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CESI 8000 High Performance Separation-Electrospray Ionization System for Mass Spectrometry

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The new CESI 8000 System for Biologics Characterization is an innovative, high-performance separation-electrospray ionization system for mass spectrometry (MS).  The CESI 8000 utilizes a new front-end separation and ionization technology called CESI, which combines the high efficiency and ultra-low flow of capillary electrophoresis (CE) with an integrated electrospray ionization source. This optimization of electrospray ionization (ESI) into the nanoflow region greatly improves assay sensitivity and reduces ion suppression.

The CESI 8000 can be integrated with the AB Sciex TripleTOF® 5600+ and Thermo Scientific Orbitrap mass spectrometry systems into a seamless solution, to give biopharmaceutical scientists the ability to advance therapeutics discovery, research and development through the life cycle of the product. 

With a single approach that increases efficiency and productivity, the CESI 8000 system provides orthogonal and/or superior results compared to dual-method liquid chromatography / mass spectrometry-based approaches.

From a single enzyme digest and run, users of CESI-MS gain the following:

  • Biologics primary sequence heterogeneity determination through extensive glycopeptide coverage and quantitation
  • Stability indicating degradative hotspot information like aspargine- deamidation, methionine-oxidation, and glutamic-acid-cyclization
  • Identification and purity by full peptide mapping coverage
  • No sample carryover
  • Increased throughput
Product CESI 8000 High Performance Separation-Electrospray Ionization System for Mass Spectrometry
Company Sciex
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500 Old Connecticut Path Framingham MA 01701 USA

Tel: 1-877-740-2129
Fax: 1-800-343-1346

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