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Detection of Protein-Protein Interactions of the Corepressor Alien
Robert Kob, Niko Escher, Juliane Kelm, Aria Baniahmad, Ferdinand von Eggeling and Christian Melle

The correpressor Alien is shown to interact with several proteins involved in regulation of transcription, DNA repair and cell cycle. Furthermore we found E2F1 transcription to be downregulated by Alien overexpression.

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Whole Body Endogenous Nitric Oxide Production in Patients with Decompensated Liver Disease
Demoncheaux E., Elphick D.A., Dürner M.B., Higgins G.E., Crowther D., Williams E.J., Higenbottam T.W and Gleeson D

Increased nitric oxide (NO) production has been implicated in the pathogenesis of the hyperdynamic circulation found in patients with advanced liver disease. There were no differences between patients with liver disease and controls with regard whole body NO production. Our results, in a well characterised set of patients, argue against greater basal NOS-dependent whole body NO production in patients with decompensated liver disease.

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MS-Xelerator™: Advanced Algorithms for LC/MS Data Processing Applied to Biomarker Discovery, Differential Analysis and Quantitative Proteomics
M.M.A. Ruijken

LC-MS based proteomic experiments are used to compare complex biological samples across multiple conditions. Fast, powerful computational tools are needed to explore and detect differences in the areas of Expression Proteomics and Biomarker Discovery. In general, specialized steps are necessary to solve these difficult problems (binning, alignment & normalization, peak picking, relative quantitation, etc.). MS-Xelerator is a collection of software tools dedicated to all of the above tasks.

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Caveolin-1 Expression as a Possible Biomarker in Pancreatic Cancer Diagnosis
C. Tanase, E. Raducan, L. Albulescu, E. Codorean, M.I. Nicolescu, D.I. Popescu, M.L. Cruceru and A.C. Popa

Caveolin1 (Cav-1) function either as a tumor supressor or as a promoter of metastasis. Overexpresion of cav-1 was correlated with: tumoral grading, proliferration markers (Ki67, p53), serum tumor markers (CEA, CA19.9) and angiogenic markers (VEGF, bFGF).

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Challenges and Considerations for Building an Automated Method Development System
Margaret Antler, Michael McBrien, Andrey Vazhentsev and Vadim Tashlitsky

Automated chromatographic method development systems have been offered for a number of years, with varying degrees of effectiveness. A new system for automated method development, ACD/AutoChrom, is currently under development, and addresses some of the weaknesses of earlier configurations. AutoChrom uses both UV-Visible and MS detection to unequivocally track and resolve trace components, performing a chemometric evaluation of these detection techniques.

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Uranium Oxide Particulate Surrounding a Former Processing Facility
Nicholas S. Lloyd, Randall R. Parrish, Tim S. Brewer, Simon R. Chenery, Sarah V. Hainsworth

This research project aims to improve understanding of the behaviour of DU particulate in the environment, using a case study of a site that is heavily contaminated by past emissions. The research will help predict the long-term fate of pollution from uranium oxide particulate.

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A Sensitive Fluorimetric Assay for Detection of ß-Secretase Activity Using a Novel FRET Peptide Substrate
Xudong Zhu, Xing Han, Manpreet Mann, Rich Meyer, Xiaohe Tong, Anita Hong and Vera Rakhmanova

In order to facilitate high throughput screening of AD drug candidates, we have developed a new SensoLyte™ 520 b-secretase assay kit using a fluorescence resonance energy transfer (FRET) peptide, HiLyte Fluor™ 488-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(QXL™ 520)-OH. The longer excitation and emission wavelengths of HiLyte Fluor™488 minimize the interference from autofluorescence and absorbance of test compounds.

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Glycoprotein Labeling and Detection: Novel Click Chemistry-based Applications for gel Electrophoresis, Flow Cytometry and Fluorescence Microscopy
Brian Agnew, Nancy Ahnert, Suzanne Buck, Scott Clarke, Courtenay Hart, Kapil Kumar, and Tamara Nyberg

We demonstrate highly-selective and sensitive labeling methods for the detection of specific glycoprotein subclasses, including cell surface N- and O-linked glycoproteins and intracellular O-GlcNAc modified proteins, utilizing the copper-catalyzed cycloaddition reaction between azides and alkynes, or click chemistry.

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PRIMe: Platform for RIKEN Metabolomics
Atsushi Fukushima, Miyako Kusano, Kenji Akiyama, Takeshi Obayashi, Takayuki Tohge, Masami Yokota Hirai, Shigehiko Kanaya, Masanori Arita, Yoko Shinbo, Kazuo Shinozaki, Tetsuya Sakurai and Kazuki Saito

We have developed a web-based database, "PRIMe (Platform for RIKEN Metabolomics)," which contains powerful tools for researchers to analyze gene co-expression data and mass spectral data. PRIMe has been developed with the main aim of facilitating integrated analysis for transcriptomics and metabolomics.

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Showing Results 81 - 90 of 105
Scientific News
Charge-Tagged Proline-Based Organocatalyst for Mechanistic Studies Using ESI-MS
In a comparative continous flow ESI-MS study, researchers use a new charged catalyst and neutral L-proline to investigate the proline-catalyzed inverse crossed aldol reaction of aldehydes with diethyl ketomalonate.
Mass Spec Sample Prep Cut From Days to Minutes
The method, developed by Livermore scientists, accommodates liquid samples and bypasses the graphitization process, enabling sample preparation and analysis in minutes.
LLNL, UC Davis Partner to Personalize Cancer Medications
With a $7.8 million, five-year grant from the NIH researchers are utilizing accelerator mass spectrometry for cancer research.
Novel Solutions to Fight the Obesity Gene
Potent inhibitors a potential new class of anti-obesity drugs that target one of the most common genetic causes of obesity.
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
Detecting Pharmaceutical and Personal Care Products in Water
A simple, more convenient method than conventional guidelines.
Mass Spectrometry in Your Hand
Electrospray arrays can dramatically downsize systems and costs for onsite chemical analysis and many other applications.
Study Aims to Develop Breath Test for COPD
A new clinical iniative, lead by NYU Langone Medical Center, aims to determine a breath test’s effectiveness to identify volatile organic compounds (VOCs) in human breath that are biomarkers of chronic obstructive pulmonary disease (COPD).
Comparison of Caffeinated and Decaffeinated Coffee - Implications for Alzheimer's Disease
Researchers from the National University of Singapore successfully demonstrated the viability of GC-TOF-MS as an analytical platform for metabolomics analysis of coffee samples.
Repressing the Repressors May Drive Tissue-Specific Cancers
Stowers scientists establish Drosophila and mammalian models to study mutations found in pediatric brain tumors.
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