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Webcasts
Innovative Benign-by-design Flow Chemistry Protocols: From Nanomaterials Synthesis to Biomass/Waste Valorization
On demand webinar from Professor Rafael Luque, Universidad de Cordoba.
Managing Pharmaceutical Lab Data Management to Ensure Compliance
Join Stacey Brown and William Leonard, Senior Validation Analysts for Informatics at Thermo Fisher Scientific, to understand more about the complex requirements of pharmaceutical data management.

Market Reports
Emerging Pharmaceutical Markets 2012
Select Biosciences Ltd

The report covers all the key aspects of the various emerging pharmaceutical markets and has broadly outlined the factors that are affecting the industry. The report also provides current and predicted future performance of the pharmaceutical market in different regions of the world.
The Future of GPCRs in Drug Discovery
Business Insights

This report analyzes which classes of GPCR and specific GPCRs have been exploited. It looks at novel approaches to targeting GPCRs and their benefits and explores potential targets that could be of relevance to major, under-treated diseases. The report profiles small companies specializing in specific aspects of GPCR technology and analyzes the commercial outlook drugs targeting GPCRs.
Scientific News
Accessing Metabolic Information with Mass Spec
Scientists at the Helmholtz Zentrum München have developed a new mass spectrometry imaging method which, for the first time, makes it possible to analyze hundreds of metabolites in fixed tissue samples.
Simplifying Gene Testing Access for Ovarian Cancer Patients
Simplifying access to gene testing for women with ovarian cancer improves treatment choices and could save lives.
New Protein Model Could Accelerate Drug Development
Stony Brook-led international research team creates ultra-fast approach to model protein interactions.
New Method Opens Door to Development of Many New Medicines
Findings from TSRI reveal human proteins are better drug targets than previously thought.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Angina Drug Could Inform A New Strategy To Fight Cryptococcosis
A drug, more commonly used in the treatment of angina, could be the focus of a new strategy in fighting the fatal fungal infection cryptococcosis.
New Skin Cancer Drugs with Surprising Powers
Inserm team synthesizes and developed new drugs for melanoma.
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
A New Platform for Discovering Antibiotics
Harvard chemists hope to shorten time, difficulty in measuring their effectiveness, potential.
Business News
Pfizer's $40M Bid for BIND Therapeutics
BIND Therapeutics announced Pfizer's $40 million winning bid at a Section 363 asset auction.
Relypsa Acquired for $1.53Bn
Galenica is to acquire Relypsa, following company agreements, to reinforce its Vifor Pharma business unit.
RedHill, NIH Announce Collaboration
Collaboration aims to evaluate RedHill’s proprietary experimental therapy for the treatment of Ebola virus disease.
$736M Deal: Sagent Pharmaceuticals Acquisition by Nichi-Iko
Nichi-Iko in two step merger agreement with Sagent Pharmaceuticals at $21.75 per share.
Cormorant Pharmaceuticals Acquired by BMS for $520M
Cormorant Pharmaceuticals, developer of cancer and disease therapies, has been acquired by Bristol-Myers Squibb in a move to expand BMS pipelines.
Carbylan, KalVista Enter into Share Purchase Agreement
KalVista to become a wholly owned subsidiary of Carbylan, and KalVista shareholders to become majority owners of Carbylan upon the closing of the transaction.
Biotage Achieves ISO 14001:2004 Certification
This certificate is an international standard for an environmental management system (EMS) that helps businesses such as Biotage control and improve practices that are potentially harmful to the environment.
GSK Publishes Promising New Data for COPD Drug
Pioneering GSK study provides important new data on the effectiveness of Relvar Ellipta (FF/VI) when used in everyday clinical practice.
Arbor Pharma to Acquire XenoPort
Acquisition expands neurology product portfolio.
Evotec Extends Integrated Drug Discovery Alliance With Genentech
Evotec and Genentech will continue their drug discovery alliance for a further three years.

Events
GMP Summit 2016
15 Aug 2016
GMP Summit 2016 ...
EFMC-YMCS 2016 - 3rd EFMC Youn
01 Sep 2016
EFMC-YMCS 2016 - 3rd EFMC Youn ...
EMBO Conference: Chemical Biol
31 Aug 2016
EMBO Conference: Chemical Biol ...
21st EuroQSAR - 21st European
04 Sep 2016
21st EuroQSAR - 21st European ...

ePosters
Multiplexed Cell- and Bead-based Assays in a No-wash Format for Biologics Screening and Characterization
TTP Labtech Inc, One Kendall Square, Suite B2303, Cambridge MA 02139-1594, USA

Here we present the results generated from multiplexed no-wash protocols using TTP Labtech’s mirrorball, a laser scanning cytometer.
Development of a Homogenous RSV Neutralization Assay on the Mirrorball Fluorescence Cytometer: A Simple, Safe and Robust Approach for High-throughput Screening
TTP Labtech Ltd, Melbourn Science Park, Melbourn, Royston, Hertfordshire, SG86EE, UK.

Here we present the development and implementation of a simple RSV-neutralization assay on TTP Labtech’s mirrorball fluorescence cytometer.
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
1Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Toronto, ON. M5C 1B5. Canada; 2ACD/Labs, Moscow, Russia

A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
A Novel Set of Serum-Free, Xeno-Free Differentiation Media for Adipogenesis, Osteogenesis and Chondrogenesis of Human Mesenchymal Stem Cells from Various Tissue Sources
Biological Industries

An overview of a novel SF, XF differentiation system which enables achieving defined conditions for rapid generation of differentiated hMSCs towards tissue engineering and drug screening applications.
Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
1Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, U.K. 2

A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
Accurate Mass Spectral Database: Harnessing the Power of High Performance Mass Spectrometry at Long Last
LECO Corporation, Moscow State University

Standard mixtures comprising of alkanes, PAHs, semivolatiles, and pesticides were analyzed using a high resolution time-of-flight (HRTOF) mass spectrometer—Pegasus GC-HRT (LECO Corporation, Saint Joseph,MI)—at 10 spectra-per-second (m/z40–300) in high resolution mode (25,000 at FWHH). The resulting chromatographic peaks were automatically found, deconvoluted, and curated into an Accurate Mass Library (AML).
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , Gründenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zw

In this poster the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood samples.
Development and Application of Quantitative Immunoassays for Major Milk Allergens Bos d 5 (β-lactoglobulin) and Bos d 11 (β-casein)
1. Indoor Biotechnologies, Ltd., Cardiff, Wales, UK. 2. INRA, Gif-sur-Yvette, France

In this study, we sought to develop accurate, sensitive and reliable assays that would enable quantification of multiple milk allergens.

Diagnosing Coral disease with Metabolomic Markers
NYUAD

Application of untargeted metabolomics for the identification of disease markers in corals
Application Notes
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Multiplex Genotyping of Human Reference DNA Samples with Pharmacologically Important Single Nucleotide Polymorphisms using the IntelliQube® from Douglas Scientific
Douglas Scientific

This study demonstrates the ability of the IntelliQube along with Array Tape®, to successfully achieve two multiplexed SNP genotyping results in a single well and decrease thermal cycling times without compromising data quality. The combination of achieving two results per reaction well and shortened cycling times dramatically increases overall throughput.
The Application of MicroCal VP Capillary DSC at a Contract Development Organization
Malvern Instruments Limited

In this application note we describe a systematic approach to preformulation development that leverages biophysical characterization and standard analytics in the context of statistical design with the goal of shortening the pharmaceutical development cycle while improving the quality of the development studies.
Measuring The Particle Size Of Small Sample Volumes Using Laser Diffraction
Malvern Instruments Limited


Detecting the Presence of Anomolous Large Particles Within Powders Using Laser Diffraction Particle Size Analysis
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.
Measuring Small Quantities of Dry Powder Using the Aero S and Mastersizer 3000
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials with good reproducibility and illustrating the dispersion abilities of the Aero S.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
SELECTBIO

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