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Webcasts
Managing Pharmaceutical Lab Data Management to Ensure Compliance
Join Stacey Brown and William Leonard, Senior Validation Analysts for Informatics at Thermo Fisher Scientific, to understand more about the complex requirements of pharmaceutical data management.
Handling Slower Reactions in Flow
Robert Ashe, AM Technology, speaking at Flow Chemistry India 2015

Market Reports
Emerging Pharmaceutical Markets 2012
Select Biosciences Ltd

The report covers all the key aspects of the various emerging pharmaceutical markets and has broadly outlined the factors that are affecting the industry. The report also provides current and predicted future performance of the pharmaceutical market in different regions of the world.
The Future of GPCRs in Drug Discovery
Business Insights

This report analyzes which classes of GPCR and specific GPCRs have been exploited. It looks at novel approaches to targeting GPCRs and their benefits and explores potential targets that could be of relevance to major, under-treated diseases. The report profiles small companies specializing in specific aspects of GPCR technology and analyzes the commercial outlook drugs targeting GPCRs.
Scientific News
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Future of Medicine Could be Found in a Tiny Crystal Ball
A Drexel University materials scientist has discovered a way to grow a crystal ball in a lab. Not the kind that soothsayers use to predict the future, but a microscopic version that could be used to encapsulate medication in a way that would allow it to deliver its curative payload more effectively inside the body.
Improving Delivery of Poorly Soluble Drugs Using Nanoparticles
A technology that could forever change the delivery of drugs is undergoing evaluation by the Technology Evaluation Consortium™ (TEC). Developed by researchers at Northeastern University, the technology is capable of creating nanoparticle structures that could deliver drugs into the bloodstream orally – despite the fact that they are normally poorly soluble.
Faster Drug Discovery?
Startup develops more cost-effective test for assessing how cells respond to chemicals.
New Mechanism of Antitumor Action Identified
A team of UAB researchers and collaborators from the Catalan biotech company Ability Pharmaceuticals (UAB Research Park), have described a new mechanism of anti-tumour action, identified during the study and development of the new drug ABTL0812.
Nanoparticles Deliver Tumor Suppressors to Damaged Livers
UT Southwestern Medical Center chemists have successfully used synthetic nanoparticles to deliver tumor-suppressing therapies to diseased livers with cancer, an important hurdle scientists have been struggling to conquer.
Experimental Combination Surprises with Anti-HIV Effectiveness
A compound developed to protect the nervous system from HIV surprised researchers by augmenting the effectiveness of an investigational antiretroviral drug beyond anything expected.
A New Type of Anticancer Agent
Success in the development of a ?-tubulin specific inhibitor.
Nanoparticles Proven Effective Against Antibiotic-Resistant “Superbugs”
In the ever-escalating evolutionary battle with drug-resistant bacteria, humans may soon have a leg up thanks to adaptive, light-activated nanotherapy developed by researchers at the University of Colorado Boulder.
Versatile New Molecule-Building Technique
Chemists at The Scripps Research Institute (TSRI) have devised a new and widely applicable technique for building potential drug molecules and other organic compounds.
Business News
Nordic Nanovector Awarded NOK 15M
Nordic Nanovector ASA is pleased to announce the award of a up to NOK 15 million grant from the Research Council of Norway’s User-driven Research-based Innovation programme to support the research and development of novel targeted therapeutics for leukemia and non-Hodgkin Lymphoma.
DTRA Awards $9.7M Contract for Drug Development
The Defense Threat Reduction Agency (DTRA) has awarded Emory University a $9.7M contract to develop drugs to treat infections caused by emerging and man-made viral threats. Under the contract, the DTRA funds will be used to advance the development of the lead drug candidate.
Gene Murano Announced as CASSS Hancock Award Winner for 2016
CASSS has honored Genesio “Gene” Murano, PhD, principal/partner with Bioscope Associates, LLC, with its prestigious Hancock Award for Outstanding Achievements in CMC Regulatory Science.
Trillium Acquires Fluorinov
Trillium Therapeutics Inc. a clinical immuno-oncology company developing innovative therapies for the treatment of cancer, has announced that it has acquired all of the outstanding shares of Fluorinov Pharma Inc., a privately-held oncology company.
ACD/Labs Celebrates 500th Customer in Asia & Pacific Region
ACD/Labs customers provide their unique perspectives on solutions deployed and used over the last decade.
Scientists Indicted For Allegedly Stealing GSK Trade Secrets
An indictment was filed today charging five people in an alleged scheme to steal biopharmaceutical trade secrets from pharmaceutical company GlaxoSmithKline (GSK), announced United States Attorney Zane David Memeger.
LDC, Roche Partner
LDC and Roche will jointly advance innovative drug discovery projects.
BioAscent, Pierre Fabre Collaborate
Pharma and cosmetics multinational selects BioAscent as central hub for storage and logistics of extensive plant natural extracts collection.
Shire to Combine with Baxalta
Combination creates leading global biotechnology company projected to deliver double-digit top-line growth with over $20 billion in annual revenues by 2020.
FDA Awards Breakthrough Therapy Designation to Boehringer’s Lung Cancer Candidate
Boehringer Ingelheim Pharmaceuticals has scored FDA breakthrough therapy designation for its candidate to treat patients with T790M mutation-positive non-small cell lung cancer.

Events
World Generic Medicines Congre
10 Feb 2016
World Generic Medicines Congre ...
Ageing 2016
09 Feb 2016
Ageing 2016 ...
Advances and Progress in Drug
15 Feb 2016
Advances and Progress in Drug ...
Flow Chemistry Europe 2016 - 6
16 Feb 2016
Flow Chemistry Europe 2016 - 6 ...

ePosters
A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster
Promega Corporation

Luciferase-based reporter-gene assays remain a cornerstone of high-throughput screening of compounds because of their high sensitivity and dynamic range. However, a substantial number of non-relevant hits can be generated due to direct interaction of compounds with the luciferase reporter.
CellTiter-Glo® 2.0: A Novel Luminescent Cell Viability Assay with Greatly Enhanced Storage Stability
Promega Corporation

Here we report on the attributes of a novel ATP detection reagent for cell viability with all of the assay performance of the previous CellTiter-Glo® Reagent, but now with markedly enhanced stability as a single component in a liquid format. These new features provide for much greater ease-of-use in that storage of the reagent at 4°C eliminates the requirement for reagent thawing and minimizes temperature equilibration time.
Design and Validation of Bioluminescent Assays for 3D Cell Culture Models Poster
Promega Corporation

Cells cultured in 3D model systems often acquire relatively large in vivo-like structures compared to the thickness of a 2D monolayer of cells grown on standard plastic plates.
iPSC-Derived Cardiomyocytes and Luciferase Reporters: A Robust Reporting Platform for Monitoring Cardioprotection and Pathway Biology in Endogenous Human Tissue Cells
Promega Corporation

Pathophysiological conditions, medical interventions, and off-target toxicities can all result in cellular oxidative stress. In cardiac myocytes, prolonged and/or excessive oxidative stress can lead to cardiotoxicity: a primary cause of developmental delays, black-box warnings, and post-launch withdrawal of pharmaceuticals.
Testing a Novel Real Time Cell Viability Assay
Promega Corporation

Recently developed assay technologies make it possible to use multi-well plate readers to measure the number of live or dead cells in culture in real time over a period of days. Live cells are measured in real time by adding a reagent containing a shrimp-derived luciferase and a pro-substrate directly to the culture medium. Only viable cells can convert the pro-substrate into a luciferase substrate and generate light.
The P450-Glo™ CYP2B6 Assay: a Rapid and Selective Assay for Measuring CYP2B6 Induction and Inhibition
Promega Corporation

We have developed a luminogenic CYP2B6 assay for biochemical CYP2B6 inhibition and for cell-based CYP2B6 induction studies. Here we present the CYP2B6 luminogenic assay characterization and demonstrate its utility for measuring time dependent CYP2B6 inhibition, and for measuring CYP2B6 induction in cultured primary human hepatocytes with normalization to viable cell count.
Predicting Regioselectivityand Labilityof Cytochrome P450 Metabolism using Quantum Mechanical Simulations
Optibrium

Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism using Quantum Mechanical Simulations
An HTS-Compatible Plate For Highly Miniaturized Cultures Of Primary Human Bronchial Epithelial Cells At Air-Liquid Interface
1BellBrook Labs, Madison, WI, USA 2UAB Cystic Fibrosis Research Center, Birmingham, AL, USA

Primary human bronchial epithelial cells (HBE) cultured at air liquid interface (ALI) exhibit striking similarity to the in vivo situation, including both tissue architecture and ion channel functionality. Cultures of this type serve as a gold standard for predicting therapeutic activity in airway diseases such as cystic fibrosis.
The Prestwick Chemical Library (R), A Valuable Tool for Screening
1. Prestwick Chemical, 220 Blvd Gonthier d'Andernach, 67400 Strasbourg-Illkirch, FRANCE 2. University of Strasbourg, Therapeuthic Innovation Laboratory, UMR7200 CNRS, Faculty of Pharmacy, 74 route du

The Prestwick Chemical Library® (PCL) is Prestwick’s flagship product dedicated to screening. It is a collection of 1280 molecules comprising 100% approved drugs (FDA, EMEA and other agencies) selected for their high chemical and pharmacological diversity. The PCL was designed to reduce the risk of "low quality" hits and therefore the cost of the initial screening, and appears to be an efficient smart library for hit discovery. The PCL comes with an extended fully-annotated database.
Building a Diverse and Experimentally-Curated Fragment Library
Key Organics Limited, Cornwall, UK, NMX Research and Solutions, Montreal, Broad Institute, Cambridge, MA, USA CA,

Presenting a new fragment collection with experimentally-determined aqueous solubility that will address a major source of false positives and attrition in fragment screening
Application Notes
The Application of MicroCal VP Capillary DSC at a Contract Development Organization
Malvern Instruments Limited

In this application note we describe a systematic approach to preformulation development that leverages biophysical characterization and standard analytics in the context of statistical design with the goal of shortening the pharmaceutical development cycle while improving the quality of the development studies.
Measuring The Particle Size Of Small Sample Volumes Using Laser Diffraction
Malvern Instruments Limited


Detecting the Presence of Anomolous Large Particles Within Powders Using Laser Diffraction Particle Size Analysis
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.
Measuring Small Quantities of Dry Powder Using the Aero S and Mastersizer 3000
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials with good reproducibility and illustrating the dispersion abilities of the Aero S.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Cytotoxicity in Cells: Easy Determination Using Lonza ViaLight Plus and ToxiLight BioAssays on the SpectraMax L Microplate Luminometer
Molecular Devices

Bioluminescent cytotoxicity assays offer the user increased detection limits, speed, and accuracy, and have been well documented (Crouch et al., 1993). Healthy cells maintain a high constant ATP concentration in culture. During proliferation, the total ATP in the culture increases in line with cell number. Conversely, dying cells are unable to maintain their high ATP level, as synthesis becomes compromised, and so levels are seen to reduce. The level of ATP present within a culture is indicative
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Heating on an Atlas Hotplate
Syrris Ltd

In the following experiments, different vessels were heated using the Atlas hotplate, with and without the Atlas Stacking Drybath. In every case, an external thermocouple probe has been used with the system to accurately measure “reaction” temperature.
SELECTBIO

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