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  Events - November 2012


Introduction to Photostability

23 Nov 2012 - 23 Nov 2012 - Islington, London,



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Course objectives
All PharmaTraining courses focus on two key objectives. These are to provide attendees with knowledge - information, which will assist you in making better judgements - and skills, which will allow you to apply the knowledge you have received. We guarantee to engage your interest and commitment on the course, and we expect our training to improve your effectiveness.

About this course
The purpose of this course is to give an overview of photostability,and where it fits in the stability testing programme and the importance of photostability. The course is highly interactive and held in a relaxed environment.

It will cover:
. Why do we do photostability tests?
. Concepts and background in photostability
. Identifying drug substances most likely to absorb light and display signs of poor photostability
. Understanding photostability terminology
. Where does phototstability fit in the overall stability testing program?
. Why does photostability matter? (exercise)

Who will benefit: The course is designed for people working in:
. Analytical Development
. Analytical Chemistry
. Stability Testing

Course Programme
Coffee and registration will be available from 8.30am, course proper will commence at 9.00am. We anticipate the course will finish at 5.00pm.

Formulating and manufacturing unstable products
. Formulation development and evaluation for photolabile materials
. Protection during the manufacturing process
. Getting the product to the patient

ICH guidelines for photostability testing: Using ICH Q1B guidance in practice
. understanding the terms and procedures used in the guideline

Practicalities
. Light source selection - Options 1 and 2
. Sample presentation
. Humidity and temperature control
. Selecting sample containers

Forced degradation: Practical and regulatory aspects of photostability
stress testing
. Selecting experimental conditions for stressing samples with respect to light
Meeting regulatory requirements
. Documentation – principles and practice
. Stability testing and the Quality System
. SOPs for stability testing
. Equipment validation and calibration – do the chambers work?
. Protocol development and approval
Reporting stability test data
Delegate Workshop
Problems and issues for discussion

Additional Resources
Online access to comprehensive publications including all relevant guidance will be provided as well as colour copies of all presentations and case studies.
. Technical Operations
. Research and Development Chemistry
. QA/QC
. Formulation Development
. Pharmaceutical & Biopharmaceutical Manufacturing/Production
. Product Development
. Regulatory Affairs
. GLP/GMP Compliance

Speaker:
Dr Michael Gamlen is Managing Director of Pharmaceutical Development Services Ltd, a pharmaceutical consultancy based in Nottingham (UK). Dr Gamlen has over 30 years experience of product stability testing. Awarded a First Class Honours degree in Pharmacy, specialising in Pharmaceutical Engineering, he studied for a PhD at Nottingham University. He was Head of Tablet Development at the The Wellcome Foundation for 15 years, and worked as an outsourcing manager before starting his consultancy business in 2000. Dr Gamlen specialises in managing product development, formulation, tablet and process development studies. He has been teaching professional tabletting courses for many years and his courses are highly rated, exceeding the expectation of the participants in many cases.

Michael continually updates the content of his courses with the latest guidance and extracts of up-to-the minute scientific papers. He provides a substantial body of relevant literature to all course participants as well as copies of all notes and guidance used and a workbook. He is a popular and highly respected presenter.



Further information
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Improving Delivery of Poorly Soluble Drugs Using Nanoparticles
A technology that could forever change the delivery of drugs is undergoing evaluation by the Technology Evaluation Consortium™ (TEC). Developed by researchers at Northeastern University, the technology is capable of creating nanoparticle structures that could deliver drugs into the bloodstream orally – despite the fact that they are normally poorly soluble.
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Startup develops more cost-effective test for assessing how cells respond to chemicals.
New Mechanism of Antitumor Action Identified
A team of UAB researchers and collaborators from the Catalan biotech company Ability Pharmaceuticals (UAB Research Park), have described a new mechanism of anti-tumour action, identified during the study and development of the new drug ABTL0812.
Nanoparticles Deliver Tumor Suppressors to Damaged Livers
UT Southwestern Medical Center chemists have successfully used synthetic nanoparticles to deliver tumor-suppressing therapies to diseased livers with cancer, an important hurdle scientists have been struggling to conquer.
Experimental Combination Surprises with Anti-HIV Effectiveness
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A New Type of Anticancer Agent
Success in the development of a ?-tubulin specific inhibitor.
Nanoparticles Proven Effective Against Antibiotic-Resistant “Superbugs”
In the ever-escalating evolutionary battle with drug-resistant bacteria, humans may soon have a leg up thanks to adaptive, light-activated nanotherapy developed by researchers at the University of Colorado Boulder.
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