra Dimension for More Proteins
Researchers from the University of Wisconsin- Madison have tested the possible applications of adding a "third dimension" to chromatography.
Scientists Come Up with New Technique to Detect Alien Life on Mars
Researchers have provided evidence that combining chromatography/mass spectroscopy with Raman spectroscopy could improve astrobiological studies.
New Test Detects Drug Use From A Single Fingerprint
Research published in the journal Analyst has demonstrated a new, non-invasive test that can detect cocaine use through a simple fingerprint.
Map Diagnostics Developing Mass Spec Test for Down Syndrome
The company hopes that this new test will provide an accessible, affordable and rapid alternative to current screening methods.
LECO Announces Special Events at ASMS
Company to host a series of events during the conference held at the America’s Center, Saint Louis, MO on May 31-June 4.
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