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Webcasts
Kinases as Targets for Drug Discovery in an Academic Setting
William Janzen,The University of North Carolina at Chapel Hill, speaking at Drug Discovery and Development 2014
What Can We Learn from Fragment Based Optimization Programs?
Gyorgy Keseru, Hungarian Academy of Sciences, speaking at Drug Discovery and Development 2014

Market Reports
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Flow Chemistry Market by Reactor Type, Application & Geography - Trends & Forecast to 2018
MarketsandMarkets

This report Flow Chemistry Market is segmented by type of reactor with major focus on micro reactor systems. The micro reactor system market is further segmented by type along with geography and applications.
Bionanotechnology
RI Technologies

This report on Bionanotechnology studies the impact of nanotechnology in various biotechnology applications. The study focuses on major applications including food, drug discovery and development, diagnostic tools and devices, and other (bionanosensors).
Chiral Chemicals
RI Technologies

This report focuses on the different methods and applications of Chiral Chemicals and their impact. The study provides global market analysis for preparation of chiral chemicals by traditional, asymmetric and biological methodologies.
China Pharmaceutical Market Outlook
Global Data

The report details the macroeconomic environment of China, providing a background of the financial and demographic situations in the country, as well as identifying key demographics. It covers the pharmaceutical market broken down by market segment, and the popularity of biosimilars and biologics, identifying where the strongest market potentials lie.
Pathways to Efficient Drug Development - Advances in Modeling and Simulation Outcomes to Fuel Pipeline Productivity
GBI Research

The report examines the reasons why the pharmaceutical industry is looking for improvements in efficiency whilst acknowledging that pharmaceutical R&D remains a long and risky process. It looks in detail at precompetitive research and evaluates how the industry is pulling together to research solutions to problems that are common to all companies.
Drug Discovery and Development Market in Asia
Global Data

The report provides key data, information and analysis of the major trends and issues affecting the drug discovery and development market in seven major countries in Asia, namely China, India, Russia, Japan, Singapore, Taiwan and South Korea.
Phenotypic Drug Discovery Trends 2013
HTStec

HTStec's Phenotypic Drug Discovery Trends 2013 report was published on 20 March 2013. This 59 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on phenotypic drug discovery (PDD) carried out in March 2013.
Benchtop Automation Trends 2013
HTStec

This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Scientific News
Novogen Announces Important Discovery in Regenerative Medicine Program
A key proof-of-concept step to develop drugs capable of stimulating the function of brain tissue stem cells.
Stanford Chemists Take Step Toward Solving Mystery of How Enzymes Work
Steven Boxer and his students have found that the electrostatic field within an enzyme accounts for the lion's share of its success.
New Class of Synthetic Molecules Mimics Antibodies
A Yale University lab has crafted the first synthetic molecules that have both the targeting and response functions of antibodies.
The Hunt for Botanicals
Herbal medicine can be a double-edged sword and should be more rigorously investigated for both its beneficial and harmful effects, say researchers writing in a special supplement of Science.
Novel Agent Decreases Neuropathic Pain in Patients with Type 2 Diabetes
Promising profile of disease modification and pain reduction leads to proof of concept trials.
Barrier-Breaking Drug May Lead to Spinal Cord Injury Treatments
NIH-funded scientists take first step towards developing promising new drug.
Two Drugs are No More Effective Than One to Treat Common Kidney Disease
NIH study finds limited kidney benefit from more rigorous blood pressure treatment.
Antibiotic Resistance Threatens Future of Modern Medicine
Overuse and misuse of antibiotics, one of the key contributors to antimicrobial resistance (AMR).
Computer Model Sets New Precedent in Drug Discovery
New computational model can precisely simulate, predict therapeutic protein behaviors to help zero in on ideal drug design candidates.
New Drug for Common Liver Disease Improves Liver Health
An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the NIH.
Business News
Sygnature Discovery Strengthens Team with Three Key Appointments
Company appoints Dr Tim Schulz-Utermoehl, Dr Martin Quibell and Dr Scott Pollack.
Director of External Projects Appointed at Xenogesis
Nottingham-based Clinical Research Organization appoints Graham Trevitt PhD as Director.
New Vice-chair Appointed to Commission on Human Medicines
Dr Angela Thomas replaces Professor Ian Weller who retired from the position and from CHM on 31 December 2014.
UCB Announces US and EU Regulatory Filings for Brivaracetam
Major milestone for brivaracetam is latest step towards UCB goal of extending treatment choices for adult epilepsy patients with uncontrolled partial-onset seizures.
Aprea Granted European Orphan Drug Designation for APR-246 in Ovarian Cancer
Company is currently conducting a Phase Ib/II trial of APR-246.
Dilaforette Receives Positive COMP Opinion
Positive opinion on orphan drug designation in the EU for sevuparin in sickle-cell disease.
AMRI Receives NIH Contract Award
10-year federal contract award valued at up to $37 million.
ThromboGenics Appoints Dominique Vanfleteren as New CFO
Dominique has over 25 years of experience in senior finance, operational, control and reporting roles.
BEYOND RESEARCH Initiative of 4SC Discovery and CRELUX Reaches First Milestone
Compounds for inhibiting oxygen radicals and associated signalling pathways optimized for developing innovative therapies for degenerative diseases.
Evotec and Padlock Therapeutics Extend Collaboration
Evotec and Padlock Therapeutics announce initial success and extension of long-term collaboration.

Events
GDP Workshops
11 Feb 2015
GDP Workshops ...
Government Drug Pricing Forum
12 Feb 2015
Government Drug Pricing Forum ...
Advances and Progress in Drug
16 Feb 2015
Advances and Progress in Drug ...
Screening Europe
17 Feb 2015
Screening Europe ...

ePosters
Automated detection and control of controlled substances
Scitegrity Limited

Scitegrity, in conjunction with the Pistoia Alliance and a number of pharmaceutical companies, have developed Controlled Substances Squared to scan large chemical libraries (millions of compounds) and determine whether a compound is considered as controlled in a selected country.
Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
Bauer4.1TATAA Biocenter, Göteborg, Sweden (www.tataa.com); 2Inst. of Biotechnology, CAS, Czech Republic; 3AdnaGen GmbH, Ostpassage7, D-30853 Langenhagen, Germany (www.adnagen.com); 4Dep of Gynecoland

We show non-responders to treatment among breast cancer patients can be identified by expression profiling of circulating tumor cells
Antioxidant and Free Radicals Scavenging Activity of Biomolecules: Hydroxamic Acids
School of Study in Chemistry, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

In the present poster attention is focused towards the investigation of antioxidant and free radicals scavenging activity of N-aryl substituted hydroxamic acids by DPPH method which is based on the reduction of alcoholic DPPH solutions in presence of a hydrogen donating antioxidant, hydroxamic acids.
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Relationships between Water Quality Constituents in the Delta and the Influence of Different Sources of Water
Richard Denton & Associates, Metropolitan Water District of Southern California

Analysis of detailed grab sample data from San Francisco Bay and Delta and development of regression relationships between EC, TDS and water quality constituents such as chloride, bromide, sodium, calcium, sulfate, alkalinity and hardness. The relationships in the interior Delta vary depending upon the percentage contributions from seawater, agricultural drainage and freshwater inflows.
Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
Novel Approaches to High-throughput Measurements of Replicative Lifespan in Yeast by Microfluidic Size Sorting and Genetic Engineering
HTW Berlin, Dept. Life Science Engineering, Berlin, Germany

Development of a high-throughput screen utilizing a microfluidic device and a linearly growing yeast strain to simultaneously test the influence of various drugs on the replicative lifespan of yeast.
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
MRCT

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.
The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Axxam

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.
Enabling Epigenetics Studies from HTS to SAR : A Novel HTRF® Platform to Identify and Characterize Reader Domain Inhibitors
1Cisbio Bioassays Codolet, France | 2CRCM, CNRS UMR7258, INSERM U1068, AMU UM105, Institut Paoli-Calmettes, Marseille, France | 3AFMB, UMR7257, Univ. Aix Marseille-CNR

Discover a novel HTRF platform to identify and characterize the vast variety of epigenetic binding domain.

Application Notes
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Cytotoxicity in Cells: Easy Determination Using Lonza ViaLight Plus and ToxiLight BioAssays on the SpectraMax L Microplate Luminometer
Molecular Devices

Bioluminescent cytotoxicity assays offer the user increased detection limits, speed, and accuracy, and have been well documented (Crouch et al., 1993). Healthy cells maintain a high constant ATP concentration in culture. During proliferation, the total ATP in the culture increases in line with cell number. Conversely, dying cells are unable to maintain their high ATP level, as synthesis becomes compromised, and so levels are seen to reduce. The level of ATP present within a culture is indicative
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
Analysing Endotherms using Atlas
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at endothermic processes.
Tracking Exotherms using Atlas Reaction Monitoring
Syrris Ltd

This application note shows how atlas and reaction monitoring can be used to look at exothermic processes.
Reaction Monitoring with Atlas 1
Syrris Ltd

This application note reports the use of the atlas system to monitor the hydrolysis of acetic anhydride, a typical test reaction for exothermic processes.
Reaction Monitoring with Atlas 2
Syrris Ltd

This application note details an experiment to show the repeatability and scalability of reaction monitoring signals by using an electrical heater system.
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