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Worried about your cell-based assays?  R...
World of Technology & Science 2014...Catalysis in Flow: Operando Study of Pd ...Evolutionary perspectives on automated s...

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Webcasts
Identification of Atg-8–Atg 3 protein-protein interaction inhibitor
Jürgen Bosch, Johns Hopkins University, speaking at Drug Discovery and Development 2014
Rising Role of Academic Drug Discovery
Barbara Slusher, Johns Hopkins University School of Medicine, speaking at Drug Discovery and Development 2014.

Market Reports
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Flow Chemistry Market by Reactor Type, Application & Geography - Trends & Forecast to 2018
MarketsandMarkets

This report Flow Chemistry Market is segmented by type of reactor with major focus on micro reactor systems. The micro reactor system market is further segmented by type along with geography and applications.
Bionanotechnology
RI Technologies

This report on Bionanotechnology studies the impact of nanotechnology in various biotechnology applications. The study focuses on major applications including food, drug discovery and development, diagnostic tools and devices, and other (bionanosensors).
Chiral Chemicals
RI Technologies

This report focuses on the different methods and applications of Chiral Chemicals and their impact. The study provides global market analysis for preparation of chiral chemicals by traditional, asymmetric and biological methodologies.
China Pharmaceutical Market Outlook
Global Data

The report details the macroeconomic environment of China, providing a background of the financial and demographic situations in the country, as well as identifying key demographics. It covers the pharmaceutical market broken down by market segment, and the popularity of biosimilars and biologics, identifying where the strongest market potentials lie.
Pathways to Efficient Drug Development - Advances in Modeling and Simulation Outcomes to Fuel Pipeline Productivity
GBI Research

The report examines the reasons why the pharmaceutical industry is looking for improvements in efficiency whilst acknowledging that pharmaceutical R&D remains a long and risky process. It looks in detail at precompetitive research and evaluates how the industry is pulling together to research solutions to problems that are common to all companies.
Drug Discovery and Development Market in Asia
Global Data

The report provides key data, information and analysis of the major trends and issues affecting the drug discovery and development market in seven major countries in Asia, namely China, India, Russia, Japan, Singapore, Taiwan and South Korea.
Phenotypic Drug Discovery Trends 2013
HTStec

HTStec's Phenotypic Drug Discovery Trends 2013 report was published on 20 March 2013. This 59 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on phenotypic drug discovery (PDD) carried out in March 2013.
Benchtop Automation Trends 2013
HTStec

This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Scientific News
Computer Model Sets New Precedent in Drug Discovery
New computational model can precisely simulate, predict therapeutic protein behaviors to help zero in on ideal drug design candidates.
New Drug for Common Liver Disease Improves Liver Health
An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the NIH.
'Rewriting' the Way to Make Natural Drug Compounds
Using an organism's own pathway to synthesize potential therapeutics.
MS Drug Candidate Shows Promise for Ulcerative Colitis
Positive new clinical data were released today on a drug candidate for ulcerative colitis that was first discovered and synthesized at The Scripps Research Institute.
New Technique has Profound Implications for Drug Development
The method, developed by Scripps Research Institute chemists, expands options for making pure batches of ‘one-handed’ molecules.
Team Discovers How Microbes Build a Powerful Antibiotic
Researchers discovery opens up new avenues of research into thousands of similar molecules.
Misfolded Proteins Clump Together in a Surprising Place
Stowers researchers create new framework for protein aggregation under acute stress.
Nanoparticle Research Could Enhance Drug Delivery Through Skin
A milestone study from the University of Southampton could have major implications for the delivery of drugs.
Chemists Recruit Anthrax to Deliver Cancer Drugs
With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
Business News
Actavis to Acquire Allergan for $66 Billion
Transaction has been unanimously approved by the Boards of Directors of Actavis and Allergan, and is supported by the management teams of both companies.
Charities Pledge to Inject Millions to Jump Start Drug Development for Brain Diseases
MRC Technology to lead Neurodegeneration Medicines Acceleration Programme to uncover promising drugs in pharma libraries.
FDA Approval for Lilly's Gastric Cancer Drug
CYRAMZA now approved both as a single-agent treatment and in combination with chemotherapy.
Clanotech Receives Orphan Drug Designation in the EU
Company’s drug CLT-28643 receives drug designation for prevention of scarring post glaucoma filtration surgery.
Labcorp To Acquire Covance For Approximately $5.6 Billion
Combination creates comprehensive healthcare diagnostics company offering customers end-to-end solutions for drug and diagnostics development and commercialization.
Charles River Acquires ChanTest
Addition broadens Charles Rivers' existing discovery-focused ion channel capabilities.
Auspherix, Domainex to Develop Drugs to Treat Antibiotic-Resistant Bacterial Infection
Collaboration will progress Auspherix’s novel anti-infective drug discovery programme towards the nomination of a clinical candidate.
AB SCIEX Wins New Product Innovation Award in Asia Pacific
The award recognizes the company’s continued innovation in the mass spectrometry industry and a number of new products introduced into the market in recent years.
Calixar, Aston University Announce Multidrug Resistance Collaboration
Purpose is to study the extraction, stabilization and crystallization of full-length human ABC transporters involved in multidrug resistance.
Agilent to Close NMR Business
The announcement is part of Agilent's strategy to address the business shortfalls of its Research Products Division.

Events
Pharmacovigilance, Drug Safety
26 Nov 2014
Pharmacovigilance, Drug Safety ...
Anti-counterfeiting and anti-d
02 Dec 2014
Anti-counterfeiting and anti-d ...
Cold Chain Distribution
02 Dec 2014
Cold Chain Distribution ...
Central Labs Partnerships Foru
11 Dec 2014
Central Labs Partnerships Foru ...

ePosters
Relationships between Water Quality Constituents in the Delta and the Influence of Different Sources of Water
Richard Denton & Associates, Metropolitan Water District of Southern California

Analysis of detailed grab sample data from San Francisco Bay and Delta and development of regression relationships between EC, TDS and water quality constituents such as chloride, bromide, sodium, calcium, sulfate, alkalinity and hardness. The relationships in the interior Delta vary depending upon the percentage contributions from seawater, agricultural drainage and freshwater inflows.
Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
Novel Approaches to High-throughput Measurements of Replicative Lifespan in Yeast by Microfluidic Size Sorting and Genetic Engineering
HTW Berlin, Dept. Life Science Engineering, Berlin, Germany

Development of a high-throughput screen utilizing a microfluidic device and a linearly growing yeast strain to simultaneously test the influence of various drugs on the replicative lifespan of yeast.
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
MRCT

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.
The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Axxam

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.
Enabling Epigenetics Studies from HTS to SAR : A Novel HTRF® Platform to Identify and Characterize Reader Domain Inhibitors
1Cisbio Bioassays Codolet, France | 2CRCM, CNRS UMR7258, INSERM U1068, AMU UM105, Institut Paoli-Calmettes, Marseille, France | 3AFMB, UMR7257, Univ. Aix Marseille-CNR

Discover a novel HTRF platform to identify and characterize the vast variety of epigenetic binding domain.

Automated Fluorescence Detection and Imaging of RNA Species in Live Cells
1BioTek Instruments, Inc., Winooski, Vermont • 2EMD Millipore Temecula, California

This poster describes the detection and quantification of RNA species in Live cells through automated imaging.
Validation of a 3-Dimensional Human Liver Microtissue Model for Long-term Hepatotoxicity Studies
1BioTek Instruments, 2InSphero, Inc. 3Bioreclamation I VT, 4 Promega Corporation

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drug commonly used as analgesics and antipyretics, as well as for management of rheumatological disorders. They are one of the most highly prescribed drug families around the world, and consequently, along with antimicrobial agents, are the most frequent causes of druginduced liver injury (DILI) (Bjornsson et al., 2010).
Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Department of Chemistry, Virginia Tech,Virginia Tech Carilion Research Institute

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
1Space Research Centre, University of Leicester, Leicester, LE1 7RH, UK. 2Clinical Imaging Group, Sandwell and West Birmingham Hospital NHS Trust, West Bromwich B71 4HJ, UK.
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
Application Notes
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Cytotoxicity in Cells: Easy Determination Using Lonza ViaLight Plus and ToxiLight BioAssays on the SpectraMax L Microplate Luminometer
Molecular Devices

Bioluminescent cytotoxicity assays offer the user increased detection limits, speed, and accuracy, and have been well documented (Crouch et al., 1993). Healthy cells maintain a high constant ATP concentration in culture. During proliferation, the total ATP in the culture increases in line with cell number. Conversely, dying cells are unable to maintain their high ATP level, as synthesis becomes compromised, and so levels are seen to reduce. The level of ATP present within a culture is indicative
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
Analysing Endotherms using Atlas
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at endothermic processes.
Tracking Exotherms using Atlas Reaction Monitoring
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at exothermic processes.
Reaction Monitoring with Atlas 1
Syrris Ltd

This application note reports the use of the atlas system to monitor the hydrolysis of acetic anhydride, a typical test reaction for exothermic processes.
Reaction Monitoring with Atlas 2
Syrris Ltd

This application note details an experiment to show the repeatability and scalability of reaction monitoring signals by using an electrical heater system.
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